Gut Dysbiosis: Molecular Mechanisms and Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 24660
Special Issue Editors
Interests: inflammatory bowel disease; intestinal inflammation; colorectal cancer; intestinal epithelial barrier; microbiota
Special Issues, Collections and Topics in MDPI journals
Interests: colorectal cancer; immunotherapy; inflammatory bowel diseases; anti-cancer drugs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Several studies have shown that gut dysbiosis—characterized by a reduction in microbial diversity, decreased frequency of beneficial bacterial strains and overgrowth of pathobionts—frequently associates with the development of intestinal and extra-intestinal disorders (e.g., neurological disorders). Many environmental factors (including diet, drugs and stress) can trigger gut dysbiosis by altering the complex interaction between microbial ecology and the host immune system, thereby promoting intestinal epithelial barrier dysfunctions that may ultimately lead to the development of several pathological conditions. Targeting gut dysbiosis, in combination with standard therapies, is now considered a valuable and promising strategy to prevent and/or treat gut-related diseases, and a better understanding of the molecular and cellular pathways underlying this condition is definitely required.
In this Special Issue, we invite researchers working on gut dysbiosis to submit original articles or reviews to improve our knowledge on this complex and fascinating field.
Potential topics include, but are not limited to, the following:
- Role of dysbiotic microbiota and microbial metabolites in gut homeostasis, intestinal barrier function and host immune system;
- Contribution of gut dysbiosis to the development of intestinal (e.g., inflammatory bowel diseases, colorectal cancer) and extra-intestinal disorders (e.g., neurological disorders, diabetes);
- Therapeutic strategies for gut microbiota modulation in pathological conditions (e.g., probiotic treatment, fecal microbiota transplantation).
You may choose our Joint Special Issue in Biomedicines.
Dr. Federica Laudisi
Dr. Carmine Stolfi
Guest Editors
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