Amniotic Fluid and Placental Membranes as Sources of Stem Cells 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 17101
Special Issue Editors
Interests: stem cells and age-related disorders
Special Issues, Collections and Topics in MDPI journals
Interests: regenerative medicine; tissue engineering; amniotic-derived stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Significant recent advances in regenerative therapy have intensified research on different sources of stem cells.
Although embryonic and adult tissues can be used for the isolation of pluripotent stem cells, significant limitations, including ethical concerns, complexity of isolation/culture, and tumorigenicity, have hindered translation of laboratory findings into clinical practice.
Stem cell research has drawn attention toward amniotic membrane and amniotic fluid stem cells, since these sources possess many advantages: first of all, cells can be extracted from discarded fetal material; secondly, abundant stem cells can be obtained; and finally, these stem cell sources are free from ethical considerations and tumorigenicity. Stem cells derived from amniotic fluid and membranes possess embryonic stem cell-like differentiation capability and, similar to mesenchymal stem cells, are also able to modulate the local immune response. Their reduced immunogenicity and immunomodulatory properties allow their use in allo- and xeno-transplantation settings. These, and other properties, make these cells attractive for cellular therapy.
This Special Issue on “Amniotic Fluid and Placental Membranes as Sources of Stem Cells: Progress and Challenges” welcomes original research articles that illustrate and stimulate the growing efforts to understand the implication of stem cells in pathological conditions such as cardiovascular and metabolic diseases, inflammatory, autoimmune, skeletal, and degenerative diseases.
Dr. Tullia Maraldi
Guest Editors
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Keywords
- amniotic fluid stem cells
- amniotic epithelial stem cells
- placental stem cells
- regenerative therapy
- immunomodulation
- secretome
- exosomes
- degenerative diseases
- inflammatory diseases
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