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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Coronavirus Disease (COVID-19): Pathophysiology 5.0

edited by

Malgorzata Kloc

and

Jacek Z. Kubiak

submission deadline 20 Dec 2024 | 9 articles | Viewed by 39851 | Submission Open

Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Natural Bioactive Compounds: 3rd Edition

edited by

Letteria Minutoli

and

Giovanni Pallio

submission deadline 20 Dec 2024 | 18 articles | Viewed by 32102 | Submission Open

Keywords: inflammation; cytokines; ROS; oxidative stress; natural products; flavonoids; cannabinoids

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research of Nanomaterials in Molecular Science

edited by

Giovanna Iezzi

submission deadline 20 Dec 2024 | 18 articles | Viewed by 25729 | Submission Open

Keywords: nanomaterials; medical research; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Physiological and Pathological Progression of Neurological Diseases

edited by

Daniele Bottai

submission deadline 20 Dec 2024 | 13 articles | Viewed by 21484 | Submission Open

Keywords: neurological diseases; molecular pathways; spinal cord lesion; cognitive disabilities; epilepsy; stroke; motorneuron diseases; glioblastoma; autism; stem cells; organoids

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Resistance in Cancer: Molecular Mechanisms and Tackling Strategies, 2nd Edition

edited by

Kathleen Pishas

submission deadline 20 Dec 2024 | 9 articles | Viewed by 21174 | Submission Open

Keywords: apoptosis; cancer; clinical trials; chemotherapy; drug metabolism; drug resistance; drug delivery; heterogeneity; immunotherapy; microenvironment

(This special issue belongs to the Section Molecular Pharmacology)

Trends and Prospects of Flow Cytometry in Cell and Molecular Biology

edited by

Claudio Ortolani

José-Enrique O’Connor

and

Monia Lenzi

submission deadline 20 Dec 2024 | 11 articles | Viewed by 21121 | Submission Open

Keywords: biochemistry; molecular biology; cell function; cell metabolism; new cytometries; new applications; new methods; microbiology

(This special issue belongs to the Section Molecular Biology)

New Players in the Research of Oxidative Stress and Cancer

edited by

Ana Čipak Gašparović

submission deadline 20 Dec 2024 | 7 articles | Viewed by 19208 | Submission Open

Keywords: cancer; oxidative stress; biomarkes; redox signaling pathway; therapy resistance

(This special issue belongs to the Section Biochemistry)

Therapeutic Potential of Antioxidants in the Prevention of Human Diseases

edited by

Kota V. Ramana

submission deadline 20 Dec 2024 | 8 articles | Viewed by 18792 | Submission Open

Keywords: antioxidants; vitamins; inflammation; cancer; neurological complications; diabetes; flavonoids; natural compounds; cancer; infections; COVID-19

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Pathogenesis and Treatment of Skin Cancer

edited by

Enrica Flori

Vittoria Maresca

and

Giorgia Cardinali

submission deadline 20 Dec 2024 | 10 articles | Viewed by 17292 | Submission Open

Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways

(This special issue belongs to the Section Molecular Oncology)

Latest Review Papers in Molecular Immunology 2024

edited by

Manlio Ferrarini

and

Vincenzo Barnaba

submission deadline 20 Dec 2024 | 10 articles | Viewed by 17260 | Submission Open

Keywords: molecular immunology; review; immune cells

(This special issue belongs to the Section Molecular Immunology)

Plant Responses to Heat Stress

edited by

Biao Jin

and

Nianjun Teng

submission deadline 20 Dec 2024 | 7 articles | Viewed by 17195 | Submission Open

Keywords: high temperatures; thermotolerance; stress memory; temperature sensing; signal transduction; protein homeostasis; genomics; transcriptomics; proteomics; metabolomics; epigenetics; microrna; omics; warming; heat-stress priming; heat memory; alternative splicing; heat adaptation; heat tolerance; oxidative stress; photosynthesis; reactive oxygen species; signaling molecules; heat shock

(This special issue belongs to the Section Molecular Plant Sciences)

G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities

edited by J. Adolfo García-Sáinz

submission deadline 20 Dec 2024 | 10 articles | Viewed by 17036 | Submission Open

Keywords: GPCR; cell signaling; small molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode

(This special issue belongs to the Section Molecular Pharmacology)

Development of Dopaminergic Neurons 3.0

edited by

Yasemin M. Akay

submission deadline 20 Dec 2024 | 8 articles | Viewed by 16989 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

The Promising Future of CAR-Based Therapies: A Matter of Molecular Details

edited by

Massimiliano Mazza

and

Sarah Tettamanti

submission deadline 20 Dec 2024 | 6 articles | Viewed by 16794 | Submission Open

Keywords: CAR; genetic engineering; T; NK; CIK; ATMP; GMP manufacturing; off-the-shelf; TME; cell exhaustion

(This special issue belongs to the Section Molecular Immunology)

Biophysical Characterization and Molecular Engineering of Multidomain Proteins 3.0

edited by

Koichi Kato

and

Takayuki Uchihashi

submission deadline 20 Dec 2024 | 8 articles | Viewed by 16463 | Submission Open

(This special issue belongs to the Section Molecular Biophysics)

The Role of Estrogen and Its Receptors in the Development and Therapy of Cancer

edited by

Margalida Torrens-Mas

and

Mercedes Nadal-Serrano

submission deadline 20 Dec 2024 | 7 articles | Viewed by 16240 | Submission Open

Keywords: estrogen; estrogen receptor; breast cancer; anticancer therapy; cancer development; cancer progression; metastasis

(This special issue belongs to the Section Molecular Oncology)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Dec 2024 | 6 articles | Viewed by 15822 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Cellular Crosstalk in the Tumor Microenvironment

edited by

Ehnman Monika

Rainer Heuchel

and

Jonas Fuxe

submission deadline 20 Dec 2024 | 7 articles | Viewed by 15530 | Submission Open

Keywords: cancer; metastasis; inflammation; cancer-associated fibroblasts; biomarkers; multiplex imaging; in vitro models; animal models; immunotherapy

(This special issue belongs to the Section Biochemistry)

From Nanotechnology to Nanomedicine: Past, Present and Future

edited by

Morozova Olga

submission deadline 20 Dec 2024 | 4 articles | Viewed by 15506 | Submission Open

Keywords: natural and synthetic polymers; composite materials; biomimetics; bionanotechnology; side products of biodegradation

(This special issue belongs to the Section Molecular Nanoscience)

Peptides as Biochemical Tools and Modulators of Biological Activity

edited by

Annamaria Aloisio

submission deadline 20 Dec 2024 | 4 articles | Viewed by 15488 | Submission Open

Keywords: peptides; phage display; stem cells; mesenchymal stromal cells; cancer; leukemia; tumor targeting; drug delivery

(This special issue belongs to the Section Molecular Biology)

Natural Compounds and Oxidative Stress

edited by

Valeria Sorrenti

submission deadline 20 Dec 2024 | 6 articles | Viewed by 14852 | Submission Open

Keywords: oxidative stress; natural compounds; bioactive compounds; chronic diseases; therapeutic agents

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Current Research for Ovarian Cancer Biology and Therapeutics

edited by

Carmela Ricciardelli

submission deadline 20 Dec 2024 | 7 articles | Viewed by 14848 | Submission Open

Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapetic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models

(This special issue belongs to the Section Molecular Oncology)

Acid–Base Metabolism, and Human Physiology and Pathophysiology

edited by

Lynda A. Frassetto

and

Thomas Remer

submission deadline 20 Dec 2024 | 6 articles | Viewed by 14490 | Submission Open

Keywords: ammoniagenesis; FGF-23-Klotho axis; growth hormone– IGF axis; hormones; kidney physiology and function; NAE; nutrition; potassium balance; PRAL; renin– angiotensin aldosterone system

(This special issue belongs to the Section Molecular Biology)

New Advances in Type 2 Diabetes and Its Complications

edited by

Anca Pantea Stoian

submission deadline 20 Dec 2024 | 5 articles | Viewed by 14439 | Submission Open

Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Olive Oil and Derivatives for Human Health

edited by

Amal Kaddoumi

submission deadline 20 Dec 2024 | 5 articles | Viewed by 14350 | Submission Open

Keywords: extra-virgin olive oil; olive oil; oleic acid; EVOO phenolics; oleocanthal; olive leaf extract; human diseases; neurodegenerative diseases; cardiovascular disease; cancer; mechanism of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Regeneration for Spinal Diseases 4.0

edited by

Inbo Han

Takashi Yurube

and

Daisuke Sakai

submission deadline 20 Dec 2024 | 7 articles | Viewed by 14252 | Submission Open

Keywords: regeneration; intervertebral disc degeneration; spinal cord injury; osteoporosis; spinal fusion; muscle regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Omics

edited by

Nicole Hansmeier

submission deadline 20 Dec 2024 | 10 articles | Viewed by 14220 | Submission Open

Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics

(This special issue belongs to the Section Molecular Microbiology)

Cellular Responses to Environmental Changes

edited by

Marcus Krüger

submission deadline 20 Dec 2024 | 6 articles | Viewed by 14096 | Submission Open

Keywords: environment sensing; cellular stress response; (bio)chemical environment; (bio)physical environment; mechanical environment; thermal environment; radiation; enviromics; receptors; signal transduction pathways

(This special issue belongs to the Section Molecular Biology)

New Trends in Alzheimer’s Disease Research: From Molecular Mechanisms to Therapeutics: 2nd Edition

edited by

Ramón Cacabelos

submission deadline 20 Dec 2024 | 7 articles | Viewed by 13763 | Submission Open

Keywords: Alzheimer’ s disease; pathogenic mechanisms; genomics; epigenetics; biomarkers; prevention; treatment; pharmacogenetics

(This special issue belongs to the Section Molecular Neurobiology)

Polyphenols and Their Impact on Human Health: 2nd Edition

edited by

Lucia Panzella

submission deadline 20 Dec 2024 | 4 articles | Viewed by 13466 | Submission Open

Keywords: polyphenols; antioxidants; food supplements; biomedical devices; skincare; agri-food by-products; sustainability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Resveratrol: Improving Human Health and Preventing Diseases

edited by

José Díaz-Chávez

submission deadline 20 Dec 2024 | 5 articles | Viewed by 13382 | Submission Open

Keywords: resveratrol supplementation; resveratrol metabolites; sirtuins; aging; epigenetic; benefits in chronic disease; treatment

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism in Multiple Sclerosis and Related Disorders: 2nd Edition

edited by

Hans-Peter Hartung

Giancarlo Comi

and Kazuo Fujihara

submission deadline 20 Dec 2024 | 10 articles | Viewed by 13134 | Submission Open

Keywords: neurodegeneration; multiple sclerosis; NMOSD; MOGAD; disease modifying treatments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Characterization of Extracellular Vesicles in Disease

edited by

Verena Tretter

submission deadline 20 Dec 2024 | 6 articles | Viewed by 13108 | Submission Open

Keywords: extracellular vesicle; exosomes; microvesicles; vesicle cargo

(This special issue belongs to the Section Molecular Biology)

Molecular and Structural Research Advances in Model Plants

edited by

Ioannis-Dimosthenis Adamakis

submission deadline 20 Dec 2024 | 8 articles | Viewed by 12896 | Submission Open

Keywords: A. thaliana; plant biology; model organisms; plant models; non-model plant models

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights on the Health Benefits of Vitamins, Minerals and Probiotics

edited by

Francesca Uberti

and

Claudia Penna

submission deadline 20 Dec 2024 | 3 articles | Viewed by 12836 | Submission Open

Keywords: microbiome; epigenetic alterations; molecular pathways; biomedicines; system biology; human diseases; dietary supplementation; disease prevention and treatment; gut/other tissues axes; clinical trials

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Research on Plant Genomics and Genome Editing

edited by

Fabrizio Carbone

submission deadline 20 Dec 2024 | 8 articles | Viewed by 12816 | Submission Open

Keywords: next-generation sequencing; structural and functional genomics; SNPs; miRNA; LncRNA; CRISPR/Cas9; TALEN; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology of Human Fertility—2nd Edition

edited by

Antonio Simone Laganà

and

Simone Garzon

submission deadline 20 Dec 2024 | 5 articles | Viewed by 12668 | Submission Open

Keywords: infertility; gametes; embryo; implantation; placenta; endometrium; gynecological endocrinology; assisted reproduction technology; ovaries; inflammation; endometriosis

(This special issue belongs to the Section Molecular Biology)

The Role of Microbiota in Immunity and Inflammation

edited by

Veronica Marrella

Barbara Cassani

and

Francesca Pala

submission deadline 20 Dec 2024 | 4 articles | Viewed by 12410 | Submission Open

Keywords: microbiota; metabolites; antimicrobial peptides; innate/adaptive immunity; inflammatory diseases; infections; cytokines

(This special issue belongs to the Section Molecular Microbiology)

Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 3.0

edited by

Menotti Ruvo

and

Annamaria Sandomenico

submission deadline 20 Dec 2024 | 6 articles | Viewed by 12276 | Submission Open

Keywords: Mabs; Fabs; ScFv; nanobodies; biomarker detection; bispecific antibodies; analyte detection; sandwich assays

(This special issue belongs to the Section Macromolecules)

Inflammation and Cancer 2023

edited by

Takuji Tanaka

Masahito Shimizu

and

Michihiro Mutoh

submission deadline 20 Dec 2024 | 6 articles | Viewed by 11862 | Submission Open

Keywords: inflammation; cytokines; gut microbiota; insulin resistance; molecular biology; autophagy; epithelial-to-mesenchymal transition (EMT); tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

The Role of Microglia in Neurological Disorders

edited by

Masashi Tanaka

submission deadline 20 Dec 2024 | 6 articles | Viewed by 11710 | Submission Open

Keywords: Alzheimer’ s disease; inflammation; microglia; multiple sclerosis; neurodegenerative diseases; neurological disorders; neuron; Parkinson’ s disease; phagocytosis

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Lung Inflammation, Injury, and Repair

edited by

Andreas Schwingshackl

submission deadline 20 Dec 2024 | 7 articles | Viewed by 11463 | Submission Open

Keywords: lung; inflammation; injury; repair; fibrosis; diagnostics; therapeutics; acute respiratory distress syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers in Rare Diseases 3.0

edited by

Bridget E. Bax

submission deadline 20 Dec 2024 | 5 articles | Viewed by 11430 | Submission Open

Keywords: orphan diseases; rare diseases; inborn errors of metabolism; mitochondrial disorders; biomarker discovery; biomarker panels; multiomics; endpoint measures

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Defense against Abiotic Stress 2.0

edited by

Emilia Apostolova

submission deadline 20 Dec 2024 | 5 articles | Viewed by 11396 | Submission Open

Keywords: abiotic stress; antioxidant activity; chlorophyll fluorescence; environmental pollution; photosynthesis; photosynthetic machinery; plant responses; plant tolerance; reactive oxygen species; thylakoid membranes; photosynthetic machinery; signal molecules

(This special issue belongs to the Section Molecular Plant Sciences)

Kinase Inhibitors and Kinase-Targeted Cancer Therapies

edited by

Olivier E. Pardo

submission deadline 20 Dec 2024 | 4 articles | Viewed by 11253 | Submission Open

Keywords: kinase activity inhibitors; degraders; antibodies; nanobodies; protein– kinase interaction inhibitors

(This special issue belongs to the Section Biochemistry)

Therapeutic Potential of Natural Compounds: Insights into Mechanisms, Molecular Docking, and Biological Activities

edited by

Rafał Hałasa

submission deadline 20 Dec 2024 | 9 articles | Viewed by 11176 | Submission Open

Keywords: natural compounds; synthetic derivatives of natural compounds; biological activity; mechanism of action; molecular docking; therapeutic potential; anticancer; antimicrobial; antiviral; anti-civilization diseases; antiobesity; antidiabetes; preventing the development of cardiovascular diseases; including myocardial infarction; hypertension and ischemic heart disease; food hypersensitivity; antiallergy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Fractalkine (CX3CL1) and Its Chemoattractant and Adhesion Molecule Properties in Health and Disease

edited by

Dariusz Szukiewicz

submission deadline 20 Dec 2024 | 6 articles | Viewed by 11069 | Submission Open

Keywords: fractalkine; transmembrane fractalkine; soluble fractalkine; fractalkine receptor; CX3CL1-CX3CR1 signaling; inflammation; chemokine; cell adhesion; chemotaxis; immune response; angiogenesis; implantation; atherosclerosis; carcinogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Towards an Understanding of Retinal Diseases and Novel Treatment: 3rd Edition

edited by

Stephanie C. Joachim

submission deadline 20 Dec 2024 | 5 articles | Viewed by 11020 | Submission Open

Keywords: retina; glaucoma; age-related macular degeneration (AMD); animal model; cell culture; organ culture; molecular pathways; biomarker; neuroprotection

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Therapeutic Targets in the Evolving Landscape of Cancer Immunotherapy

edited by

Domenico Galati

submission deadline 20 Dec 2024 | 7 articles | Viewed by 10948 | Submission Open

Keywords: immune checkpoints; targeted therapies; tumor microenvironment; cancer immunology; precision medicine; cell-based cancer therapy

(This special issue belongs to the Section Molecular Immunology)

Research Progress on the Mechanism and Treatment of Cardiomyopathy

edited by

Michael T. Chin

submission deadline 20 Dec 2024 | 8 articles | Viewed by 10839 | Submission Open

Keywords: cardiomyopathy; heart failure; cardiac hypertrophy; dilated cardiomyopathy; restrictive cardiomyopathy; hypertrophic cardiomyopathy; ischemic cardiomyopathy; viral cardiomyopathy; inherited cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

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