New Molecules and Mechanisms to Fight the Onset and Progression Cardiovascular Diseases—the Role of Oxidative Stress
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: closed (26 March 2021) | Viewed by 39610
Special Issue Editor
Interests: blood vessels; cerebrovascular disorders; cardiovascular disorders; endothelial function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular diseases are a growing, worldwide epidemic with an enormous economic burden; as such, the care and prevention of cardiovascular alterations constitute an important world challenge. Reduced endothelial function is an early, subclinical stage of vascular alteration that precedes and accompanies the development of cardiovascular diseases, contributing to vascular complications. Downregulated nitric oxide, caused by either reduced synthesis or inactivation due to increased oxidative stress, significantly contributes to endothelial dysfunction. Although many drugs are effective, their molecular mechanisms and long-term side effects are still unknown and are currently an area of active research. Nowadays, biological markers of oxidative stress-induced endothelial injury lack specificity in predicting disease progression in hypertensive patients. On the other hand, clinical trials of antioxidant treatments have failed to show long-term improvements, suggesting the importance of directly acting on upstream signaling to prevent vascular oxidative stress rather than adopting strategies to scavenge reactive oxygen species.
Based on these data, we invite investigators to contribute original research and review articles addressing the identification of novel molecules able to exert beneficial effects on the cardiovascular system, as well as novel roles for old pharmacological molecules.
This will improve our knowledge of possible therapeutic approaches and will open a new scenario to improve the health of patients fighting cardiovascular diseases.
Dr. Albino Carrizzo
Guest Editor
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Keywords
- Identification of novel molecules involved in the onset and progression of cardiovascular diseases
- Novel potential therapeutic approaches to reducing oxidative stress and vascular injury
- Discovery of novel pharmacological approaches to fighting cardiovascular disease
- Identification of novel molecules able to contribute to the reduction of vascular dysfunction
- Identification of novel natural compounds with beneficial cardiovascular properties
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