Molecular Mechanism of pH Regulation: From Physiology to Pathology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 22095
Special Issue Editor
Interests: pH regulation; acid/base disturbance; metabolic acidosis; sodium-bicarbonate transporter; brain acidosis; acidosis in cancer; structure-function of acid/base transporter
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pH in extracellular fluid is normally maintained at 7.4, equivalent to one H+ ion per 25 million water molecules. Despite such extremely low levels, H+ has profound effects on function, as it binds to proteins and alters their structure and properties. A variety of proteins, including receptors, signal transduction molecules, enzymes, and structural proteins, can be altered in their function by H+, thereby interfering with their cellular and systemic roles. Maintaining normal pH is frequently challenged by both physiological and pathological conditions. For example, acidification occurs as metabolic activity increases (such as during heavy exercise) or when blood supply is inefficient in disease states (such as ischemia and cancer). Numerous proteins are inhibited by high H+ levels, and thus, acidification inhibits cellular activity. Severe acidification is deleterious to normal cells, causing cell death. However, acidification can be adversely beneficial under some pathological conditions. Cancer cells thrive in an acidic environment and undergo adaptations to promote survival and proliferation, such that acidic pH stimulates cancer cell growth, migration, and invasion. The effects of pH abnormalities on physiological functions and relevant diseases have been extensively studied for the past decades. Despite considerable progress, though, the fundamental question of how pH is regulated at the molecular level is unclear. The current Special Issue focuses on progress toward understanding the molecular mechanism of pH regulation under physiological conditions and its involvement in pathogenesis. The topic is open to original studies, reviews, and new methodologies, ranging from molecular and cellular level to integrated organ systems.
Dr. Inyeong Choi
Guest Editor
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Keywords
- pH regulation
- acid base transporter
- acid base disturbance
- acidosis
- intracellular pH
- NBC
- NHE
- cancer
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