Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Progress in Rehabilitation Interventions for Heart Failure
edited by , Jhonatan Betancourt-Peña, Iago Portela and Mauricio Hernández-Carrillo
submission deadline 31 Aug 2026 | Viewed by 207 | Submission Open
Keywords: heart failure; rehabilitation; exercise; interdisciplinary; telerehabilitation
(This special issue belongs to the Section Medical Research)
Molecular Regulation of Fruit Development in Solanaceous Crops: From Genes to Phenotypes
edited by , Wencai Yang and Ruohe Yin
submission deadline 31 Aug 2026 | Viewed by 198 | Submission Open
Keywords: Solanaceous crops; fruit development; omics; genetics; phenotype
(This special issue belongs to the Section Plant Science)
Molecular Pathways Shaping Head and Neck Cancer Care submission deadline 31 Aug 2026 | Viewed by 197 | Submission Open
Keywords: head and neck cancer; molecular pathways; tumor microenvironment; precision oncology; translational research
(This special issue belongs to the Section Medical Research)
Protein Structure and Engineering: From Folding Cages to Functional Assemblies submission deadline 31 Aug 2026 | Viewed by 188 | Submission Open
Keywords: protein structure; self-assembly; functional assemblies; protein engineering; protein– protein interaction; biomaterials; building blocks; biotechnological applications
(This special issue belongs to the Section Proteins and Proteomics)
Translational Advances in Postoperative Pain: From Mechanisms to Clinical Application
edited by and Boya Liao
submission deadline 31 Aug 2026 | Viewed by 187 | Submission Open
Keywords: postoperative pain; perioperative medicine; chronic postsurgical pain; multimodal analgesia; neu-romodulation; inflammation and pain; opioid sparing strategies; translational pain research; chronic postsurgical pain; persistent opioid use
(This special issue belongs to the Section Medical Research)
The Biochemistry of Venoms: Exploring Molecular Diversity, Structural Mechanisms, and Their Biotechnological Uses
edited by and Ludovico Migliolo
submission deadline 31 Aug 2026 | Viewed by 185 | Submission Open
Keywords: biochemistry of venoms; venomics; diversity of toxins; mechanism of action; bioprospecting
(This special issue belongs to the Section Pharmaceutical Science)
A Paradigm Shift in Airway and Pain Management—3rd Edition
edited by
submission deadline 31 Aug 2026 | Viewed by 179 | Submission Open
Keywords: airway management; difficult airway; video intubating stylet; pain management; ultrasonography; motor-sparing strategies; nerve block; regenerative medicine; transarterial embolization for pain management; joint denervation for pain management; rTMS (repetitive transcranial magnetic stimulation); central post-stroke pain; neuromodulation
(This special issue belongs to the Section Medical Research)
Management of Inflammatory Airway Diseases submission deadline 31 Aug 2026 | Viewed by 178 | Submission Open
Keywords: inflammatory airway diseases; asthma; EGPA; COPD; chronic rhinosinusitis; biomarkers; biologics; treatable traits; precision medicine
(This special issue belongs to the Section Medical Research)
Innovations in the Diagnosis and Treatment of Inflammatory Bowel Disease
edited by Aldona Wierzbicka-Rucinska
submission deadline 31 Aug 2026 | Viewed by 172 | Submission Open
Keywords: inflammatory bowel disease (IBD); molecular and imaging diagnostics; personalized treatment approaches; precision medicine; pharmacological and biologic therapies; pathophysiology
(This special issue belongs to the Section Medical Research)
Myeloproliferative Neoplasms: From Biology to Practice
edited by Adrian Duek
submission deadline 31 Aug 2026 | Viewed by 155 | Submission Open
Keywords: polycythemia vera; essential thrombocythemia; primary myelofibrosis; JAK2 V617F; calreticulin; MPL; next-generation sequencing; risk factor scores
(This special issue belongs to the Section Medical Research)
Diagnosis, Treatment and Prognosis of Head and Neck Disorders
edited by
submission deadline 31 Aug 2026 | Viewed by 151 | Submission Open
Keywords: head and neck disorders  ; head and neck cancer  ; otolaryngology  ; diagnostic imaging and endoscopy  ; targeted therapy and immunotherapy  ; biomarkers and molecular pathology  ; precision medicine  ; prognostic models and outcomes  ; translational research
(This special issue belongs to the Section Medical Research)
Nutritional Value and Stress Tolerance Mechanisms in Legume Crops
edited by Carlos Pimentel
submission deadline 31 Aug 2026 | Viewed by 136 | Submission Open
Keywords: water stress; temperature; salinity; heavy metals; stress adaptation; biological nitrogen fixation; grain quality; yield
(This special issue belongs to the Section Plant Science)
Novel Insights into Stress and Nutritional Regulation in Animals
edited by Hao-Yang Sun, , Zhan-Wei Teng and Xiao Liu
submission deadline 1 Sep 2026 | Viewed by 237 | Submission Open
Keywords: stress; nutrition; resilience; gut– X axis; microbiome; precision nutrition; multi-omics
(This special issue belongs to the Section Animal Science)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases: 2nd Edition
edited by
submission deadline 1 Sep 2026 | Viewed by 135 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
Obstetrics and Gynecology Medicine: From Bench to Bedside—3rd Edition submission deadline 15 Sep 2026 | 2 articles | Viewed by 805 | Submission Open
Keywords: obstetrics; gynecology; translational research; translational medicine
(This special issue belongs to the Section Medical Research)
Plants: Emerging Bio-Manufacturing Chassis for Bioactive Molecules
edited by
submission deadline 15 Sep 2026 | Viewed by 195 | Submission Open
Keywords: plant biotechnology; metabolic engineering; secondary metabolite; recombinant proteins; synthetic biology; biopharmaceuticals; plant cell culture; molecular farming
(This special issue belongs to the Section Plant Science)
Sleep-Disordered Breathing: Cardiovascular Vulnerability
edited by Ravi S. Aysola
submission deadline 15 Sep 2026 | Viewed by 101 | Submission Open
Keywords: sleep-disordered breathing; obstructive sleep apnea; cardiovascular disease; autonomic nervous system; ventilatory control; intermittent hypoxia; cardiopulmonary coupling; hypertension
(This special issue belongs to the Section Medical Research)
Bioactive Natural Products: From Exploration to Therapeutic Potential submission deadline 16 Sep 2026 | 1 articles | Viewed by 1219 | Submission Open
Keywords: secondary metabolites; in vivo/in vitro biological activity; structural elucidation; molecular modeling studies; natural pigment
(This special issue belongs to the Section Pharmaceutical Science)
Immune Reset and Renal Recovery: Novel Insights into Kidney Inflammation and Repair
edited by Mohanraj Sadasivam
submission deadline 17 Sep 2026 | Viewed by 490 | Submission Open
Keywords: renal immunopathology; immune reset; CAR-T-cell therapy; B-cell depletion; mRNA therapies; autoimmune kidney disease; lupus nephritis; T-cell tolerance; kidney inflammation; renal regeneration
(This special issue belongs to the Section Medical Research)
Advances in 5-Aminolevulinic Acid Applications in Medical and Healthcare
edited by Motowo Nakajima, Walter Stummer and Shun-ichiro Ogura
submission deadline 18 Sep 2026 | 9 articles | Viewed by 16382 | Submission Open
Keywords: 5-aminolevulinic acid (5-ALA); heme; protoporphyrin IX; photodynamic diagnosis; fluorescence guided surgery; photodynamic therapy; cancer metastasis; reactive oxygen species (ROS); oxide radical; heme oxygenase 1 (HO-1); NF-E2-related factor 2 (Nrf2); anti-inflammation; mitochondrial disease; diabetes; infectious disease; malaria; COVID-19
(This special issue belongs to the Section Pharmaceutical Science)
Gastrointestinal Health: Clinical Research and Therapeutic Innovations—2nd Edition submission deadline 18 Sep 2026 | 5 articles | Viewed by 2876 | Submission Open
Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence
(This special issue belongs to the Section Medical Research)
Gynecology Update: Modern Diagnostic Approaches and Innovative Therapies
edited by Szabolcs Várbíró, , Richárd Tóth and Balázs Lintner
submission deadline 20 Sep 2026 | 5 articles | Viewed by 6503 | Submission Open
Keywords: gynecologic oncology; endocrinology; reproductive medicine; fertility preservation; prevention; women’ s health innovation; quality of life; personalized therapy
(This special issue belongs to the Section Medical Research)
Prebiotic RNA: From Autocatalysis and Chirality to Functional Evolution
edited by
submission deadline 20 Sep 2026 | Viewed by 525 | Submission Open
Keywords: RNA; origin of life; replication; autocatalysis; chirality; ribozymes; metabolism
(This special issue belongs to the Section Origin of Life)
Translational Neuro-Oncology: Molecular Insights, Bioinformatics, and Technological Innovations
edited by Felix Mircea Brehar
submission deadline 20 Sep 2026 | Viewed by 303 | Submission Open
Keywords: translational neuro-oncology; central nervous system tumors; molecular and cellular mechanisms; multi-omics and biomarkers; bioinformatics and systems biology; artificial intelligence in medicine; radiomics and radiogenomics; precision neurosurgery; experimental and clinical research; therapeutic innovation in neuro-oncology
(This special issue belongs to the Section Physiology and Pathology)
Mucosal Immunity and Immune Memory: The New Frontier in Vaccination and Immunopathology
edited by
submission deadline 20 Sep 2026 | Viewed by 260 | Submission Open
Keywords: mucosal immunity; hybrid immunity; next-generation vaccines; artificial intelligence; neo-adjuvants; clinical trial; case studies
(This special issue belongs to the Section Medical Research)
Imaging and Analysis of Microbial Motility: From Single Cells to Communities
edited by
submission deadline 20 Sep 2026 | Viewed by 176 | Submission Open
Keywords: motility; cell tracking; biofilm; swimming; swarming; Archaea; flagella
(This special issue belongs to the Section Microbiology)
Microbiome Engineering for Sustainable Pest Control Under Climate Change
edited by Abdul Basit and
submission deadline 20 Sep 2026 | Viewed by 160 | Submission Open
Keywords: microbiome engineering; climate-smart pest management; systems biology; One Health; sustainable agriculture; microbial ecology; plant resilience; climate change; beneficial microbes; evolutionary biology; environmental sustainability; agricultural ecosystems; microbial communities
(This special issue belongs to the Section Microbiology)
Liver Disease: Pathogenesis, Diagnosis, and Treatments
edited by Hsien-Hui Chung
submission deadline 25 Sep 2026 | 4 articles | Viewed by 6802 | Submission Open
Keywords: alcoholic hepatitis; artificial intelligence; biomarkers; clinical trials; gut– liver axis; liver cancer; metabolic dysfunction-associated steatohepatitis; molecular targets; pharmacotherapeutic mechanisms; therapeutic strategies
(This special issue belongs to the Section Medical Research)
Plant Life: Integrating Multi-Omic Approaches from Molecules to Environment
edited by and Fang He
submission deadline 25 Sep 2026 | 4 articles | Viewed by 2193 | Submission Open
Keywords: plant physiology; multi-omics integration; ionomics; genomics; transcriptomics; metabolomics; proteomics; epigenetics; single-cell analysis; environmental stress; molecular mechanisms; systems biology
(This special issue belongs to the Section Plant Science)
Mitochondrial and Endoplasmic Reticulum Dynamics in Cellular Stress Responses
edited by , Xing Duan and
submission deadline 25 Sep 2026 | 1 articles | Viewed by 955 | Submission Open
Keywords: mitochondria; endoplasmic reticulum; MAMs; cellular responses; physiopathology; homeostasis; cross-talk; stress; signaling; regulation
(This special issue belongs to the Section Physiology and Pathology)
Spotlight on Veterinary Pathology and Toxicology
edited by and Mario Darius Codreanu
submission deadline 25 Sep 2026 | 1 articles | Viewed by 612 | Submission Open
Keywords: veterinary pathology; toxicology; advanced diagnostic techniques; pathogenesis; public health
(This special issue belongs to the Section Animal Science)
Pathogenesis and Novel Treatment for Kidney Diseases
edited by
submission deadline 25 Sep 2026 | 1 articles | Viewed by 595 | Submission Open
Keywords: molecular mechanisms of kidney disease; pathophysiology of renal injury; inflammation and fibrosis in kidney disease; novel therapeutic targets; precision medicine in nephrology; translational approaches in renal disease
(This special issue belongs to the Section Medical Research)
From Physiology and Pathology Research to Clinical Insights in Gastrointestinal Disorders
edited by , and Ana Lascu
submission deadline 30 Sep 2026 | 5 articles | Viewed by 18013 | Submission Open
Keywords: cellular signaling; inflammation; oxidative stress; cellular death and proliferation; motility; digestion and absorption; vascular patterns; gut microbiota
(This special issue belongs to the Section Physiology and Pathology)
Advances in Bioprinting, Tissue Engineering, and Regenerative Medicine
edited by
submission deadline 30 Sep 2026 | 4 articles | Viewed by 14565 | Submission Open
Keywords: model tissues; scaffolds; biocompatible materials; biodegradable materials; tissue-on-a-chip; organoids
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Feature Papers in Synthetic Biology and Systems Biology 2026
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 6865 | Submission Open
Keywords: design and construction of synthetic biological systems; innovations in the creation of synthetic organisms; genetic circuits; and biomolecular devices; bottom-up synthetic biology; cell-free synthetic biology; tissue engineering and organoids; bioorthogonal parts; devices; systems; microcompartmentalized systems with soft or hard interfaces; theoretical considerations about synthetic biology; synthetic biology intersection with systems chemistry and bioorganic chemistry; computational modeling and simulation of biological processes; advances in computational tools and models that enhance our understanding of biological processes and systems; metabolic engineering and synthetic pathways; development of novel approaches for the production of biofuels; pharmaceuticals; and other valuable compounds; synthetic biology for approaching evolutionary problems; artificial evolution and in vitro evolution; optogenetics and related techniques; gene editing technologies; applications; and developments; education in synthetic and systems biology; cutting-edge techniques and applications of CRISPR and other gene editing tools; systems biology approaches to understanding complex biological networks; mathematical aspects of systems biology approaches; artificial photosynthesis; applications of synthetic biology in medicine; agriculture; and industry; practical applications of synthetic and systems biology in various sectors; including healthcare; agriculture; and industrial biotechnology; ethical; legal; and social implications of synthetic and systems biology; exploration of the broader implications of advancements in synthetic and systems biology; including ethical considerations and regulatory challenges and social implications
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Genetics, Breeding and Reproduction of Honeybees: Second Edition
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 6780 | Submission Open
Keywords: phenomics; genetics; genomics; functional genomics; metabolomics; functional genes identification; genetics editing; genome selection; genetic evaluation; hybrid breeding; egg-laying; honey production; queen breeding; varroa resistance
(This special issue belongs to the Section Animal Science)
Natural Products and Modern Drug Discovery: Emerging Strategies Targeting Cancer- and Disease-Related Molecular Mechanisms
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 4489 | Submission Open
Keywords: natural products; phytochemicals; drug discovery; bioactivity profiling; pharmacophore modeling; synthetic biology; cancer therapy; microbial metabolites
(This special issue belongs to the Section Medical Research)
Advances in the Rehabilitation of Stroke
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 4260 | Submission Open
Keywords: stroke; acute stroke; chronic stroke; post-acute stroke; functional recovery; rehabilitation
(This special issue belongs to the Section Medical Research)
Advances in Plant Biotechnology and Molecular Breeding
edited by Serik Eliby, Nikolai Borisjuk and
submission deadline 30 Sep 2026 | 3 articles | Viewed by 4037 | Submission Open
Keywords: doubled haploidy; genetic engineering; genome editing; genomics; marker-assisted selection; molecular breeding; molecular markers; plant biotechnology
(This special issue belongs to the Section Plant Science)
Advances in Personalized Management in Orthopedics and Traumatology submission deadline 30 Sep 2026 | 4 articles | Viewed by 3017 | Submission Open
Keywords: personalized orthopedics; hip replacement; knee replacement; patient-specific treatment; clinical outcomes
(This special issue belongs to the Section Medical Research)
Research Updates in Hematology
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2607 | Submission Open
Keywords: antiphospholipid syndrome; complement; endothelium; hemoglobinopathies; hemophilia; leukemias; lymphomas; multiple myeloma; pediatric hematology; thrombosis
(This special issue belongs to the Section Physiology and Pathology)
Nutrition–Physiology Interactions in Aquatic Species
edited by , and
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2564 | Submission Open
Keywords: aquatic animal nutrition; fish physiology; sustainable aquaculture; alternative lipid sources; alternative protein sources; gut– microbiota interactions
(This special issue belongs to the Section Animal Science)
Prebiotic Chemistry: The Molecular Origins of Life
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 2557 | Submission Open
Keywords: astrobiology; astrochemistry; biochemistry; computational modelling; geochemistry; metabolic pathways; lipid formation; peptide synthesis; photochemistry; radiation chemistry; RNA world; self-assembly; systems chemistry
(This special issue belongs to the Section Origin of Life)
Advances in Imaging for Female Patients: Breast and Gynecological Diagnostics
edited by Silvia Gigli, Emanuele David and Giacomo Bonito
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1739 | Submission Open
Keywords: breast cancer; breast screening; gynecological cancer; mammography; CEM; ultrasound; MRI; PET/TC; radiomics; artificial intelligence
(This special issue belongs to the Section Medical Research)
Pathophysiology, Diagnosis, and Treatments of Intestinal Diseases—2nd Edition
edited by Amosy Ephreim M’Koma
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1695 | Submission Open
Keywords: gastrointestinal disease/disorders; pathophysiology; diagnostics and treatment
(This special issue belongs to the Section Physiology and Pathology)
Ocular Diseases: Mechanisms, Diagnostics, and Emerging Therapeutic Strategies
edited by Joanna Dolar-Szczasny
submission deadline 30 Sep 2026 | 3 articles | Viewed by 1594 | Submission Open
Keywords: molecular mechanisms of eye disease; oxidative stress and inflammation; neurodegeneration in vision; ocular biomarkers; pharmacological therapies; gene therapy; stem cell and regenerative approaches; precision/personalized ophthalmology
(This special issue belongs to the Section Medical Research)
Microbial Biotechnology and Biomanufacturing submission deadline 30 Sep 2026 | 1 articles | Viewed by 1491 | Submission Open
Keywords: synthetic biology tools; microbial biomanufacturing; future foods; bulk chemicals; plant natural products
(This special issue belongs to the Section Synthetic Biology and Systems Biology)
Advanced Research in Plant–Pathogen Interactions
edited by and
submission deadline 30 Sep 2026 | 2 articles | Viewed by 1468 | Submission Open
Keywords: plant-pathogen interaction; plant immunity; pathogen effectors; host defense mechanisms; autophagy; noncoding RNA; small peptides; molecular plant pathology; crop disease resistance
(This special issue belongs to the Section Plant Science)
Microvascular Research: Advances and Perspectives submission deadline 30 Sep 2026 | 2 articles | Viewed by 1395 | Submission Open
Keywords: microvasculature; microvascular dysfunction; systemic diseases; pathophysiology; cardiovascular diseases; hypertension; therapeutic advances
(This special issue belongs to the Section Medical Research)
The Biological Impacts of Fetal Alcohol Exposure
edited by Kelly J. Huffman
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1303 | Submission Open
Keywords: fetal alcohol spectrum disorders; fetal alcohol syndrome; brain development; behavioral development; prenatal exposure
(This special issue belongs to the Section Reproductive and Developmental Biology)
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