Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation 2019
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 47444
Special Issue Editors
Interests: cancer; PRDM genes; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
2. Department of Science and Technology, University of Naples “Parthenope", Centro Direzionale, Isola C4-800143, Naples, Italy
Interests: human genetic diseases; molecular mechanism pathogenesis; whole-transcriptome analysis; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals
Interests: PRDM genes; cancer; transcriptional regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is the continuation of our previous special issue "Transcriptional Regulation: Molecules, Involved Mechanisms and Misregulation".Transcriptional regulation of gene expression in response to intra- and extra-cellular changes includes a series of biophysical processes controlled by innumerable transcription factors, cofactors and chromatin regulators. This control involves multiple temporal and functional steps and levels ranging from specific DNA–protein interactions to the recruitment and assembly of nucleoprotein complexes. The huge amount of participating molecules, together with the complexity of the mechanism, constrains the use of novel strategies to fully understand how DNA sequence information, epigenetic modifications and transcription machinery cooperate to regulate gene expression. Recent advances in “omics” and computational biology have provided promising tools to reliably integrate different layers of information from biophysical, biochemical and molecular cell biology studies. Thus, this Special Issue is focused on the molecular mechanisms leading to specific gene expression patterns, with particular attention to molecules and complexes involved in transcription regulation. Especially, studies employing these novel integrated approaches will be considered as priority. Additionally, research papers and review articles exploring the effects of transcriptional misregulation on human diseases will be also included.
Dr. Amelia Casamassimi
Prof. Dr. Alfredo Ciccodicola
Dr. Monica Rienzo
Guest Editors
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Keywords
- transcription machinery
- nucleic acid-protein interactions
- chromatin modifying complexes
- molecular recognition
- biomolecular interactions
- posttranscriptional modifications
- transcription misregulation
- computational biophysics
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