(Lastest Advances) Reconditioning Strategies in Solid Organ Transplantation: Linking Theory to Clinical Practice
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 19567
Special Issue Editors
2. Department of HPB Surgery, Università degli Studi, Milan, Italy
Interests: machine perfusion; liver transplantation; ischemia-reperfusion injury; preclinical research
Interests: machine perfusion; liver transplantation; ischemia-reperfusion injury; role of mitochondria
Interests: metabolomics; nutrition; hepatology; cell metabolism; personalized medicine; ischemia/reperfusion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In our field, we are daily faced with the increasing number of patients waiting for solid organ transplantation and with a higher number of donors of impaired quality, based on the evolution of donor characteristics. One key issue today appears with the impaired utilization of our donor pool. The area of organ preservation is therefore currently shifting, and new technologies are not only tested in studies, but also implemented in routine clinical practice as new standard of care for such risky donors or to bridge difficult logistical situations. The most successful and widely used perfusion technique will be the approach, which enables the use of risky donors and maintain the good post-transplant outcomes we have achieved today.
Three main concepts are currently tested in clinical studies in different western countries, where a few concepts became recently commissioned for specific donors. From in-situ preservation and evaluation techniques (e.g. normothermic regional perfusion), we have learned that an early assessment of organs at the beginning of the preservation is beneficial and a useful selection tool. The ex-situ concepts appear most beneficial for risky grafts, when the cold ischemic times prior to perfusion are short and reduce the additional ischemic injury. In contrast, hypothermic oxygenated perfusion (HOPE/D-HOPE) have been identified to improve organ quality and reduce ischemia-reperfusion injury and related complications after transplantation. All techniques, and their combinations significantly contribute to the field and the task to identify the optimal technology, particularly for smaller centers who aim to start a new perfusion program, appears not easy. A thorough understanding of underlying mechanisms of protection and injury is therefore the key to provide the best preservation for our patients and to identify the next and most important trials required to move the entire field forward.
This special issue aims therefore to present articles, which explore and critically discuss new aspects of perfusion technology. Experimental and clinical studies that report innovative approaches will increase the knowledge, particularly as translational approaches when they may serve as a link between theory and clinical practice to trigger ideas for new clinical studies with a focus on the patient needs.
Dr. Daniele Dondossola
Dr. Andrea Schlegel
Dr. Caterina Lonati
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- reconditioning
- machine perfusion
- extended criteria donor
- translational study
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.