Various Causes of Pulmonary Hypertension: A Multidisciplinary Approach

Dear Colleagues,

Pulmonary hypertension (PH) is a hemodynamic state defined as a mean pulmonary artery pressure of ≥25 mm Hg assessed by right heart catheterization at rest. PH can be the consequence of different clinical conditions, which translate into the five groups used in the WHO classification: (1) Pulmonary artery hypertension (PAH), (2) left-heart disease, (3) lung disease/hypoxemia, (4) chronic thromboembolic PH (CTEPH), and (5) PH with unclear and/or multifactorial mechanisms. PH patients are often treated by a team of PH specialists, pulmonary physicians, cardiologists, immunologists/rheumatologists, and specialist PH nurses. There are multiple pathological drivers of PH, including abnormal proliferation, inflammation, metabolism, neurohumoral, oxidative stress, and dysregulation of vascular tone.

For an upcoming Special Issue in the Journal of Clinical Medicine (PubMed indexed), we invite investigators to contribute original research articles (including human and animal studies; experimental and/or translational research will be given priority), as well as review articles that will stimulate the continuing efforts to get an early diagnosis, to gain new insights into pathobiological mechanisms, as well as to improve treatment of PH and quality of life.

Potential topics may include but are not limited to:

• Early diagnostic markers of different classes of PH;
• Genetics in PH;
• Cellular, molecular, and/or hemodynamic mechanisms that drive PH;
• Effect of thrombus formation/composition on the development of PH;
• Potential new treatments for PH;
• Improving quality of life of patients with PH.

Dr. Mirjam Kool
Dr. Daphne Merkus
Dr. Karin Boomars
Guest Editors

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