Chronic Heart Failure in Perspective

Dear Colleagues,

Heart failure (HF) is a multifactorial and heterogeneous syndrome for which significant therapeutic progress has been made based on clinical trials. Presently, clinical development regarding this pathology is actively pursued. The application of biomarkers, the contribution of cardiac multimodality imaging, the use of telemedicine, and the incorporation of new molecules and devices in the treatment of heart failure require constant updating. Moreover, while a therapy based on neurohumoral modulation appears to be effective in the treatment of HF with reduced left ventricular ejection fraction (HFrEF), it is not fully functional for HF with preserved left ventricular ejection fraction (HFpEF), and the demonstration of a marginal benefit in the latter case required meta-analyses and post-hoc analyses of classic trials that originally produced neutral results. In fact, HFpEF is currently considered the largest unmet challenge in cardiology.

The present Special Issue aims to explore new aspects that may contribute to the management of this complex syndrome.

We would be honored to have robust contributions from heart failure experts in order to update the scientific literature on this important and complex topic.

Prof. Dr. Juan F. Delgado Jiménez
Guest Editor

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