Thyroid Hormone Derivatives and Thyroid Hormone Receptors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 6806
Special Issue Editors
Interests: metabolic biochemistry; thyroid hormone analogs and metabolites; vitamin D analogs; drug design, synthesis and development
Special Issues, Collections and Topics in MDPI journals
Interests: hypoparathyroidism; hyperparathyroidism; parathyroid tumors; thyroid hormone analogs and metabolites; vitamin D metabolism; serum vitamin D levels and heart failure; endocrinology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Thyroid hormone receptors (TRs) are potent regulators of the proliferation and differentiation of many cell types. This can explain the important role of the thyroid hormones (THs) and their receptors in key processes, such as growth, development, tissue homeostasis or cancer. Most THs effects are mediated by two different TR isoforms, namely TRα and TRβ, with the TRβ isoform known to be responsible for the main beneficial effects of TH on the liver. In the brain, despite the crucial role of TRα isoforms in neuronal development, TRβ was proposed to play a role in remyelination processes. Consequently, over the past two decades, considerable efforts have been made to develop TH analogues capable of differentiating between beneficial actions on the liver and central nervous system (CNS) and deleterious effects on the heart, muscle and bone. In addition to the classical genomic actions of THs, a relevant number of reports suggested that THs might act through alternative pathways that do not require direct interactions between TRs and DNA. Moreover, several TH metabolites, including 3,5-T2 or 3-T1AM, were associated with a broad range of actions, mostly attributable to short-term effects.
The aim of this Special Issue is to deepen our understanding of TH actions and the potential therapeutic applications of TH analogues.
Dr. Grazia Chiellini
Dr. Federica Saponaro
Guest Editors
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Keywords
- thyroid hormone receptors
- central nervous system diseases
- neurodegenerative diseases
- neurodegeneration
- neuroinflammation
- liver diseases
- dyslipidemia
- hyperlipidemia
- obesity
- T2DM (type 2 diabetes mellitus)
- atherosclerosis
- cancer
- reduced sensitivity to TH
- TH metabolites
- TH mimetics
- hypothyroidism
- hyperthyroidism
- deiodinases
- regenerative medicine
- biomarkers
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