Novel Biomarkers and Promising Therapeutical Approaches in Risk Prediction of Cardiovascular Disease: The Prognostic Significance of Endothelial Dysfunction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 25540
Special Issue Editor
Interests: endothelial dysfunction, endothelial cells, animal models and animal welfare, vascular failure, oxidative stress, metainflammation, insulin resistance, metabolic syndrome, diabesity, pharmacology.
Special Issue Information
Dear Colleagues,
Cardiovascular diseases are still among the major causes of morbidity and mortality worldwide. Lifestyle risk factors such as smoking, diet, obesity and physical inactivity contribute to increase the incidence of cardiovascular events by promoting a proinflammatory condition that affects proliferation, migration and increased permeability of endothelial cells. In turn, the endothelial inflammatory phenotype triggers the synthesis and release of cytokines, chemokines and growth factors that further exacerbate endothelial health and impair vascular performance.
Endothelial dysfunction underlies the onset and progression of cardiovascular diseases, is closely correlated with the pathophysiology of metabolic disturbances, and lies beneath senescence and aging. While extensive studies and consistent results suggest that changes in endothelial cell function precede, accompany and may potentially predict changes in cardiac development and function, the search for biological markers and instrumental approaches able to evaluate endothelial function is still a great challenge.
Filling the gap between mechanisms of immediate or delayed endothelium responses under specific conditions and associated markers and modulators would reveal interrelations, feedback, and feed-forward regulatory effects, with the ultimate goal to improve our understanding on the pathogenesis of several diseases and help to delineate the most effective strategies and therapeutical approaches.
This Special Issue is dedicated to all original research articles and state-of-the- art reviews, exploring molecular mechanisms underlying a correlation between endothelial dysfunction and cardiovascular complications, as well as investigations testing novel biomarkers and therapeutic targets that can be used for the diagnosis and prognosis of disease helping to broaden our understanding and improving patients treatments.
Dr. Maria Assunta Potenza
Guest Editor
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Keywords
- endothelial dysfunction
- endothelial mediators
- oxidative stress
- signalling pathways
- adipokines
- circulating and molecular biomarkers
- cardiovascular diseases
- metabolic disorders
- epigenetic
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