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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Calcification in Human Diseases: Pathological Aspects and Therapeutic Strategies

edited by Antonella Bonetti

submission deadline 20 Oct 2024 | Viewed by 230 | Submission Open

Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Molecular to Systems Biology through Data Integration

edited by

Elvira Inglese

submission deadline 20 Oct 2024 | Viewed by 228 | Submission Open

Keywords: bioinformatic methods in systems biology; data-driven and dynamic modeling approaches; network analysis; data integration methods; digital twin; omics-based research; interactome analysis; network pharmacology

(This special issue belongs to the Section Molecular Informatics)

The Role of Phytochemicals in Cancer Treatment and Prevention

edited by

Michał Tomczyk

and

Jakub Strawa

submission deadline 20 Oct 2024 | Viewed by 227 | Submission Open

Keywords: cancer; cell culture; isolation and structure elucidation; metabolism; molecular mechanism; natural product chemistry; phytochemicals; secondary metabolites; structure– activity relationships; targeted therapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Progress in Cancer Cell Communications

edited by

Nan-Shan Chang

submission deadline 20 Oct 2024 | Viewed by 222 | Submission Open

Keywords: cancer cell; tumor microenvironment; tumorigenesis; signaling; binding proteins; miRNAs; therapeutic target

(This special issue belongs to the Section Molecular Oncology)

Apoptosis in Cancer Cells and New Targets for Cancer Therapy

edited by

Taeg Kyu Kwon

submission deadline 20 Oct 2024 | Viewed by 193 | Submission Open

Keywords: cancer cells; apoptosis; targeted cancer therapy; carcinogenesis; drug development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Applications of Nanostructured Materials in Electrochemical Sensing Technologies

edited by

Ching-Chou Wu

submission deadline 20 Oct 2024 | Viewed by 189 | Submission Open

Keywords: nanostructured materials; nano labels; electrode materials; electrochemical sensors; electrochemical biosensors

(This special issue belongs to the Section Materials Science)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 2nd Edition

edited by

Michael C. Levin

submission deadline 20 Oct 2024 | Viewed by 182 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Obesity: From Molecular Mechanisms to Clinical Aspects

edited by

Bunzo Matsuura

submission deadline 20 Oct 2024 | Viewed by 159 | Submission Open

Keywords: food intake; physical activity; adipose tissue; adipokines; gut hormones; nervous system; gut– brain axis; bariatric surgery; inflammation and immune response; genetics and epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Crosstalk between Bone and Inflammation

edited by Jessica Cottrell

submission deadline 20 Oct 2024 | Viewed by 159 | Submission Open

Keywords: bone; inflammation; immunology; bone metabolism; inflammatory disease

(This special issue belongs to the Section Molecular Immunology)

Mechanism of Enzyme Catalysis: When Structure Meets Function

edited by Ivana Leščić Ašler

submission deadline 25 Oct 2024 | 8 articles | Viewed by 8728 | Submission Open

Keywords: three-dimensional structure of enzymes; enzyme stability; solubility and flexibility; structure-function relationship in enzymes; mechanism of enzyme catalysis; enzyme kinetics; substrate specificity of enzymes; regulation of enzyme activity; enzyme engineering

(This special issue belongs to the Section Biochemistry)

Dental Health and Disease: From the Molecular and Pathological Perspectives

edited by

Ancuţa Goriuc

and

Ionut Luchian

submission deadline 25 Oct 2024 | 6 articles | Viewed by 5281 | Submission Open

Keywords: dental health; oral diseases; molecular mechanisms; pathological mechanisms; treatment perspectives; dentistry; oral medicine; oral pathology; physiopathology in dentistry; periodontal disease; oral fluids

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics and Epigenetics of Cardiometabolic Diseases

edited by

Péter Pikó

submission deadline 25 Oct 2024 | 2 articles | Viewed by 3456 | Submission Open

Keywords: obesity; insulin resistance; diabetes mellitus; cardiovascular diseases; metabolic syndrome; non-alcoholic fatty liver disease; dyslipidaemia; coronary artery disease; chronic kidney disease; hypertension

(This special issue belongs to the Section Molecular Genetics and Genomics)

Roles of Inflammasomes in Inflammatory Responses and Human Diseases

edited by

Young-Su Yi

submission deadline 25 Oct 2024 | 3 articles | Viewed by 3372 | Submission Open

Keywords: inflammasome; inflammatory responses; human diseases; anti-inflammatory therapeutics

(This special issue belongs to the Section Molecular Immunology)

Molecular and Cellular Mechanisms of Pancreatic Cancer

edited by

Sanith Cheriyamundath

submission deadline 25 Oct 2024 | 1 articles | Viewed by 2780 | Submission Open

Keywords: PDAC; metastasis; tumor microenvironment; cancer-associated fibroblasts; KRAS; immune cells; inhibitors; resistance; signaling pathways; EMT

(This special issue belongs to the Section Molecular Oncology)

Oxidative Stress: Cell Biology and Signal Transduction

edited by David González-Fores and

Javier Espino

submission deadline 25 Oct 2024 | 1 articles | Viewed by 2174 | Submission Open

Keywords: signalling molecules; reactive oxygen species; apoptosis; signal transduction; signalling network; second messenger; antioxidant molecules; oxidant agents

(This special issue belongs to the Section Molecular Biology)

Seed Reserve Mobilization: Unveiling Cellular and Molecular Mechanisms

edited by

Raquel Iglesias Fernandez

submission deadline 25 Oct 2024 | 1 articles | Viewed by 1622 | Submission Open

Keywords: seed germination; reserve mobilization; vesicle trafficking; protein storage vacuoles (PSVs); oleosomes; seed storage tissues (endosperm; perisperm; cotyledon)

(This special issue belongs to the Section Molecular Plant Sciences)

Cell Signaling and Molecular Pathology of Retinal Diseases : 2nd Edition

edited by

Hiroshi Tomita

submission deadline 25 Oct 2024 | 1 articles | Viewed by 1467 | Submission Open

Keywords: retinal degeneration; regenerative medicine; gene therapy; electroretinogram; visually evoked potential; RNA-seq; apoptosis; animal model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances and Perspectives in Rheumatic Diseases

edited by

Luciana Breda

submission deadline 25 Oct 2024 | 1 articles | Viewed by 1335 | Submission Open

Keywords: rheumatic diseases; molecular biology; inflammatory pathways; cytokines; molecular diagnostics; biologics; drug development; genetic factors; epigenetics; environmental influences

(This special issue belongs to the Section Molecular Immunology)

Medical Value of Metal Complexes and Plant-Derived Compounds: Biological Evaluation, Health Effects, Challenges, and Future Opportunities

edited by

Agnieszka Scibior

Juan Llopis

and

Manuel Aureliano

submission deadline 25 Oct 2024 | 2 articles | Viewed by 1319 | Submission Open

Keywords: bioactive compounds; metals; metal complexes; polyoxometalates; modern-age diseases; toxicity; therapeutic importance; novel applications

(This special issue belongs to the Section Molecular Pharmacology)

Skin Diseases: From Molecular Pathology to Novel Therapeutic Approaches

edited by

Alicja Forma

submission deadline 25 Oct 2024 | 1 articles | Viewed by 1265 | Submission Open

Keywords: skin physiology and pathology; skin cancer; autoimmune skin diseases; microbial infections of skin; sexually transmitted diseases; molecular pathology; therapeutic advancements

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Twist and Turn of Lipids in Human Diseases 2.0

edited by

Manoj Kumar Pandey

submission deadline 25 Oct 2024 | 2 articles | Viewed by 1146 | Submission Open

(This special issue belongs to the Section Molecular Immunology)

Recent Molecular Trends and Prospects in Kidney Diseases

edited by

Federico Greco

and

Carlo A. Mallio

submission deadline 25 Oct 2024 | 1 articles | Viewed by 1077 | Submission Open

Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Trends in Experimental Models for Cancer Research

edited by

Patrícia M. A. Silva

and

Cristina Pinto Ribeiro Xavier

submission deadline 25 Oct 2024 | 1 articles | Viewed by 1015 | Submission Open

Keywords: experimental models; cancer research; cell culture; animal models; organoids; computational models

(This special issue belongs to the Section Molecular Oncology)

Fish Nutrition, Metabolism and Physiology

edited by Fernando Naya-Català and Paula Simó-Mirabet

submission deadline 25 Oct 2024 | 1 articles | Viewed by 859 | Submission Open

Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; aquaculture

(This special issue belongs to the Section Molecular Biology)

Predictors of Response to Cancer Immunotherapy

edited by

Stephanie J. Tuminello

and

Emanuela Taioli

submission deadline 25 Oct 2024 | 1 articles | Viewed by 698 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitors; cancer; cancer therapy; precision medicine; survival outcomes

(This special issue belongs to the Section Molecular Immunology)

Signaling in Respiratory Diseases

edited by Tonio Pera

submission deadline 25 Oct 2024 | Viewed by 271 | Submission Open

Keywords: asthma; COPD; cystic fibrosis; GPCR; pharmacology; inflammation; airway remodeling

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis and Application of Nitrogen Heterocycles in the Treatment of CNS Disorders

edited by

Balraj Gopula

submission deadline 25 Oct 2024 | Viewed by 253 | Submission Open

Keywords: central nervous system (CNS); drug developmet; blood– brain barrier (BBB); nitrogen heterocycle; synthesis

(This special issue belongs to the Section Biochemistry)

GABA Signaling in Health and Disease in the Nervous System, 2nd Edition

edited by

Alexandre Hiroaki Kihara

submission deadline 25 Oct 2024 | Viewed by 229 | Submission Open

Keywords: gamma-aminobutyric acid; neurodevelopment; neuronal differentiation; neuronal disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms of Comorbidities in Rheumatic Diseases

edited by

Marino Paroli

submission deadline 25 Oct 2024 | Viewed by 215 | Submission Open

Keywords: inflammatory and autoimmune rheumatic diseases; comorbidities; autoimmunity; T-cell response

(This special issue belongs to the Section Molecular Immunology)

Novel Insights into Microglia Heterogeneity and Neurodegeneration

edited by

Maria Anttonietta Panaro

submission deadline 25 Oct 2024 | Viewed by 175 | Submission Open

Keywords: microglia; synapses; stress; aging; heterogeneity; CNS; single-cell RNA sequencing; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

New Molecular Insight into Solute Carrier Membrane Transporters Expressed in the Nervous System

edited by Elena Bossi

submission deadline 25 Oct 2024 | Viewed by 125 | Submission Open

Keywords: membrane transporters; SLC; transport system; transporter function; transporter regulation; transport-related diseases; pharmacokinetics; alternating access; conformational changes; transporters orthologs

(This special issue belongs to the Section Macromolecules)

New Perspective on Inflammatory Diseases: Role of Natural Compounds

edited by

Floriana D'Angeli

Carlo Genovese

and

Cristina Russo

submission deadline 27 Oct 2024 | 1 articles | Viewed by 1030 | Submission Open

Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Cellular Mechanisms of Retinal Diseases

edited by

Maria Consiglia Trotta

submission deadline 28 Oct 2024 | 1 articles | Viewed by 1032 | Submission Open

Keywords: retinopathies; diabetic retinopathy; inflammation; pro-resolving mediators; fibrosis; epithelial– mesenchymal transition; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Biology and Reactive Oxygen Species

edited by

Wieslawa Jarmuszkiewicz

submission deadline 28 Oct 2024 | Viewed by 232 | Submission Open

Keywords: mitochondrial biology; mitochondrial dysfunction; mitochondrial coenzyme Q; metabolic homeostasis; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Depression

edited by

Magdalena Sowa-Kućma

and

Katarzyna Stachowicz

submission deadline 30 Oct 2024 | 7 articles | Viewed by 16752 | Submission Open

Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors

(This special issue belongs to the Section Molecular Neurobiology)

Novel Therapeutic Targets of Solid Cancer

edited by

Valentina De Falco

submission deadline 30 Oct 2024 | 6 articles | Viewed by 12426 | Submission Open

Keywords: cancer; signal transduction; kinase inhibitors; targeted therapy; precision medicine; drug resistance; survival; cell cycle; cell reprogramming; stem cells; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Physiology and Molecular Biology of Plant Stress Tolerance

edited by

De-Guo Han

submission deadline 30 Oct 2024 | 12 articles | Viewed by 10144 | Submission Open

Keywords: plant– pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Polymeric Materials: From Synthesis to Applications

edited by

Marta Fernández-García

and

Alexandra Muñoz-Bonilla

submission deadline 30 Oct 2024 | 8 articles | Viewed by 9537 | Submission Open

Keywords: natural polymers; bio-based polymers; block copolymers; micelles; polymer chemistry; (hydro)gels; (bio)applications; degradability

(This special issue belongs to the Section Materials Science)

Molecular Advances on Insulin Resistance and Metabolic Dysfunction, 2nd Edition

edited by

Melania Manco

and

Amalia Gastaldelli

submission deadline 30 Oct 2024 | 3 articles | Viewed by 6243 | Submission Open

Keywords: dysregulated fatty acid and/or branched chain amino acids metabolism; metabolic inflexibility; tissue lipid accumulation; lipotoxicity and lipid mediated cell signaling; insulin resistance reversal; cancer development; low-grade inflammation and/or altered expression; synthesis and degradation and bioavailability of IGF binding proteins; environmental chemicals; mechanisms of T3D; microbiota and antimicrobials modulation; endocrine disruptors; altered immune system homeostasis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Relationship, Mechanisms, and Treatment Strategies of Diabetes Mellitus and Related Diseases

edited by Maria Kokozidou

submission deadline 30 Oct 2024 | 3 articles | Viewed by 4794 | Submission Open

Keywords: diabetes mellitus; molecular mechanisms; related diseases; genetic basis; microRNAs; incretins; targeted therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mesenchymal Stromal and Immune Cells’ Involvement in Human Diseases and Their Treatment

edited by

Mirjana Jerkic

submission deadline 30 Oct 2024 | 3 articles | Viewed by 3894 | Submission Open

Keywords: MSC homing; macrophages; lung injury; inflammation; sepsis; COVID-19; heart; liver; cell therapy

(This special issue belongs to the Section Molecular Immunology)

Antimicrobial Peptides and Immunology, 2nd Edition

edited by

Elena Chaves-Pozo

submission deadline 30 Oct 2024 | 2 articles | Viewed by 3598 | Submission Open

Keywords: antimicrobial peptides; immune regulation; macrophages; mast cells; granulocytes; neutrophiles; chemiotaxis; G-protein couple membrane receptors; inmunoadjuvants; T cell proliferation; cytokine regulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanism in the Pathogenesis of Alzheimer’s Disease and Related Neurodegenerative Diseases

edited by Kun Zou

submission deadline 30 Oct 2024 | 3 articles | Viewed by 3480 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative diseases; Parkinson’ s disease; amyotrophic lateral sclerosis; molecular mechanism; neuronal death; amyloid beta-protein; Tau; alpha-synuclein; TDP43

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Agro-Polymers

edited by

In Chul Um

submission deadline 30 Oct 2024 | 2 articles | Viewed by 2941 | Submission Open

Keywords: cellulose; lignin; starch; fibroin; sericin; keratin; soy; zein; pectin; collagen; biocompatibility; biodegradability

(This special issue belongs to the Section Materials Science)

Molecular Structure, Electronic and Vibrational Spectra: Experiment and Theoretical Calculations in Fundamental Science and Materials Science

edited by

Georgiy V. Girichev

submission deadline 30 Oct 2024 | 2 articles | Viewed by 2876 | Submission Open

Keywords: molecular structure; nature of chemical bonding; IR spectra; EA spectra; NMR; XRD; DFT; ab initio

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Role of Trace Elements in Nutrition and Health

edited by Jie Feng

submission deadline 30 Oct 2024 | 3 articles | Viewed by 2538 | Submission Open

Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Hepatitis Viruses and Hepatocellular Carcinoma: Research, Treatment and Challenges

edited by

Boyan Grigorov

submission deadline 30 Oct 2024 | 1 articles | Viewed by 2278 | Submission Open

Keywords: HBV; HDV; HCV; virus replication and pathogenesis; antivirals; virus– cell interaction; vaccine development; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Immunology)

Viral Infections and Host Immune Responses

edited by Barbara Ridolfi and Maria Teresa Maggiorella

submission deadline 30 Oct 2024 | 1 articles | Viewed by 2002 | Submission Open

Keywords: virus infections; virus– host interaction; innate immunity; adaptive immunity; host factors; co-infections; acute and chronic infections; restriction factors; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

Protein and Protein Interactions

edited by Wu Xu

submission deadline 30 Oct 2024 | 1 articles | Viewed by 1564 | Submission Open

Keywords: protein and protein interactions; ligand and protein interactions; computational method; geometry-based; energy-based; conformational changes; binding site prediction; structural biology; computational biology and bioinformatics

(This special issue belongs to the Section Molecular Biology)

Innovative Antimicrobial Therapies: Overcoming Virulence of Microorganisms and Drug Resistance

edited by

Anna Majewska

submission deadline 30 Oct 2024 | 2 articles | Viewed by 1555 | Submission Open

Keywords: antibiotics; antimicrobial resistance; antivirals; commensal; pathogenesis; virulence

(This special issue belongs to the Section Molecular Microbiology)

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