Advances in Pathogenesis, Molecular Mechanisms, and Therapeutic Strategies for Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 February 2025 | Viewed by 297
Special Issue Editor
Interests: stem cells; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis (ALS), pose a significant and escalating public health challenge globally. The complexity of these conditions necessitates a thorough understanding of their pathogenesis and molecular mechanisms to develop effective therapeutic strategies. Recent advancements in biomedical research have significantly deepened our understandings of the pathogenesis of these diseases, revealing intricate molecular pathways and identifying novel therapeutic targets.
This Special Issue seeks to highlight cutting-edge research and comprehensive reviews that explore the latest developments in the pathogenesis, molecular mechanisms, and therapeutic strategies of neurodegenerative diseases. We invite submissions that delve into the multifaceted interplay of genetic, environmental, and lifestyle factors that contribute to these disorders. Key areas of interest include the roles of protein misfolding and aggregation, mitochondrial dysfunction, oxidative stress, neuroinflammation, and impaired protein quality control systems in disease progression.
In addition to studies elucidating disease mechanisms, we encourage submissions focusing on innovative therapeutic approaches. This includes gene therapy, RNA-based therapies, small molecule inhibitors, and immunotherapies targeting pathogenic proteins such as amyloid β, tau, and α-synuclein. We are particularly interested in research exploring the potential of stem cell-based regenerative therapies and neuroprotective strategies aimed at mitigating oxidative stress and mitochondrial dysfunction.
By bringing together diverse perspectives and cutting-edge research, this Special Issue aims to foster a deeper understanding of neurodegenerative diseases and pave the way for more effective, personalized therapeutic interventions. We look forward to your contributions that will advance the field and improve patient outcomes and quality of life.
Dr. Abdullah Sheikh
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegeneration
- molecular pathways
- protein aggregation
- gene therapy
- neuroprotection
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