Salmonella Pathophysiology and Host-Bacteria Relationship

Dear Colleagues,

Salmonella is a group of Gram-negative bacteria that account for varied pathogy in the host depending on the serovars. Typhoidal and non-typhoidal Salmonella (NTS) interact with the host defense machinery and elicit  varied immune responses in humans. NTS serovars cause a local intestinal immune response in the gut mucosa resulting in self-limiting diarrhea. Bacteremia is rare in NTS infection but can occur in immunocompromised individuals and infants in sub-saharan regions. On the other hand, Typhoidal serovars do not cause acute diarrhea or induce neutrophil migration into the gut lumen. After circumventing the acidic environment in the stomach, the bacteria prevents neutrophil infiltration resulting from activation of TLRs, and enters the circulation via immune cells to establish systemic infection. Host-pathogen interaction in salmonellosis using patient records, murine models, and whole genome sequencing have provided new insights. The genome of Typhoidal servovars harbor many inactivated or disrupted genes compared to the NTS serovas. This may partly contribute to serovar-specific disease outcome in the host. A better understanding of the Salmonella pathogenesis will help develop potential therapeutic strategies.

This Special Issue invites original research articles, communications, and reviews that describe the Salmonella pathophysiology, its virulence machinery and ability to interact and circumvent host immune response machinery to establish sucessful infection. We look forward to receiving your contributions.

Prof. Dr. John Hwa Lee
Guest Editor

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