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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Treatment of Bladder Cancer: From Past to Future
edited by Jørgen Bjerggaard Jensen
submission deadline 31 Jan 2025 | 2 articles | Viewed by 2438 | Submission Open
Keywords: urology; bladder cancer; urothelial cancer; nonmuscle-invasive bladder cancer; muscle-invasive bladder cancer
(This special issue belongs to the Section Oncology)
Current Advances and Challenges in Urological Surgery Using Laser Technologies
edited by Frédéric Panthier and
submission deadline 31 Jan 2025 | 2 articles | Viewed by 2213 | Submission Open
Keywords: laser; urinary stones; upper tract urothelial carcinoma; benign prostatic hyperplasia; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
New Insights into Melanoma and Non-Melanoma Skin Cancers
edited by
submission deadline 31 Jan 2025 | 2 articles | Viewed by 2180 | Submission Open
Keywords: melanoma; non-melanoma skin cancers (nmsc); basal cell carcinoma (bcc); squamous cell carcinoma (scc); actinic keratosis (ak); prevention and early detection; genetic; artificial intelligence; telemedicine; immunotherapy and targeted therapy
(This special issue belongs to the Section Dermatology)
Corneal Surgery: Latest Advances and Prospects
edited by Augusto Pocobelli and
submission deadline 31 Jan 2025 | 2 articles | Viewed by 2126 | Submission Open
Keywords: corneal surgery; corneal diseases; deep anterior lamellar keratoplasty; descemet stripping automated endothelial keratoplasty; descemet membrane endothelial keratoplasty; keratoconus; eye bank
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Reconstructive Surgery: Innovations and Outcomes for Improved Patient Care
edited by Rami S. Kantar
submission deadline 31 Jan 2025 | 3 articles | Viewed by 1935 | Submission Open
Keywords: reconstructive surgery; clinical advances; innovations; surgical outcomes; patient care; cleft lip repair; breast reconstruction; facial reconstruction; hand surgery; burn reconstruction; minimally invasive procedures; patient-specific treatment planning; anesthesia and pain management; regenerative medicine
(This special issue belongs to the Section General Surgery)
Recent Advances in Minimally Invasive Gynecologic Surgery (MIGS)
edited by Laurenţiu Cornel Pirtea, and Răzvan Ciortea
submission deadline 31 Jan 2025 | 2 articles | Viewed by 1860 | Submission Open
Keywords: laparoscopy; urogynecology; oncologic surgery; minimally invasive surgery
(This special issue belongs to the Section Obstetrics & Gynecology)
Immune Dysregulation in Inborn Errors of Immunity: From Allergy to Autoimmunity and Lymphoproliferation submission deadline 31 Jan 2025 | 2 articles | Viewed by 1846 | Submission Open
Keywords: immune dysregulation; immunodeficiency; autoimmunity; allergy; lymphoproliferation; inborn errors of immunity
(This special issue belongs to the Section Immunology)
Advances in the Diagnosis, Treatment, and Prognosis of Aortic Stenosis
edited by Rita Milewski
submission deadline 31 Jan 2025 | 1 articles | Viewed by 1818 | Submission Open
Keywords: aortic valve stenosis; aortic valve replacement; surgical aortic valve replacement; transfemoral aortic valve replacement; risk stratification for aortic stenosis
(This special issue belongs to the Section Cardiology)
Chronic Obstructive Pulmonary Disease (COPD)—Clinical Aspects, Early Detection and Pathogenesis
edited by , Yochai Adir and Ariel Rokach
submission deadline 31 Jan 2025 | 2 articles | Viewed by 1782 | Submission Open
Keywords: COPD; pathophysiology; pulmonary function test; acute exacerbation; neutrophils; eosinophils; early detection
(This special issue belongs to the Section Pulmonology)
Clinical Management of Spinal Tumor: Surgical Treatment, Radiotherapy and Systemic Therapy
edited by Riccardo Ghermandi and
submission deadline 31 Jan 2025 | 1 articles | Viewed by 1626 | Submission Open
Keywords: primary spinal tumors; metastatic spinal disease; surgery; radiotherapy; systemic therapy
(This special issue belongs to the Section Oncology)
Causes and Advanced Treatments of Macular Edema submission deadline 31 Jan 2025 | 1 articles | Viewed by 1444 | Submission Open
Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT
(This special issue belongs to the Section Ophthalmology)
The Clinical Role of Imaging in Lung Diseases
edited by and Claire Van Ngoc Ty
submission deadline 31 Jan 2025 | 1 articles | Viewed by 1425 | Submission Open
Keywords: lung screening; lung cancer; acute respiratory distress; pulmonary embolism; chronic obstructive pulmonary disease; imaging
(This special issue belongs to the Section Pulmonology)
Advances in Epidemiological and Statistical Methods for Clinical Research submission deadline 31 Jan 2025 | 1 articles | Viewed by 1080 | Submission Open
Keywords: epidemiology; biostatistics; clinical research; statistical methodologies; causal inference; meta-analysis; observational studies; prediction models; study designs; data analysis; bias and confounding; evidence-based medicine
(This special issue belongs to the Section Clinical Research Methods)
Rare Respiratory Diseases: A Personal and a Public Health Problem: 3rd Edition
edited by
submission deadline 31 Jan 2025 | 1 articles | Viewed by 852 | Submission Open
Keywords: rare diseases; rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis; lymphangioleiomyomatosis; interstitial lung diseases; pulmonary arterial hypertension
(This special issue belongs to the Section Pulmonology)
Clinical Advances in Cardiothoracic Anesthesia
edited by Eleni Arnaoutoglou and Metaxia V. Bareka
submission deadline 31 Jan 2025 | 1 articles | Viewed by 802 | Submission Open
Keywords: cardiac anesthesia; perioperative medicine; outcome; regional anesthesia; novel pharmacological agents; minimally invasive surgical methods; enhanced recovery; patient safety
(This special issue belongs to the Section Anesthesiology)
Clinical Application of Radiotherapy in Modern Oncology submission deadline 31 Jan 2025 | 1 articles | Viewed by 770 | Submission Open
Keywords: brain metastasis; bone metastasis; brain tumors; head and neck cancers; thoracic oncology; breast cancer; prostate cancer; sarcoma
(This special issue belongs to the Section Oncology)
Innovative Research on Thyroid Cancer Diagnosis and Therapy
edited by Domenico Parmeggiani
submission deadline 31 Jan 2025 | Viewed by 467 | Submission Open
Keywords: thyroid cancer; nuclear medicine; thyroid surgery; minimally invasive surgery; cytopathology; gene panel endocrinology; nodule thermal ablation; artificial intelligence
(This special issue belongs to the Section Oncology)
Male Fertility in the Modern Age: Challenges and Opportunities
edited by Angelo Marino
submission deadline 31 Jan 2025 | Viewed by 412 | Submission Open
Keywords: male infertility; semen parameters; sperm selection; IVF/ICSI
(This special issue belongs to the Section Reproductive Medicine & Andrology)
New Discoveries and Future Trends for Renal Transplantation: From Diagnosis to Treatment
edited by and Ayman Al Jurdi
submission deadline 31 Jan 2025 | Viewed by 365 | Submission Open
Keywords: kidney transplant; transplant immunology; recurrent glomerular disease; clinical trials; rejection; crossmatching; allocation; CMV; BK nephropathy
(This special issue belongs to the Section Nephrology & Urology)
Differential Effects of Bariatric Surgery (BS) and Endoscopic Bariatric Therapy (EBT) on Long and Short-Term Metabolic Outcomes
edited by Mohamad Mokadem
submission deadline 31 Jan 2025 | Viewed by 270 | Submission Open
Keywords: obesity; bariatric surgery; endoscopic bariatric therapy; metabolic surgery; weight loss; metabolism; weight management
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Advances in Assisted Reproductive Technology submission deadline 31 Jan 2025 | Viewed by 260 | Submission Open
Keywords: assisted reproductive technology (ART); fertility; pregnancy; in vitro fertilization (IVF); intracytoplasmic sperm injection (ICSI); multidisciplinary approach; reproductive endocrinologists; embryologists
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Hernia Surgery and Postoperative Management
edited by Jacob Rosenberg
submission deadline 31 Jan 2025 | Viewed by 243 | Submission Open
Keywords: hernia surgery; hernia repair; abdominal hernia; preoperative; intraoperative; postoperative; management; complications
(This special issue belongs to the Section General Surgery)
Current Concepts in Diagnosis and Therapy of Aortic Valve Disease
edited by Robert Zilberszac and Lore Schrutka
submission deadline 31 Jan 2025 | Viewed by 230 | Submission Open
Keywords: aortic valve disease; echocardiography and other imaging modalities; transcatheter aortic valve replacement (TAVR); surgical aortic valve replacement (SAVR); prevention; patient-specific treatment
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Updates on Perioperative Pain Management: 2nd Edition submission deadline 31 Jan 2025 | Viewed by 222 | Submission Open
Keywords: anesthesia and intensive care; pain management; spinal anesthesia; postoperative pain; breast surgery; fascial plane blocks; abdominal surgery; cardiac surgery; thoracotomy; knee surgery; orthopedic surgery; hip surgery; ultrasound
(This special issue belongs to the Section Anesthesiology)
Advancements in Optical Diagnostics for Head and Neck: Current Trends and Future Directions
edited by
submission deadline 31 Jan 2025 | Viewed by 205 | Submission Open
Keywords: head and neck cancer; head and neck surgery; fluorescence imaging; Raman spectroscopy; optical coherence tomography; photoacoustic imaging; photodiagnosis; photodynamic therapy
(This special issue belongs to the Section Otolaryngology)
Multimodality Imaging and Computational Modelling for the Invasive Treatment of Arrhythmias and Heart Failure
edited by Uyen Chau Nguyen and Pranav Bhagirath
submission deadline 31 Jan 2025 | Viewed by 205 | Submission Open
Keywords: arrhythmias; heart failure; cardiomyopathy; computational modelling; digital twin; electrocardiographic imaging; electro-anatomic mapping; cardiac magnetic resonance imaging; (photon counting) computed tomography; segmentation and mesh generation; image integration; image registration; artificial intelligence; deep learning
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Hip Fracture and Surgery: Clinical Updates and Challenges
edited by
submission deadline 31 Jan 2025 | Viewed by 193 | Submission Open
Keywords: antiosteoporosis medication; fracture liaison service; osteosynthesis; total hip arthroplasty; hemiarthroplasty
(This special issue belongs to the Section Orthopedics)
Perioperative Management in Thoracic Surgery
edited by
submission deadline 31 Jan 2025 | Viewed by 190 | Submission Open
Keywords: thoracic surgery; perioperative care; preoperative assessment; postoperative management; pain management; surgical outcomes; multidisciplinary approach; pharmacological innovations; patient safety; technology in surgery
(This special issue belongs to the Section Pulmonology)
Diabetic Nephropathy: Advances in Pathogenesis and Novel Therapies
edited by Meritxell Ibernon
submission deadline 31 Jan 2025 | Viewed by 184 | Submission Open
Keywords: pathogenesis of diabetic nephropathy; novel therapies; risk factors for disease progression; proteomic approach; serologic biomarkers; histological classification
(This special issue belongs to the Section Nephrology & Urology)
Clinical Updates on Haemophilia
edited by Irene Ricca
submission deadline 31 Jan 2025 | Viewed by 153 | Submission Open
Keywords: haemophilia; early prophylaxis; non-replacement therapy; gene therapy; joint status; quality of life; patient-reported outcomes
(This special issue belongs to the Section Hematology)
Physiotherapy Update in the Management of Musculoskeletal Pain submission deadline 1 Feb 2025 | 3 articles | Viewed by 4538 | Submission Open
Keywords: musculoskeletal pain; diagnosis; musculoskeletal ultrasound; dry needling; manual therapy; therapeutic exercise; pain education
(This special issue belongs to the Section Anesthesiology)
The Role of Bayesian Methods in Clinical Medicine
edited by Nicolas Meyer
submission deadline 6 Feb 2025 | Viewed by 164 | Submission Open
Keywords: bayesian statistics; clinical trials; epidemiology; clinical epidemiology; decision; diagnostic test; master protocol; review; statistical controversies; adaptive design
(This special issue belongs to the Section Clinical Research Methods)
Clinical Advances in Extracorporeal Membrane Oxygenation (ECMO)
edited by and Akram Zaaqoq
submission deadline 9 Feb 2025 | 2 articles | Viewed by 4534 | Submission Open
Keywords: extracorporeal membrane oxygenation; ECMO; multi-organ failure; outcomes; V-A ECMO; ECPR; V-V ECMO; translational research; clinical research
(This special issue belongs to the Section Intensive Care)
Advances in Endoscopic Ultrasound for Pancreatic Diseases submission deadline 10 Feb 2025 | 2 articles | Viewed by 6966 | Submission Open
Keywords: endoscopic ultrasound (EUS); pancreatic diseases; interventional EUS; endoscopic retrograde cholangiopancreatography (ERCP); EUS-guided procedures; diagnosis and treatment
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
State of the Art: Catheter Ablation of Atrial Fibrillation
edited by and Cinzia Monaco
submission deadline 10 Feb 2025 | 3 articles | Viewed by 3367 | Submission Open
Keywords: atrial fibrillation; catheter ablation; pulsed-field ablation; supraventricular arrhythmias; atrial substrate
(This special issue belongs to the Section Cardiovascular Medicine)
Endovascular Management of Diseases of the Aorta: From the Aortic Valve to the Iliac Arteries
edited by , Simona Sica and
submission deadline 10 Feb 2025 | 2 articles | Viewed by 3250 | Submission Open
Keywords: aortic dissection; aortic aneurysm; aortic valve disease; iliac artery disease; atherosclerosis; atherosclerosis; endovascular surgery
(This special issue belongs to the Section Vascular Medicine)
New Perspectives on the Diagnosis and Treatment of Liver Cirrhosis
edited by Elba Llop
submission deadline 10 Feb 2025 | 2 articles | Viewed by 1957 | Submission Open
Keywords: liver cirrhosis; portal hypertension; non-invasive diagnosis; elastography; gastro-esophagueal varices
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Heart Disease and Chronic Inflammatory Conditions: New Insights
edited by Ofer Kobo and Gilad Margolis
submission deadline 10 Feb 2025 | 1 articles | Viewed by 1284 | Submission Open
Keywords: heart diseases; chronic inflammatory; rheumatoid arthritis; cardiovascular disease; inflammatory bowel disease
(This special issue belongs to the Section Cardiology)
Assisted Reproductive Technology: Recent Developments and Future Perspectives
edited by , and Ulrik Schiøler Kesmodel
submission deadline 10 Feb 2025 | Viewed by 270 | Submission Open
Keywords: assisted reproductive technology (ART); infertility; recurrent miscarriage; selection techniques; artificial intelligence
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Endoscopic Techniques in Digestive and Gynecological Diseases
edited by , Teresa Mascarenhas and
submission deadline 11 Feb 2025 | 3 articles | Viewed by 5479 | Submission Open
Keywords: endoscopy; gastroenterology; gynecology; colonoscopy; colposcopy; artificial intelligence; capsule endoscopy; upper endoscopy; hysteroscopy; pancreatobiliary endoscopy
(This special issue belongs to the Section General Surgery)
Catheter Ablation for Cardiac Arrhythmias: Clinical Updates and Perspectives in Cardiac Electrophysiology
edited by Karolina Weinmann-Emhardt, Ingo Staudacher and Jonas Wormann
submission deadline 13 Feb 2025 | 1 articles | Viewed by 1586 | Submission Open
Keywords: electrophysiology; arrhythmia; atrial fibrillation; atrial flutter; ablation; 3D mapping; pulsed field ablation; radiofrequency ablation; pulmonary vein isolation
(This special issue belongs to the Section Cardiovascular Medicine)
Increasing the Efficacy of Neurorehabilitation: From the Translationality of Technology to Personalized Rehabilitation Medicine submission deadline 14 Feb 2025 | 7 articles | Viewed by 11858 | Submission Open
Keywords: rehabilitation; translationality; personalized medicine; brain disorders; exoskeleton; artificial intelligence; technology; assessment; robot-assisted training; brain computer interface; virtual reality
(This special issue belongs to the Section Clinical Rehabilitation)
Trends and Prospects in Shoulder and Elbow Surgery
edited by Lorenzo Diaz Balzani, Erika Albo, and
submission deadline 14 Feb 2025 | 1 articles | Viewed by 1387 | Submission Open
Keywords: shoulder; elbow; arthroplasty; arthroscopy; rehabilitation; trauma; minimally invasive; regenerative medicine; implant technology
(This special issue belongs to the Section Orthopedics)
Catheter Ablation of Cardiac Arrhythmias: Current Updates and Perspectives
edited by
submission deadline 15 Feb 2025 | 9 articles | Viewed by 14378 | Submission Open
Keywords: ablation; arrhythmia; electrophysiology; atrial fibrillation; atrial flutter; atrial tachycardia; mapping; supraventricular tachycardia; ventricular arrhythmia
(This special issue belongs to the Section Cardiovascular Medicine)
Type 2 Diabetes and Complications: From Diagnosis to Treatment
edited by Matteo Monami
submission deadline 15 Feb 2025 | 10 articles | Viewed by 11993 | Submission Open
Keywords: type 2 diabetes; diabetic foot ulcer; cardiovascular disease; microvascular complications; glycemic control
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Applications of Endoscopic Technology in Pancreaticobiliary Disease
edited by
submission deadline 15 Feb 2025 | 1 articles | Viewed by 4891 | Submission Open
Keywords: pancreatitis; difficult ERCP; third-space endoscopy including POEM and G-POEM; ESD; gastroesophageal reflux disease; endoscopy; transoral incisionless fundoplication (TIF)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Amyloid: From Heart to Brain submission deadline 15 Feb 2025 | 1 articles | Viewed by 1035 | Submission Open
Keywords: amyloid; heart; brain; interactions; small vessel disease; takotsubo; Alzheimer’ s disease
(This special issue belongs to the Section Cardiology)
New Insights into Lung Imaging
edited by
submission deadline 15 Feb 2025 | 1 articles | Viewed by 758 | Submission Open
Keywords: lung disease; lung cancer; chest-CT; chest X-ray; imaging
(This special issue belongs to the Section Pulmonology)
Advances in Endoscopic Management of Pancreatobiliary Neoplasms
edited by and Michiel Bronswijk
submission deadline 15 Feb 2025 | Viewed by 295 | Submission Open
Keywords: ERCP; EUS; therapeutic EUS; cholangioscopy; LAMS; gastric outlet obstruction; jaundice; cholecystitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Application of Magnetic Resonance Imaging (MRI) in the Diagnosis, Staging and Follow-Up of Oncological Diseases
edited by Matteo Bonatti
submission deadline 15 Feb 2025 | Viewed by 206 | Submission Open
Keywords: MRI; cancer; oncology; diagnosis; staging; follow-up; radiomics
(This special issue belongs to the Section Nuclear Medicine & Radiology)
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