Sarcomeric Proteins in Health and Disease 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 19318
Special Issue Editor
Interests: biophysics of muscle contraction; non-crystalline X-ray diffraction; synchrotron radiation instrumentation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
This Special Issue is the continuation of our previous Special Issue “Sarcomeric Proteins in Health and Disease”.
Many inherited diseases in skeletal and cardiac muscle have their origin in mutations in sarcomeric proteins. Developing rationale therapeutic strategies will require a detailed understanding of the normal structure and function of the proteins that comprise the sarcomere, as well as how these structures and functions are altered in disease.
The aim of the present Special Issue is to bring together reviews and original papers on the structure and function of specific components of the sarcomere as they relate to overall contractile function and its regulation in normal and diseased muscle tissue. Historically, the focus in molecular biophysical studies of muscle contraction has been on actin–myosin interaction.
This issue is intended to be an opportunity to explore other aspects of sarcomere structure and function. These could include topics such as:(1) the elastic properties of sarcomeric proteins and their role in regulation, (2) structural dynamics of the Z-lines and M-lines, (3) sarcomeric structural proteins and cell signaling pathways, and (4) regulation of turnover of sarcomeric proteins. This list is not intended to be exclusive. Any of these topics could include investigation and discussion of mutations and post-translational modification alter protein structure and either normal or pathological function.
Prof. Dr. Thomas C. Irving
Guest Editor
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