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Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Comprehensive Treatment and Precision Medicine Strategies for Heart Disease

edited by Serge Sicouri

submission deadline 30 Jun 2026 | 1 articles | Viewed by 902 | Submission Open

Keywords: precision medicine; artificial intelligence; risk stratification; machine learning; translational research; cardiovascular outcomes

(This special issue belongs to the Section Medical Research)

Sleep-Disordered Breathing: Key Pathophysiological Mechanisms and Their Clinical Implications

edited by

Jinkwan Kim

submission deadline 30 Jun 2026 | 1 articles | Viewed by 768 | Submission Open

Keywords: sleep-disordered breathing; sleep fragmentation; inflammation; cardiovascular disease; insulin resistance

(This special issue belongs to the Section Physiology and Pathology)

Extracellular Vesicles: Biology, Mechanisms, and Therapies for Cerebrovascular Disorders

edited by Jinju Wang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 570 | Submission Open

Keywords: extracellular vesicles; cerebrovascular disorders; dementia; extracellular vesicle-based therapy

(This special issue belongs to the Section Physiology and Pathology)

Autoimmune Disorders: From Pathophysiology to Therapeutics

edited by

Giulia Lanzolla

and Chiara Mura

submission deadline 30 Jun 2026 | Viewed by 463 | Submission Open

Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes

(This special issue belongs to the Section Physiology and Pathology)

“Out-of-the-Organics-Box” Reflections On and Scenarios for Life’s Emergence

edited by

Wolfgang Nitschke

submission deadline 30 Jun 2026 | Viewed by 330 | Submission Open

Keywords: emergence of life; thermodynamics; bioenergetics; information theory; early metabolism; metal ions in biochemistry

(This special issue belongs to the Section Origin of Life)

Placental Spectrum Disorders and Gynecological Oncology

edited by Gianluca Raffaello Damiani

submission deadline 30 Jun 2026 | Viewed by 273 | Submission Open

Keywords: placenta; trophoblastic tumor; mola; tumors; bleeding

(This special issue belongs to the Section Medical Research)

Advances in Bioorganic and Medicinal Chemistry

edited by Sahar Kandil

submission deadline 30 Jun 2026 | Viewed by 258 | Submission Open

Keywords: medicinal chemistry; drug discovery; biological chemistry; therapeutic targets; therapeutic agents; treatment of diseases; new therapeutic strategies

Mechanisms and Modulation of Pain: From Ion Channels to Translational Therapeutics

edited by Álvaro Yogi

submission deadline 30 Jun 2026 | Viewed by 230 | Submission Open

Keywords: pain; mechanisms; signaling pathways; ion channels; therapeutic targets; neuropathic pain; inflammatory pain; pre-clinical models

(This special issue belongs to the Section Pharmaceutical Science)

Neural Mechanisms of Brain–Computer Interfaces

edited by

Miguel Pais-Vieira

submission deadline 30 Jun 2026 | Viewed by 230 | Submission Open

Keywords: brain– machine interfaces; neurophysiology; somatosensory cortex; motor cortex

(This special issue belongs to the Section Physiology and Pathology)

Drug Safety and Outcomes in Respiratory and Critical Care Medicine

edited by

Josef Yayan

submission deadline 30 Jun 2026 | Viewed by 225 | Submission Open

Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug– drug interactions

(This special issue belongs to the Section Pharmaceutical Science)

Neurodegeneration Across Mechanisms, Epidemiology, and Emerging Therapies: Inflammation, Metabolism, Aging, and Neuromodulation

edited by Julian Benito Leon

submission deadline 30 Jun 2026 | Viewed by 198 | Submission Open

Keywords: neurodegeneration; neuroinflammation; metabolic dysfunction; aging and inflammaging; epidemiology; biomarkers; neuromodulation; transcranial magnetic stimulation (TMS)

(This special issue belongs to the Section Medical Research)

Rewiring Bacterial Communication: Extracellular Vesicles and Microbial Signals Across Host Interfaces

edited by Sara Carloni

submission deadline 30 Jun 2026 | Viewed by 143 | Submission Open

Keywords: bacterial extracellular vesicles (bEVs); host– microbe communication; microbiota dynamics; immune modulation; translational applications

(This special issue belongs to the Section Microbiology)

Cancer Genomics and Transcriptomics: Uncovering New Frontiers in Tumor Biology

edited by

Panagiotis Adamopoulos

and Panagiotis Tsiakanikas

submission deadline 14 Jul 2026 | 2 articles | Viewed by 1688 | Submission Open

Keywords: transcriptomic profiling; tumor heterogeneity; integrative omics; non-coding RNAs; oncogenes

(This special issue belongs to the Section Genetics and Genomics)

Antimicrobial Innovations

edited by

Pere Puigbò

and Miho Nakamura

submission deadline 15 Jul 2026 | 3 articles | Viewed by 6213 | Submission Open

Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety

(This special issue belongs to the Section Microbiology)

Aspects of the Biology of Populations in Northern Africa and the Middle East

edited by

Kanya Godde

and Shomarka Keita

submission deadline 15 Jul 2026 | Viewed by 513 | Submission Open

Keywords: biodiversity in the Middle East; biodiversity in Northern Africa; population genetics in the Middle East; ecology in the Middle East; ecology in Northern Africa; skeletal variation in the Middle East; skeletal variation in Northern Africa; dental variation in the Middle East; dental variation in Northern Africa

Regulation of Cerebrovascular Resistance in Health and Disease: From Molecules to Humans

edited by

Akos Koller

submission deadline 17 Jul 2026 | 7 articles | Viewed by 20370 | Submission Open

Keywords: cerebral blood flow; hemodynamic forces; cerebrovascular resistance; endothelium; smooth muscle; arachidonic acid metabolites; reactive oxygen species; molecular mediators; protein and mRNA expressions; brain disease conditions; transcranial Doppler measurement; EEG; lifestyle

(This special issue belongs to the Section Physiology and Pathology)

Innovations in Dairy Cattle Health and Nutrition Management

edited by

Rasa Želvytė

and Ingrida Monkevičienė

submission deadline 18 Jul 2026 | 5 articles | Viewed by 7244 | Submission Open

Keywords: innovations; dairy cattle; health; nutrition; rumen; metabolism; biomarkers

(This special issue belongs to the Section Animal Science)

Minimally Invasive and Transcatheter Interventions in Valvular Heart Disease

edited by Adam R. Kowalówka

submission deadline 18 Jul 2026 | 3 articles | Viewed by 1581 | Submission Open

Keywords: transcatheter aortic valve replacement; minimally invasive cardiac surgery; aortic valve interventions; structural heart disease; valve repair outcomes

(This special issue belongs to the Section Medical Research)

Geriatric Health: Integrating Metabolism, Physical Function, and Prevention

edited by

Gwonmin Kim

and

Up Huh

submission deadline 18 Jul 2026 | 2 articles | Viewed by 1408 | Submission Open

Keywords: geriatric health; sarcopenia and frailty; digital health care; age-related diseases; functional decline

(This special issue belongs to the Section Medical Research)

Advances in Ubiquitous Connective Tissue Architecture: Fascia, Dynamic movements and Perception in Living Structures

edited by

Jean Claude Guimberteau

submission deadline 20 Jul 2026 | 3 articles | Viewed by 16220 | Submission Open

Keywords: fascia; connective tissue; fibrillar network; microvolumes; collagen; cell microenvironment; force absorption system

(This special issue belongs to the Section Cell Biology and Tissue Engineering)

New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases

edited by

Cristina Marginean

submission deadline 20 Jul 2026 | 5 articles | Viewed by 13973 | Submission Open

Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs

(This special issue belongs to the Section Medical Research)

Herbal Extracts in Skin Health and Disease

edited by

Josipa Bukić

submission deadline 20 Jul 2026 | Viewed by 345 | Submission Open

Keywords: herbal extracts; natural products; skin disorders; skin care

(This special issue belongs to the Section Pharmaceutical Science)

Emerging Knowledge on Human Immunodeficiency Virus

edited by

Giota Lourida

and

Dimitrios Paraskevis

submission deadline 22 Jul 2026 | 3 articles | Viewed by 31059 | Submission Open

Keywords: HIV; antiretroviral treatment; long-acting ART; pre-exposure prophylaxis; HIV surveillance; antiretroviral resistance; primary resistance; HIV epidemiology; special populations; cascade of care; HIV diagnosis

(This special issue belongs to the Section Medical Research)

Language Models in Lab Coats: AI-Powered Biomedical Interpretation

edited by Sebastian Sanduleanu

submission deadline 23 Jul 2026 | 1 articles | Viewed by 2378 | Submission Open

Keywords: radiology; large language models; artificial intelligence; radiobiology

(This special issue belongs to the Section Medical Research)

Genetics, Breeding, and Reproduction of Cattle

edited by

Hailiang Zhang

and

Shanjiang Zhao

submission deadline 24 Jul 2026 | Viewed by 409 | Submission Open

Keywords: cattle; genetic selection; reproductive physiology and technology

(This special issue belongs to the Section Animal Science)

Contemporary Therapeutic Strategies for Solid Tumors

edited by Chohao Lee

submission deadline 26 Jul 2026 | 4 articles | Viewed by 2957 | Submission Open

Keywords: therapeutic strategies; survival analysis; solid tumors; cancer treatment; targeted therapy; immunotherapy; precision medicine; clinical outcomes; prognostic factors

(This special issue belongs to the Section Medical Research)

Advanced Research in Obstetrics and Gynecology

edited by Vasileios Pergialiotis

submission deadline 28 Jul 2026 | 4 articles | Viewed by 13196 | Submission Open

Keywords: obstetrics; gynecology; gynecologic oncology

(This special issue belongs to the Section Medical Research)

Promising Therapeutic Horizons for Regenerative Medicine in Animals

edited by

Hussein M. El-Husseiny

and

Sharun Khan

submission deadline 28 Jul 2026 | Viewed by 459 | Submission Open

Keywords: stem cells; induced pluripotent stem cells (iPSCs); soft tissue engineering; in vivo and in vitro investigations; extracellular vesicles; preclinical studies; clinical studies; platelet-rich plasma; platelet-rich fibrin; cell-based therapy; cell-free therapy; orthopedics; cardiology

(This special issue belongs to the Section Animal Science)

New Insights into Parkinson’s Disease: From Molecular Basis to Therapy—2nd Edition

edited by

Kallirhoe Kalinderi

submission deadline 28 Jul 2026 | Viewed by 216 | Submission Open

(This special issue belongs to the Section Medical Research)

Prostate Cancer: 4th Edition

edited by

Paula Oliveira

and

Ana Faustino

submission deadline 30 Jul 2026 | 4 articles | Viewed by 7568 | Submission Open

Keywords: incidence; mortality; diagnosis; histopathology; imaging; treatment; prognosis; case report; animals; humans; modeling

(This special issue belongs to the Section Medical Research)

Migraine and Headache: From Pathophysiological Aspects

edited by

Jacob Genizi

submission deadline 30 Jul 2026 | 3 articles | Viewed by 5795 | Submission Open

Keywords: migraine; headache; pathophysiology; treatment; medication

(This special issue belongs to the Section Physiology and Pathology)

Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy

edited by Przemysław Kosinski

submission deadline 30 Jul 2026 | 4 articles | Viewed by 5371 | Submission Open

Keywords: fetal medicine; prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal therapy; fetal surgery; neonatal intensive care; genetic and genomic advances; perinatal outcomes; maternal-fetal health

(This special issue belongs to the Section Reproductive and Developmental Biology)

Recent Advances in Bone Biology

edited by Barbara Peruzzi,

Martina Leopizzi

and Giulia Battafarano

submission deadline 30 Jul 2026 | 2 articles | Viewed by 2913 | Submission Open

Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism

(This special issue belongs to the Section Physiology and Pathology)

Therapeutic Effects of Natural Products on Human Diseases—3rd Edition

edited by

Seung Ho Lee

submission deadline 30 Jul 2026 | 3 articles | Viewed by 2741 | Submission Open

Keywords: natural products; natural extracts; cancer; neurodegenerative diseases; immunological disorders; metabolic diseases; oriental medicine; microorganisms; algae; functional foods

(This special issue belongs to the Section Pharmaceutical Science)

Treatment and Prognosis of Thoracic Diseases

edited by

Alessandro Gonfiotti

and

Alice Ravasin

submission deadline 30 Jul 2026 | 1 articles | Viewed by 1669 | Submission Open

Keywords: thoracic malignancies; lung cancer management ; targeted therapy ; immunotherapy ; molecular diagnostics ; multidisciplinary care ; personalized treatment

(This special issue belongs to the Section Medical Research)

Migraine and Headache: From Clinical and Therapeutic Aspects

edited by

Jacob Genizi

submission deadline 30 Jul 2026 | Viewed by 363 | Submission Open

Keywords: migraine; headache; treatment; medication

(This special issue belongs to the Section Medical Research)

Advances and Applications of Sport Physiology: 2nd Edition

edited by

Sime Versic

and

Nikola Foretic

submission deadline 31 Jul 2026 | 9 articles | Viewed by 15312 | Submission Open

Keywords: sports medicine; strength and conditioning; diagnostics; sport injuries; performance analysis

(This special issue belongs to the Section Physiology and Pathology)

Human Infertility and Reproductive Endocrinology: 2nd Edition

edited by

Giuseppe Grande

submission deadline 31 Jul 2026 | 5 articles | Viewed by 10850 | Submission Open

Keywords: infertility; reproduction; reproductive endocrinology; male infertility; female infertility

(This special issue belongs to the Section Reproductive and Developmental Biology)

Sports Biomechanics, Injury, and Physiotherapy

edited by Manos Stefanakis

submission deadline 31 Jul 2026 | 6 articles | Viewed by 5252 | Submission Open

Keywords: sports injuries; epidemiology; data-driven rehabilitation; objective assessment; injury prevention; return to play

(This special issue belongs to the Section Physiology and Pathology)

Precision Medicine in Heart Failure: From Biomarkers to Targeted Therapies

edited by

Cristian Mornoş

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3059 | Submission Open

Keywords: heart failure; precision medicine; biomarkers; multi-omics; personalized therapy; cardiovascular imaging; genetic profiling; artificial intelligence; risk stratification; targeted therapies

(This special issue belongs to the Section Medical Research)

Multimodal AI for Genomic-Clinicopathologic Integration: From Preventive Screening to Precision Diagnosis

edited by Yen-Lin Chen

submission deadline 31 Jul 2026 | 3 articles | Viewed by 2213 | Submission Open

Keywords: multimodal data integration; artificial intelligence in medicine; genomic and health data analysis; digital pathology and image analysis; predictive modeling and risk stratification; explainable machine learning (XAI)

(This special issue belongs to the Section Biochemistry, Biophysics and Computational Biology)

Microorganisms Engineering and Gene-Editing Methods

edited by

Jichao Wang

Guang Zhao

and Xia Zhao

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2102 | Submission Open

Keywords: microorganisms engineering; metabolic engineering; strain optimization; gene editing; CRISPR; recombination

(This special issue belongs to the Section Genetics and Genomics)

New Insights into Pneumonia Pathophysiology—from Lung Fibrosis to Coagulation Disorders

edited by Mihai Lazar

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2084 | Submission Open

Keywords: pneumonia pathophysiology; lung fibrosis; coagulation disorders; thromboinflammation; immune dysregulation; diagnostic biomarkers; translational medicine

(This special issue belongs to the Section Physiology and Pathology)

Innovation in Fish Nutrition, Production Technology, and Welfare

edited by

Marian Burducea

, Liviu-Dan Miron and

Cristian-Alin Barbacariu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1722 | Submission Open

Keywords: aquaculture; fish nutrition; fish welfare; water quality; fish disease; feed additives; rearing systems; modern feeding technologies; waste management

Chemical Evolutionary Pathways to Origins of Life

edited by

Claudia Huber

and Christian Seitz

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1595 | Submission Open

Keywords: origin of life; metabolism-first; early Earth; iron– sulfur world; chemical evolution ; cellularization; surface catalysis; pioneer organism

(This special issue belongs to the Section Origin of Life)

Vetinformatics-Driven Approaches to Animal Health and Disease

edited by

Jun-Mo Kim

and

Rajesh Kumar Pathak

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1587 | Submission Open

Keywords: animal health; livestock disease; vetinformatics; computational genomics; RNAseq; multi-omics; drug discovery; molecular docking; molecular dynamics simulation; vaccine design; one health

(This special issue belongs to the Section Animal Science)

Mechanisms and Treatment of Eye and Vision Conditions

edited by Jeong-Min Hwang

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1367 | Submission Open

Keywords: mechanism; treatment; eye; vision

(This special issue belongs to the Section Medical Research)

Non-Conventional Approaches in Modern Biological Analysis and Medical Diagnostics

edited by

Anna Baraniak

and

Paweł Rudnicki-Velasquez

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1186 | Submission Open

Keywords: biological samples; non-conventional analytical techniques; life science; diagnostics; proteins

Skin Care and Innovation from the Perspective of Molecular Dermatology

edited by

Ewa Markiewicz

Olusola Idowu

and

Jacek C. Szepietowski

submission deadline 31 Jul 2026 | 1 articles | Viewed by 925 | Submission Open

Keywords: molecular dermatology; personalised skincare; ageing; natural ingredients

(This special issue belongs to the Section Physiology and Pathology)

Metabolic Research in Animal Nutrition

edited by

Sylwia Szymańczyk

Marek Bienko

and

Radosław P. Radzki

submission deadline 31 Jul 2026 | Viewed by 826 | Submission Open

Keywords: nutrition; supplementation; microbiota; obesity; metabolic syndrome; metabolic disorders and diseases; hormonal factors; development and metabolism; metabolomics; nutrigenomics

(This special issue belongs to the Section Animal Science)

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