Advanced Science in Alzheimer’s Disease

Dear Colleagues,

Contemporary research into Alzheimer’s disease (AD) increasingly focuses on elucidating its molecular intricacies. At the molecular level, AD is distinguished by the aggregation of amyloid-beta peptides and hyperphosphorylated tau proteins, resulting in the formation of insoluble plaques and neurofibrillary tangles, respectively. This pathological hallmark disrupts neuronal function, synaptic transmission, and, ultimately, cognitive abilities. Molecular investigations aim to elucidate the precise mechanisms governing the synthesis, clearance, and cytotoxicity of these proteins, as well as their interactions with cellular processes such as inflammation, oxidative stress, and mitochondrial dysfunction. Moreover, genetic studies have pinpointed risk variants associated with AD, shedding light on molecular pathways implicated in disease pathogenesis. Leveraging advanced molecular techniques, including genome editing, proteomics, and high-resolution imaging, researchers strive to decipher the molecular underpinnings of AD progression. Insights derived from these efforts hold promise for the development of targeted therapies aimed at arresting or reversing molecular aberrations, thus offering prospects for efficacious interventions in the battle against AD.

Dr. Silvia Boschi
Guest Editor

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• neuroinflammation
• synaptic dysfunction
• oxidative stress
• neurofibrillary tangles
• mitochondrial dysfunction
• biomarkers