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Life
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Eye Diseases: Diagnosis and Treatment, 3rd Edition
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Eye Diseases: Diagnosis and Treatment, 3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1925

Special Issue Editors

Dr. Alba Martín-Gil

E-Mail Website
Guest Editor
Faculty of Optics and Optometry, Ocupharm Group Research, Complutense University, 28037 Madrid, Spain
Interests: nucleotides; purinergic signaling; melatonin; glaucoma; dry eye; contact lenses
Special Issues, Collections and Topics in MDPI journals
Dr. Laura De Diego-García

E-Mail Website
Guest Editor
Faculty of Optics and Optometry, Ocupharm Group Research, Complutense University, 28037 Madrid, Spain
Interests: purinergic signaling; molecular mechanism of disease; central nervous system; neuroinflammation and neurodegeneration; glaucoma; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are grateful to the researchers who contributed to the first and second volumes of this Special Issue:

Eye Diseases: Diagnosis and Treatment: https://www.mdpi.com/journal/life/special_issues/069A11T7EO.

Eye Diseases: Diagnosis and Treatment, 2nd Edition https://www.mdpi.com/journal/life/special_issues/2CSICDW893.

We are pleased to announce the upcoming publication of the third volume of this Special Issue, entitled “Eye Diseases: Diagnosis and Treatment, 3rd Edition".

Eye health is essential in day-to-day life. Ocular retinal pathologies such as glaucoma, age-related macular degeneration, and diabetic retinopathy are the foremost causes of irreversible blindness in developed countries. At the same time, we can find other common ocular diseases, such as keratoconus, dry eye, cataract, or microbial keratitis, which do not cause blindness but substantially impact a patient’s quality of life. The management and treatment of these pathologies have become a worldwide public health burden.

The main goal of the present Special Issue is to highlight both innovative therapeutic approaches and the search for new techniques for the diagnosis of ocular diseases. These findings will provide an overview of the impact of each ocular pathology, not only in humans but also in the eye care system, and could include potential strategies in future therapeutics. We expect to receive both original research and review articles with a focus on (a) new developments in ocular disease diagnosis techniques and (b) new approaches in ocular diseases treatments.

Dr. Alba Martín-Gil
Dr. Laura De Diego-García
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ocular treatment
  • ocular diseases
  • retina
  • anterior eye
  • posterior eye
  • ocular biomarkers

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Published Papers (3 papers)

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Research

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13 pages, 2145 KiB  
Article
Effect of Metformin on Meibomian Gland Epithelial Cells: Implications in Aging and Diabetic Dry Eye Disease
by Leon Rescher, Swati Singh, Ingrid Zahn, Friedrich Paulsen and Martin Schicht
Life 2024, 14(12), 1682; https://doi.org/10.3390/life14121682 - 18 Dec 2024
Viewed by 762
Abstract
Background: Metformin, a commonly prescribed medication for managing diabetes, has garnered increasing interest as a potential therapeutic option for combating cancer and aging. Methods: The current study investigated the effects of metformin treatment on human meibomian gland epithelial cells (hMGECs) at morphological, molecular, [...] Read more.
Background: Metformin, a commonly prescribed medication for managing diabetes, has garnered increasing interest as a potential therapeutic option for combating cancer and aging. Methods: The current study investigated the effects of metformin treatment on human meibomian gland epithelial cells (hMGECs) at morphological, molecular, and electron microscopy levels. HMGECs were stimulated in vitro with 1 mM, 5 mM, and 10 mM metformin for 24, 48, and 72 h. The assessed outcomes were cell proliferation assays, lipid production, ultrastructural changes, levels of IGF-1, Nrf2, HO-1, apoptosis-inducing factor 1 (AIF1) at the protein level, and the expression of oxidative stress factors (matrix metallopeptidase 9, activating transcription factor 3, CYBB, or NADPH oxidase 2, xanthine dehydrogenase). Results: Morphological studies showed increased lipid production, the differentiation of hMGECs after stimulation with metformin, and the differentiation effects of undifferentiated hMGECs. Proliferation tests showed a reduction in cell proliferation with increasing concentrations over time. AIF1 apoptosis levels were not significantly regulated, but morphologically, the dying cells at a higher concentration of 5-10 mM showed a rupture and permeabilization of the plasma membrane, a swelling of the cytoplasm, and vacuolization after more than 48 h. The IGF-1 ELISA showed an irregular expression, which mostly decreased over time. Only at 72 h and 10 mM did we have a significant increase. Mitochondrial metabolic markers such as Nrf2 significantly increased over time, while HO-1 decreased partially. The RT-PCR showed a significant increase in MMP9, CYBB, XDH, and ATF with increasing time and metformin concentrations, indicating cell stress. Conclusions: Our results using a cell line suggest that metformin affects the cellular physiology of meibomian gland epithelial cells and induces cell stress in a dose- and duration-dependent manner, causing changes in their morphology and ultrastructure. Full article
(This article belongs to the Special Issue Eye Diseases: Diagnosis and Treatment, 3rd Edition)
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Review

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12 pages, 250 KiB  
Review
The Seasonality of Retinal Detachment: Peaks, Troughs, and Global Trends
by Georgios N. Tsiropoulos, Efstratia Amaxilati, Marianna Tranou, Eleni P. Papadopoulou, Iordanis Vagiakis, Fotis Topouzis and Georgios D. Panos
Life 2025, 15(2), 190; https://doi.org/10.3390/life15020190 - 27 Jan 2025
Viewed by 427
Abstract
Purpose: To examine the seasonality of retinal detachment (RD) and explore global patterns and contributing factors through a narrative review. Methods: Studies investigating seasonal trends in RD incidence across diverse regions were analysed for peak seasons, meteorological influences, and behavioural factors. Results: RD [...] Read more.
Purpose: To examine the seasonality of retinal detachment (RD) and explore global patterns and contributing factors through a narrative review. Methods: Studies investigating seasonal trends in RD incidence across diverse regions were analysed for peak seasons, meteorological influences, and behavioural factors. Results: RD seasonality varies by region. Northern climates (e.g., Finland) report summer peaks linked to prolonged daylight, while warmer climates (e.g., Kuwait) show winter peaks associated with outdoor activity. Some studies found correlations with temperature, light, and atmospheric pressure, while others reported no seasonal variation. Conclusions: RD seasonality reflects a complex interplay of environmental and behavioural factors. Future research should focus on standardised methodologies to clarify these relationships and inform preventative strategies. Full article
(This article belongs to the Special Issue Eye Diseases: Diagnosis and Treatment, 3rd Edition)

Other

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13 pages, 1868 KiB  
Case Report
Postpartum Exudation of Idiopathic Quiescent Macular Neovascularization: A Narrative Review with a Related Case Report
by Livio Vitiello, Maddalena De Bernardo, Ilaria De Pascale, Giulio Salerno, Alfonso Pellegrino and Nicola Rosa
Life 2025, 15(1), 31; https://doi.org/10.3390/life15010031 - 30 Dec 2024
Viewed by 487
Abstract
The abnormal growth of irregular new blood vessels into the subretinal or intraretinal space is known as macular neovascularization (MNV). People over 50 are often affected by this disorder, which is typically brought on by age-related macular degeneration. In addition, MNV can be [...] Read more.
The abnormal growth of irregular new blood vessels into the subretinal or intraretinal space is known as macular neovascularization (MNV). People over 50 are often affected by this disorder, which is typically brought on by age-related macular degeneration. In addition, MNV can be found in people under 50 years of age, who may present primary ophthalmic diseases such as pathological myopia, angioid streaks, traumatic choroidal rupture, or suspected ocular histoplasmosis syndrome. However, it is important to consider a specific set of young individuals who may develop MNV even in the absence of pathological myopia or other identifiable inflammatory, peripapillary, post-traumatic, or degenerative fundus abnormalities. This latter condition is classified as idiopathic MNV. After a literature review focused on young patients affected by one of these two clinical entities, we report the case of a Caucasian young woman suffering for four years from an idiopathic and quiescent MNV that started exuding after childbirth, probably due to the induction with oxytocin, and was treated with intravitreal Aflibercept 2 mg injections. Full article
(This article belongs to the Special Issue Eye Diseases: Diagnosis and Treatment, 3rd Edition)
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