Advances and Challenges in Pharmacogenomics

Dear Colleagues,

Pharmacogenomics has the goal of improving therapeutic outcomes, increasing the efficacy of medications, and reducing adverse events by applying knowledge of patients’ genetic profiles. Reproducible associations between interindividual variability in clinical response to medications and genetic variants have been reported for several drugs; however, implementation of this knowledge to improve therapeutic outcomes is still limited. This is due to several factors, among which include the need for improved resources and training about pharmacogenetics dedicated to health care providers, the need of clear guidelines on how to apply pharmacogenetic information to tailor drug therapy, the challenges of handling pharmacogenetics information in the everyday context of a polypharmacy treatment and of better understanding the molecular mechanisms  that are at the basis of the association between genetic variants and interindividual variability in drug effects.

For this Special Issue, we welcome reviews and original articles covering many aspects of pharmacogenomics. These include, but are not limited to, resources and strategies to increase pharmacogenomic knowledge among health care providers, tools to support the clinical implementation of pharmacogenomics in the clinical practice, the role of drug–drug interactions in the pharmacogenomic field, and research on new pharmacogenomics markers to increase drug efficacy and safety, in particular considering the contribution of epigenetic markers. We look forward to your contributions.

Dr. Erika Cecchin
Dr. Gabriele Stocco
Guest Editors

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