Psoriatic Arthritis—New Insights, Challenges, Unmet Needs and Controversies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 22 November 2024 | Viewed by 683

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Guest Editor
Department of Internal Medicine and Rheumatology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: autoimmune disorders; inflammatory diseases; biologicals; connective tissue disorders; spondyloarthitis
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Special Issue Information

Dear Colleagues,

Psoriatic arthritis, as part of the whole psoriatic disease spectrum, is one of the most challenging immune-mediated inflammatory diseases (IMIDs). This is mainly due to the large heterogeneity of clinical rheumatological expression and its destructive potential, but also to the association of extra-musculoskeletal manifestations and comorbidities that could impact patient perspectives. The complexity of this condition explains the frequent need to utilize multidisciplinary teams, including rheumatologists, dermatologists, internal medicine specialists, cardiologists, psychotherapists, and more. Fortunately, it can be said without exaggeration that recent years have brought amazing therapeutic advances that have significantly changed the management and prognosis of these patients.

This Special Issue focuses on the latest advances in pathogenesis and treatment but also on clinical and management challenges, unmet needs, and controversies. The goal is to significantly improve knowledge about psoriatic disease and, consequently, to contribute to a better patient prognosis.

We kindly invite you to submit your original research, review articles, and spectacular case reports for this Special Issue.

Dr. Daniela Opris-Belinski
Guest Editor

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Keywords

  • psoriatic arthritis
  • psoriasis
  • enthesitis
  • dactylitis
  • spondyloarthritis
  • radiological progression
  • biologics
  • JAK-inhibitors
  • immune-mediated inflammatory diseases
  • comorbidities

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Published Papers (1 paper)

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Research

11 pages, 1117 KiB  
Article
Additional Value of Ultrasound in Patients with Psoriatic Arthritis within Treatment Target
by Mihaela Agache, Claudiu C. Popescu, Luminița Enache, Corina Mogoșan, Emilio Filippucci and Cătălin Codreanu
J. Clin. Med. 2024, 13(15), 4567; https://doi.org/10.3390/jcm13154567 - 5 Aug 2024
Viewed by 457
Abstract
Background: In psoriatic arthritis (PsA), musculoskeletal ultrasound is a complementary tool to physical examination, useful even in patients in remission to detect subclinical activity. Objectives: The objective of the study was to assess the ultrasound prevalence of active enthesitis and synovitis in patients [...] Read more.
Background: In psoriatic arthritis (PsA), musculoskeletal ultrasound is a complementary tool to physical examination, useful even in patients in remission to detect subclinical activity. Objectives: The objective of the study was to assess the ultrasound prevalence of active enthesitis and synovitis in patients who reached the therapeutic target. Methods: This cross-sectional study included patients with at least 6 months of therapy with a targeted synthetic or biological disease-modifying antirheumatic drug who were in treatment target (i.e., DAPSA < 14). Patients underwent bilateral clinical and ultrasound examination of the elbow lateral epicondyle, quadriceps insertion, distal patellar tendon insertion, and Achilles enthesis for assessing enthesitis, and hand and foot joints for assessing synovitis. Enthesitis and synovitis were considered active if the power Doppler signal showed at least a score of one. Results: The study included 51 PsA patients, women (52.9%), with an average age of 55 years. Although the patients were within the DAPSA treatment target, 21.6% had at least one painful enthesis at clinical examination, 19.6% had ultrasound evidence of at least one active enthesitis and 15.7% had ultrasound signs of at least one active synovitis. Conclusions: Among PsA patients thought to be within the therapeutic target, ultrasound detected a non-negligible percentage of active enthesitis and synovitis. Full article
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