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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Drug Delivery Systems: Current Status in the Treatment of Human Diseases

edited by

Caterina Cinti

and

Pier Paolo Claudio

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1715 | Submission Open

Keywords: human diseases; cancer; cardiovascular disease; biomaterials; drug delivery; targeted therapies; theranostics

(This special issue belongs to the Section Molecular Pharmacology)

Editorial Board Members’ Collection Series: Cancer Metabolism

edited by

Giuseppe Lucarelli

Daniel W. Nixon

and

Gianfranco Peluso

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1706 | Submission Open

Keywords: cancer metabolism; metabolic pathway; glucose consumption and energy production; amino acid requirement

(This special issue belongs to the Section Molecular Oncology)

NK Cells, Immune Response in Pathology and Cancer, 2nd Edition

edited by

Isabel Legaz Pérez

and

Manuel Muro

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1689 | Submission Open

Keywords: cancer; NK cells; biomarkers; innate immune system

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Allergen Analysis

edited by

Christian Huck

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1675 | Submission Open

(This special issue belongs to the Section Molecular Biology)

Biofunctional Coatings for Medical Applications

edited by

Liviu Duta

Valentina Grumezescu

and

Gabriela Dorcioman

submission deadline 20 Jan 2025 | 2 articles | Viewed by 1654 | Submission Open

Keywords: biofunctional coatings; thin film deposition techniques; surface engineering; tissue engineering; materials’ doping and co-doping; medical applications

(This special issue belongs to the Section Materials Science)

Molecular Targeted Therapy for Gliomas

edited by Ka-Kit Leung

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1626 | Submission Open

Keywords: targeted therapy; glioma and glioblastoma; treatment strategies; identification of biomarkers; diagnosis; prognosis; molecular pathology; signalling pathways; molecular imaging; tumour microenvironment

(This special issue belongs to the Section Molecular Oncology)

Research on Advanced Bioanalytical Approaches for Biomolecules Detection

edited by

Almira Ramanaviciene

Anton Popov

and

Asta Kausaite-Minkstimiene

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1619 | Submission Open

Keywords: biosensors; immunosensors; immuno- or bio-assay; molecularly imprinted polymers; nanoparticles; biomarkers; analytical signal amplification strategies

(This special issue belongs to the Section Molecular Informatics)

Genomic Research in Neurobiology

edited by

Efthimios M. C. Skoulakis

and Katerina Papanikolopoulou

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1618 | Submission Open

Keywords: neuro-omics; GWAS; single-neuron approaches; neurodegenerative -omics; psychiatric -omics; omics validation models and systems

(This special issue belongs to the Section Molecular Neurobiology)

Stem Cells in Human Health and Diseases

edited by Dana Yehudai-Ofir

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1592 | Submission Open

Keywords: stem cells; stem cell biology; stem-cell-based therapy; stem cell regulation; cancer stem cell; tumor-initiating cell

(This special issue belongs to the Section Molecular Immunology)

Pulmonary Arterial Hypertension: From Molecular Mechanisms to Novel Therapeutic Approaches

edited by

Tatyana Novoyatleva

and

Akylbek Sydykov

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1572 | Submission Open

Keywords: pulmonary hypertension; right ventricular hypertrophy; right heart failure; pulmonary arterial hypertension; pulmonary vascular cells; endothelial dysfunction; adventitial fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Genetic Studies on Tourette Syndrome and Comorbid Disorders

edited by Jakub P. Fichna and Natalia Szejko

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1561 | Submission Open

Keywords: Tourette syndrome; genetics and genomics; molecular neurobiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroproteomics: Focus on Nervous System Function and Disease

edited by

Balázs András Györffy

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1556 | Submission Open

Keywords: proteomics; neuronal communication; pathomechanism of nervous system disorders; synapse; mass spectrometry

(This special issue belongs to the Section Molecular Neurobiology)

From Bench to Bedside: Well-Established and Emerging Preclinical Models in Cardiovascular Research

edited by

Laura Calvillo

and Veronica Dusi

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1548 | Submission Open

Keywords: myocardial infarction; organ ischemia and reperfusion injury; hypertension; cardiovascular dysfunction; cardio-renal syndrome; stroke; arrhythmias; heart disease; heart failure; genetic disorders; translational medicine; organoids; bioreactors; organs on a chip; omics sciences; pharmacology; molecular biology; gene therapy; quantum biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research of Phytochemicals in Health and Disease

edited by Sachiko Koyama,

Thomas Heinbockel

and

Vonnie Shields

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1507 | Submission Open

Keywords: phytochemicals with bioactive properties; health; brain function; regeneration; wound healing; treatment; and prevention of diseases; delivery routes and delivery methods; formulation of phytochemicals to overcome their hydrophobic nature and enhance their stability; drugs; supplements to drugs; and supplements for health maintenance; nourishment and phytochemicals; drug side effects; COVID-19

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research on Bio-Scaffold for Tissue Engineering

edited by

Raffaella Aversa

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1491 | Submission Open

Keywords: bone tissue engineering; biomechanically active scaffolds; metal additive scaffold manufacturing; structural bioresorbable materials; multiscale porous scaffolds; bioactive coatings and membranes; metallic smart biomaterials; ceramic smart biomaterials; polymeric smart biomaterials; biomechanics; biomimetics; nanocomposites; hybrid materials; bioresorbable ceramics; bioresorbable polymers; bioresorbable metals; polymer composites and nanomaterials; ceramic-polymeric hybrid systems; hybrid smart structures; functional biocoatings; new theoretical approaches for biomimetic material and prostheses; bionic prostheses based on smart materials; shape memory alloys

(This special issue belongs to the Section Materials Science)

Cancer: Molecular Research and Novel Inflammatory Targets

edited by

Sarah Adriana Scuderi

and

Alessia Filippone

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1488 | Submission Open

Keywords: cancer; tumor microenvironment; molecular biology; biomarkers; novel and alternative therapies; inflammation; pharmacological inhibitors

(This special issue belongs to the Section Molecular Oncology)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2025 | 2 articles | Viewed by 1429 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Autoimmune Diseases

edited by

Manuela Rizzi

and

Pier Paolo Sainaghi

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1402 | Submission Open

Keywords: autoimmune diseases; autoantibodies; biomarkers; immuno-inflammatory diseases; molecular pathways; translational research; molecular pathobiology; targeted therapy

(This special issue belongs to the Section Molecular Immunology)

Anemia and Iron Metabolism: Laboratory Diagnosis, Novel Biomarkers and Environmental Influence

edited by

Ariel Koren

and Carina Levin

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1391 | Submission Open

Keywords: anemia; iron metabolism; anemia of chronic diseases; iron deficiency; congenital anemias; hemoglobinopathies; iron overload

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insight into Therapeutic Potential of Targeted Nanoparticles

edited by

Aldo Nicosia

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1352 | Submission Open

Keywords: targeted nanoparticles; theranostics; bioimaging; targeted therapy; photothermal therapy; combination therapy; controlled release; reduced side effects

(This special issue belongs to the Section Molecular Nanoscience)

Sugar Signaling in Plants and Its Interaction with Phytohormones

edited by

Soulaiman Sakr

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1278 | Submission Open

Keywords: sugar sensing; sugar transduction pathway; interplay between sugar and hormone signaling pathways; abiotic stress; plant development; plant nutrition; epigenitic

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research and Treatment of Oral Diseases

edited by

Dorina Lauritano

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1216 | Submission Open

Keywords: oral medicine; oral biology; dentistry; molecular biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Magnetic Materials: Their Synthesis, Properties and Various Applications

edited by

Elżbieta Tomaszewicz

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1145 | Submission Open

Keywords: magnetic nanoparticles MNPs; nanoparticles synthesis; magnetic properties; superparamagnetism; molecular magnetism; magnetic resonance imaging (MRI); biomedical applications; magnetic hyperthermia; targeted drug delivery; tissue engineering

(This special issue belongs to the Section Materials Science)

Natural Compounds in Human Health and Disease

edited by

Kazuhiko Nakadate

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1131 | Submission Open

Keywords: nutrition; human health; obesity; polyphenol; tea; pathology; animal model

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microbial Metabolism and Enzymology: Insights into the Degradation of Organic Substrates by Environmental Bacteria

edited by

Elias R. Olivera

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1088 | Submission Open

Keywords: bacterial biodegradation; metabolism; enzymes; genomics; metabolomics; xenobiotics; aromatic compounds; alkanes; steroids; pollutants

(This special issue belongs to the Section Molecular Microbiology)

From Molecules to Medicines: Exploring Neurodegenerative Pathways for Targeted Neuropharmacology

edited by

Malgorzata Zaremba

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1036 | Submission Open

Keywords: disease modeling; drug studies; therapeutic interventions; neuropharmacology; innovative pharmacological interventions

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology and Targeted Therapies in Leukemias

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Jan 2025 | 1 articles | Viewed by 1027 | Submission Open

Keywords: molecular biology; target therapy; leukemia; TKI; BCL-2; FLT3; CAR-T cells; CML

(This special issue belongs to the Section Molecular Oncology)

Biomaterials and Antimicrobial Materials for Orthopaedic Application 2.0

edited by

Irena Maliszewska

submission deadline 20 Jan 2025 | 1 articles | Viewed by 954 | Submission Open

Keywords: biomaterials; antimicrobial materials; orthopaedic application; regenerative medicine; biocompatible polymers; scaffold tissue engineering; bone regeneration; spine; hydrogel; cryogel; stem cell

(This special issue belongs to the Section Materials Science)

Historic Genomics: An Emergent Discipline

edited by Antonio Arnaiz-Villena

submission deadline 20 Jan 2025 | Viewed by 938 | Submission Open

Keywords: history; genomics; mtDNA; Y chromosome; HLA; SNPs; STRs; genetic markers; full genome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Oxidants and Antioxidants in Molecular Sciences: 96 Years Anniversary since the Discovery of Folin-Ciocalteu Reagent

edited by

Simona Gabriela Bungau

and

Cosmin Mihai Vesa

submission deadline 20 Jan 2025 | Viewed by 924 | Submission Open

Keywords: oxidative stress; antioxidants; methods for determining oxidative stress; lipid peroxidation; protein oxidation; Folin– Ciocalteu method; oxidative stress impact on health

(This special issue belongs to the Section Biochemistry)

How Melanin Affects the Therapy Response of Cutaneous Melanoma?

edited by

Elena Andreucci

submission deadline 20 Jan 2025 | Viewed by 912 | Submission Open

Keywords: cutaneous melanoma; melanin; hyperpigmentation; tyrosinase; therapy resistance; molecular medicine; new therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Aluminium Adjuvants in Vaccines—A Way To Modulate the Immune Response

edited by

Håkan Eriksson

submission deadline 20 Jan 2025 | 1 articles | Viewed by 849 | Submission Open

Keywords: adjuvants and vaccines; innate immune activation; trained immunity; inflammatory response; cytokine modulation; phagosomes and intracellular signalling; epigenetic modulation

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Development and Cancer

edited by

Seb Dworkin

Charbel Darido

and

Tomasz Wilanowski

submission deadline 20 Jan 2025 | Viewed by 844 | Submission Open

Keywords: development; proliferation; embryogenesis; angiogenesis; epithelial– mesenchymal transition (EMT); stem cells; migration; differentiation; de-differentiation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Harnessing the Iatrogenic Autoimmune Forces by an Off-Label Low-Dose Combined Anti-CTLA-4 Plus Anti-PD-1 Antibody Blockade

edited by

Tibor Bakacs

submission deadline 20 Jan 2025 | Viewed by 674 | Submission Open

Keywords: immune checkpoint inhibitor (ICI) drugs; tolerance breakdown; uncontrolled T cell activation; immune-related adverse events (irAEs); harnessing autoimmune forces; low-dose anti-CTLA-4 and anti-PD-1 antibodies; mechanism of action of irAEs

(This special issue belongs to the Section Molecular Immunology)

Cyclin-Dependent Kinases: Their Role in Cell Physiology and Pathologies

edited by

Jacek Z. Kubiak

and

Malgorzata Kloc

submission deadline 20 Jan 2025 | Viewed by 650 | Submission Open

Keywords: cyclin-dependent kinases; cyclins; CDK inhibitors; cell cycle; cancers; transcription; mRNA processing; differentiation; embryo development

(This special issue belongs to the Section Biochemistry)

Nano for Health: Strategies and Challenges of Nanotechnology for Drug Delivery

edited by

Dragana Barros

and

Catarina Pinto Reis

submission deadline 20 Jan 2025 | Viewed by 630 | Submission Open

Keywords: nanotechnology; drug delivery; therapeutic and diagnostics nanoplatforms; cell interaction; toxicity; biodistribution; pharmacokinetics; in vitro and in vivo models; in silico models; scale-up manufacturing; regulatory framework

(This special issue belongs to the Section Molecular Nanoscience)

Mendel's and Wallace's 200 Year Anniversary–Modern Synthesis in the Genomics Era

edited by

Andrés J. Cortés

submission deadline 20 Jan 2025 | Viewed by 579 | Submission Open

Keywords: biodiversity; quantitative genetics; molecular genetics; comparative genomics; modeling; big data; omics; genomic prediction; machine learning

(This special issue belongs to the Section Molecular Genetics and Genomics)

Modern Analytical Strategies for Foodomics: From Nutritional Value to Food Security

edited by

Cosima Damiana Calvano

submission deadline 20 Jan 2025 | Viewed by 551 | Submission Open

Keywords: food adulteration; food authenticity; mass spectrometry; spectroscopic techniques; method development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Biodegradable Polymers: From Chemical Synthesis to Biodegradable Mechanism

edited by

Ling-Ping Xiao

Oana Lelia Pop

and

Gabrijel Ondrasek

submission deadline 20 Jan 2025 | Viewed by 531 | Submission Open

Keywords: biodegradable polymers; polyolefins; molecular structures; synthesis; chemical modification; hydrolysis kinetics

(This special issue belongs to the Section Macromolecules)

Tumor Microenvironment in Cancer Cell Metastasis

edited by

Vasiliki Gkretsi

submission deadline 20 Jan 2025 | Viewed by 510 | Submission Open

Keywords: tumour microenvironment; extracellular matrix; actin cytoskeleton; cancer cell metastasis

(This special issue belongs to the Section Molecular Oncology)

NMR Tools and Their Application for Structural Biology of Bioactive Proteins 2.0

edited by

Orsolya Tőke

and

Gyula Batta

submission deadline 20 Jan 2025 | Viewed by 501 | Submission Open

Keywords: protein interactions; ligand binding; molecular recognition; conformational transitions; allostery; intrinsically disordered proteins; protein dynamics; protein aggregation; membrane proteins; biofilms

(This special issue belongs to the Section Molecular Biophysics)

Research on Active Molecules and Natural Products

edited by

Agnieszka Gȩgotek

submission deadline 20 Jan 2025 | Viewed by 493 | Submission Open

Keywords: natural products; active molecules; bioactive compounds; therapeutic potential; cutting-edge techniques; isolation; identification; characterization; biomedical applications; drug discovery

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanism of Plant Mineral Nutrient Transport under Drought Stress

edited by

Stefania Astolfi

submission deadline 20 Jan 2025 | Viewed by 480 | Submission Open

Keywords: assimilation; climate change; drought; nutrients; transport; transporters; uptake

(This special issue belongs to the Section Molecular Plant Sciences)

Synthesis, Properties and Applications of Alloy Materials

edited by

Vishal Soni

and

Mayur Pole

submission deadline 20 Jan 2025 | Viewed by 479 | Submission Open

(This special issue belongs to the Section Materials Science)

Lung Diseases and Lung Transplantations: Molecular Pathogenesis and Advanced Therapies

edited by Christopher Lambers

submission deadline 20 Jan 2025 | Viewed by 441 | Submission Open

Keywords: lung disease; lung transplantation; ECMO; EVLP; LAS; antibody-mediated rejection (AMR); CLAD; RAS/BOS; immunosuppression; pathogenesis; cell-free DNA; IPF therapies; gene therapies; stem cell therapies; immunotherapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancer: Molecular Mechanism and Treatment Strategies

edited by

Pina Ziranu

submission deadline 20 Jan 2025 | Viewed by 437 | Submission Open

Keywords: colorectal cancer; personalized treatment; treatment strategies; cancer biology

(This special issue belongs to the Section Molecular Oncology)

Structure-Function Studies on Human Aromatase and Role in Pathologies

edited by Giovanna Di Nardo and