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Diagnostics
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Melanoma and Skin Cancer
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Melanoma and Skin Cancer

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 12822

Special Issue Editor

Dr. Chyi-Chia Richard Lee

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Guest Editor
Laboratory of Pathology, National Cancer Institute, Building 10, Room 2S235J, 10 Center Drive, Bethesda, MD 20892, USA
Interests: melanoma; skin cancers; dermatopathology; skin pathology; melanocytic skin lesions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Melanoma and skin cancer remain prevalent diseases worldwide, with high mortality rates for metastatic melanoma. Recent advances in early diagnosis and improvements in cancer management have led to early detection and increased survival of patients.

This Special Issue aims to include original reports and review articles on topics such as the cellular and molecular bases underlying melanoma and skin cancer development and progression, diagnosis and early detection, molecular testing and genomic approaches, biomarkers of cancer immunotherapy, and targeted therapy.

Dr. Chyi-Chia Richard Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Published Papers (2 papers)

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Review

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25 pages, 4852 KiB  
Review
Epithelioid Cutaneous Mesenchymal Neoplasms: A Practical Diagnostic Approach
by Joon Hyuk Choi and Jae Y. Ro
Diagnostics 2020, 10(4), 233; https://doi.org/10.3390/diagnostics10040233 - 17 Apr 2020
Cited by 4 | Viewed by 9134
Abstract
Epithelioid cells are rounded or polygonal cells with abundant eosinophilic or clear cytoplasm and ovoid to round nuclei, superficially resembling epithelial cells. Cutaneous mesenchymal neoplasms composed predominantly or exclusively of epithelioid cells are relatively uncommon and can cause considerable diagnostic difficulties due to [...] Read more.
Epithelioid cells are rounded or polygonal cells with abundant eosinophilic or clear cytoplasm and ovoid to round nuclei, superficially resembling epithelial cells. Cutaneous mesenchymal neoplasms composed predominantly or exclusively of epithelioid cells are relatively uncommon and can cause considerable diagnostic difficulties due to overlapping histologic features among heterogeneous groups of tumors. Familiarity with practical diagnostic approaches and recognition of key histopathologic features are important for correct diagnosis and management. This review summarizes the histologic features of epithelioid cutaneous mesenchymal neoplasms and discusses their differential diagnoses from malignant melanomas and carcinomas. Full article
(This article belongs to the Special Issue Melanoma and Skin Cancer)
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Other

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6 pages, 9538 KiB  
Case Report
Safety and Efficacy of Salvage Neck Dissection Following Carbon-ion Radiotherapy with Chemotherapy for a Patient with Mucosal Malignant Melanoma of Head and Neck
by Hidenori Suzuki, Eiichi Sasaki, Risa Motai, Seiya Goto, Daisuke Nishikawa, Shintaro Beppu, Hoshino Terada, Michi Sawabe and Nobuhiro Hanai
Diagnostics 2020, 10(2), 82; https://doi.org/10.3390/diagnostics10020082 - 3 Feb 2020
Cited by 3 | Viewed by 3063
Abstract
Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon–ion radiotherapy with concurrent chemotherapy are not well described, and carbon–ion radiation protocols have not been fully developed. A 77 year old [...] Read more.
Mucosal malignant melanoma of the head and neck is a rare diagnosis. The safety and efficacy of salvage neck dissection following carbon–ion radiotherapy with concurrent chemotherapy are not well described, and carbon–ion radiation protocols have not been fully developed. A 77 year old woman with crT0N1M0 mucosal melanoma of the head and neck achieved a complete response following initial treatment with carbon–ion radiotherapy and concurrent chemotherapy. She was treated with salvage neck dissection for as a cervical lymph node metastasis 16 months after initial treatment. She experienced neither Clavien-Dindo Grade 3 or 4 postoperative complications nor subsequent recurrence of disease at 3 months following salvage neck dissection. Surgical specimens may be useful for future precision oncology based on the molecular biology of recurrence melanoma with poor prognosis. Full article
(This article belongs to the Special Issue Melanoma and Skin Cancer)
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