Epilepsy Research and Antiepileptic Drugs
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (18 August 2023) | Viewed by 26913
Special Issue Editor
Special Issue Information
Dear Colleagues,
Epilepsy is a group of non-communicable neurological disorders characterized by recurrent epileptic seizures. Animal models are mainly used to study the mechanisms of epilepsy, brain electrophysiology, and behavioral changes and to screen new antiepileptic drugs. Epilepsy is accompanied by active free radical reactions, so scavenging free radicals and blocking free radical reactions open up a new way for the treatment of epilepsy. Recent antioxidant agents are studied to develop new types of antiepileptic drugs that protect against neuronal damage originating from seizure onset.
In addition, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors mediate fast excitatory synaptic transmission in epilepsy-related brain regions and play a role in the occurrence of epilepsy and epilepsy-induced brain damage.
This Special Issue, titled “Epilepsy Research and Antiepileptic Drug Development”, will focus on fundamental research of epilepsy animal models and antiepileptic drug development research. Experimental papers sharing new data and up-to-date review articles are welcome.
Prof. Dr. Yuto Ueda
Guest Editor
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Keywords
- epilepsy
- glutamate
- free radical
- reactive oxygen species
- antioxidant
- antiepileptic drug
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