Recent Advances in Antimicrobial Treatment in Internal Medicine

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Infectious Disease".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1735

Special Issue Editors


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Guest Editor
AORN Ospedali dei Colli, Department of Infectious Disease and Immunology, Naples, Italy
Interests: infectious disease

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Guest Editor
Ospedale V. Monaldi, Naples, Italy
Interests: internal medicine

Special Issue Information

Dear Colleagues, 

Infections have become more difficult to treat as a result of not appropriate use of antibiotics. With drug resistance, antimicrobial treatment no longer has the desired effect, which increases the risk of poor outcomes in patients with AMR-related infections. Despite a relatively low rate of bacterial coinfection during SARS-COV-2 infection, there was a significant increase in antibiotic prescriptions during the COVID-19 pandemic. Misuse of antibiotics in these patients may increase the selective pressure for antimicrobial resistance (AMR).

The current special issue as the main aim to discuss recent advances in Antimicrobial treatment in Internal medicine. Thus, Reviews, original articles and case reports could be submitted to share experiences and rational use of antibiotics in internal medicine ward unit. Would also be accepted, as submission, also papers on strategic approach to antimicrobial stewardship and infection control throughout a correct use of antibiotics.

Prof. Dr. Alessandro Perrella
Prof. Dr. Ada Maffettone
Guest Editors

Manuscript Submission Information

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Keywords

  • infection control
  • antimicrobial stewardship
  • antibiotics
  • multidrug resistance
  • bacterial
  • antimicrobial resistance

Published Papers (1 paper)

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Review

19 pages, 1251 KiB  
Review
Carbapenem-Resistant Enterobacteriaceae in Urinary Tract Infections: From Biological Insights to Emerging Therapeutic Alternatives
by Eugenio Bologna, Leslie Claire Licari, Celeste Manfredi, Francesco Ditonno, Luigi Cirillo, Giovanni Maria Fusco, Marco Abate, Francesco Passaro, Ernesto Di Mauro, Felice Crocetto, Savio Domenico Pandolfo, Achille Aveta, Simone Cilio, Isabella Di Filippo, Biagio Barone, Antonio Franco, Davide Arcaniolo, Roberto La Rocca, Biagio Pinchera and Luigi Napolitano
Medicina 2024, 60(2), 214; https://doi.org/10.3390/medicina60020214 - 26 Jan 2024
Cited by 1 | Viewed by 1448
Abstract
Urinary tract infections (UTIs) are the second most frequent type of infection observed in clinical practice. Gram-negative Enterobacteriaceae are common pathogens in UTIs. Excessive antibiotic use in humans and animals, poor infection control, and increased global travel have accelerated the spread of multidrug-resistant [...] Read more.
Urinary tract infections (UTIs) are the second most frequent type of infection observed in clinical practice. Gram-negative Enterobacteriaceae are common pathogens in UTIs. Excessive antibiotic use in humans and animals, poor infection control, and increased global travel have accelerated the spread of multidrug-resistant strains (MDR). Carbapenem antibiotics are commonly considered the last line of defense against MDR Gram-negative bacteria; however, their efficacy is now threatened by the increasing prevalence of carbapenem-resistant Enterobacteriaceae (CRE). This comprehensive review aims to explore the biological mechanisms underlying carbapenem resistance and to present a focus on therapeutic alternatives currently available for complicated UTIs (cUTIs). A comprehensive bibliographic search was conducted on the PubMed/MEDLINE, Scopus, and Web of Science databases in December 2023. The best evidence on the topic was selected, described, and discussed. Analyzed with particular interest were the clinical trials pivotal to the introduction of new pharmacological treatments in the management of complicated cUTIs. Additional suitable articles were collected by manually cross-referencing the bibliography of previously selected papers. This overview provides a current and comprehensive examination of the treatment options available for CRE infections, offering a valuable resource for understanding this constantly evolving public health challenge. Full article
(This article belongs to the Special Issue Recent Advances in Antimicrobial Treatment in Internal Medicine)
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