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Medicina
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Importance and Consequences of Nutrition and Diet Plans for the...
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Importance and Consequences of Nutrition and Diet Plans for the Management of Gastrointestinal Disorders

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 11281

Special Issue Editors

Dr. Anil K. Verma

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Guest Editor
Division of Gastroenterology, McMaster University Medical Centre, Hamilton, ON, Canada
Interests: celiac disease; gluten contamination; HLA-DQ distribution; other gluten related disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Yeliz Serin

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Guest Editor
Nutrition and Dietetic Department, Faculty of Health Sciences, Çukurova University, Adana, Turkey
Interests: clinical pediatric nutrition; diet treatment; celiac disease; gastrointestinal disorders; gluten-free diet; food allergy; eating disorder; sports nutrition

Special Issue Information

Dear Colleagues,

Diet and nutrition are significant components in the pathogenesis, treatment, and management of various gastrointestinal disorders. Diarrhea, constipation, and gastrointestinal dysmotility affect the absorption of nutrients in metabolism. Detection and management of malnutrition in patients with the gastrointestinal disease are important and influence patient health outcomes. While a balanced and adequately nutritious diet helps maintain a healthy digestive system. An imbalanced diet, on the other hand, stimulates several digestion-related conditions such as constipation and malnutrition. In some digestive diseases (e.g., celiac disease) a customized recommended diet plan (gluten-free diet) restores the normal intestinal structure and protects patients.

A significant positive impact of a healthy diet plan has been observed in other gastrointestinal disorders like Inflammatory bowel disease, eosinophilic disorders, pancreatic disorders, chronic liver diseases, and intestinal failure. However, the disease-specific role of diet has not been understood but the available evidence supports that food and controlled nutrition can prevent and modulate the disease symptoms. One of the main purposes of nutrition is to prepare the most appropriate diet plan to protect patients from specific disease-related complications during acute or chronic disease state and to provide adequate and balanced nutrition.

It is extremely important to discuss clinical nutrition recommendations from current perspectives, inspiring future studies, as well as developing new evidence-based nutritional recommendations. Many questions concerning the role of nutrition in gastrointestinal disorders are still not fully answered and need further investigations.

In this special issue, we invite articles that are related to nutrition and dietetic approaches in gastrointestinal disorders. This special issue will also cover the Subtopics of interest including (but not limited to):

  • New approaches in the dietetics 
  • Water footprint and carbon footprint of diet in gastrointestinal disorders
  • Psychological effects and management of diets in gastrointestinal disorders
  • The importance of food literacy in diet
  • Current and future tools to measure nutritional deficiencies 
  • Nutritional screening and assessment of gastrointestinal disorder
  • Social pressure and quality of life after adopting a special diet plan
  • The advantages and disadvantages of some dietetic approaches in gastrointestinal disorders
  • Impact of nutrients on different gastrointestinal disorders
  • Diet quality indexes in gastrointestinal disorders
  • Factors affecting diet compliance and sustainability in gastrointestinal disorders.

Dr. Anil K. Verma
Dr. Yeliz Serin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • digestion
  • digestive diseases
  • gastrointestinal disorder
  • malnutrition
  • food
  • nutrition
  • balanced diet
  • diet treatment
  • clinical nutrition
  • nutrition assessment

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

14 pages, 530 KiB  
Article
The Relationship of Adherence to the Mediterranean Diet with Disease Activity and Quality of Life in Crohn’s Disease Patients
by Athanasios Migdanis, Ioannis Migdanis, Nikoleta D. Gkogkou, Sousana K. Papadopoulou, Constantinos Giaginis, Athanasios Manouras, Maria Anna Polyzou Konsta, Rena I. Kosti, Konstantinos A. Oikonomou, Konstantinos Argyriou, Spyridon Potamianos and Andreas Kapsoritakis
Medicina 2024, 60(7), 1106; https://doi.org/10.3390/medicina60071106 - 8 Jul 2024
Cited by 1 | Viewed by 2213
Abstract
Background and Objectives: Emerging evidence is placing the Mediterranean diet (MD) in the spotlight as a potential dietary model that could benefit inflammatory bowel disease (IBD) patients in terms of prevention and progress of the disease. The main aim of the present [...] Read more.
Background and Objectives: Emerging evidence is placing the Mediterranean diet (MD) in the spotlight as a potential dietary model that could benefit inflammatory bowel disease (IBD) patients in terms of prevention and progress of the disease. The main aim of the present study is to shed some light on the relationship between the adherence to the MD and the degree of disease activity, as well as the quality of life in patients with Crohn’s disease (CD). Materials and Methods: An administered questionnaire was used to assess and record a number of parameters, including recent medical and weight history, anthropometric characteristics, disease activity (in remission or active disease), and quality of life of both male and female CD patients. Moreover, the level of compliance of the participants to the Mediterranean diet model was evaluated and its relationship with disease activity and quality of life was investigated. Results: Adherence to the MD was significantly higher in patients with inactive disease than in those with active disease (p = 0.019). According to the correlation analysis conducted, adherence to the MD was negatively correlated with disease activity (p = 0.039) and positively correlated with quality of life (QoL) (p = 0.046) of the participants. Intake of fruits, vegetables, and dairy products was significantly higher in remission patients (p = 0.046, p = 0.001, p = 0.041, respectively). Conclusions: We conclude, according to the findings of the study, that adherence to the MD is associated with disease activity and QoL in patients with CD. Future research should focus on MD intervention studies on IBD patients in order to assess its effect on modulating disease activity/course and related inflammatory biomarkers. Full article
(This article belongs to the Special Issue Importance and Consequences of Nutrition and Diet Plans for the Management of Gastrointestinal Disorders)
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12 pages, 471 KiB  
Article
Adherence to the Mediterranean Diet in Saudi Arabia and Its Association with Socioeconomic Status and Depression
by Majed Alnabulsi, Ahmad Abdullah Imam, Atheer Ahmed Alawlaqi, Fatimah Hussain Alhawaj, Ghazal Fareed Jamjoom, Lina Dakhil Alsaeidi, Fatma El-Sayed Hassan and Shakeel Ahmed Ansari
Medicina 2024, 60(4), 642; https://doi.org/10.3390/medicina60040642 - 17 Apr 2024
Cited by 4 | Viewed by 2198
Abstract
Background and Objectives: Several RCTs have reported significant reductions in depression symptoms with the Mediterranean diet (MedDiet), but observational studies have reported inconsistent findings. Moreover, studies have rarely investigated the mediating role of socioeconomic status (SES), including objective material status, in adherence to [...] Read more.
Background and Objectives: Several RCTs have reported significant reductions in depression symptoms with the Mediterranean diet (MedDiet), but observational studies have reported inconsistent findings. Moreover, studies have rarely investigated the mediating role of socioeconomic status (SES), including objective material status, in adherence to the MedDiet and its impact on depressive symptoms in the same population. Therefore, this cross-sectional study investigated the relationship between adherence to the MedDiet, socioeconomic factors, and depression severity. Materials and Methods: A cross-sectional online survey was conducted between June and December 2022 across Saudia Arabia. The snowball sampling technique was used to recruit participants aged ≥18 years. Mediterranean diet adherence screener (MEDAS) and Patient Health Questionnaire-9 (PHQ-9) were used to assess adherence to the MedDiet and depression severity. An SES index, validated in the Saudi Arabian context, was used to assess SES. The data were analyzed using the Chi-square and Pearson’s correlation tests. Results: Only 21% of our study population (n = 467) was MedDiet adherent. Adherence was significantly associated with education (p = 0.014) but not employment status among traditional SES indicators. Similarly, only television ownership (p = 0.009) was associated with MedDiet adherence among the 20 objective material possessions investigated. Nonetheless, the MedDiet-adherent group had a significantly lower PHQ-9 score than the non-adherent group (6.16 ± 0.68 vs. 8.35 ± 0.31, p = 0.002). A moderate but significantly negative correlation between MEDAS and PHQ-9 scores (r = −0.16, p = 0.001) was noted. Conclusions: MedDiet adherence was associated with lower depression severity scores. In addition to education and television ownership, adherence was not associated with any objective indicators of SES. Full article
(This article belongs to the Special Issue Importance and Consequences of Nutrition and Diet Plans for the Management of Gastrointestinal Disorders)
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13 pages, 978 KiB  
Article
Investigating Bioaccessibility of Advanced Glycation Product Precursors in Gluten-Free Foods Using In Vitro Gastrointestinal System
by Yeliz Serin, Gamze Akbulut and Mustafa Yaman
Medicina 2023, 59(9), 1578; https://doi.org/10.3390/medicina59091578 - 30 Aug 2023
Cited by 2 | Viewed by 1775
Abstract
Background and Objectives: Gluten-free products have been produced as part of medical therapy and have gained popularity among individuals seeking weight loss or healthier dietary options. Assessing the potential risks associated with these products is essential in optimizing their compositions and developing new [...] Read more.
Background and Objectives: Gluten-free products have been produced as part of medical therapy and have gained popularity among individuals seeking weight loss or healthier dietary options. Assessing the potential risks associated with these products is essential in optimizing their compositions and developing new dietetic approaches. This study aimed to determine the glyoxal (GO) and methylglyoxal (MGO) contents in gluten-free bread, biscuits, and cookies and to examine their bioaccessibility using an in vitro gastrointestinal model. Materials and Methods: A total of 26 gluten-free and 19 gluten-containing (control) products were analyzed for their GO and MGO levels utilizing a high-performance liquid chromatography (HPLC) device. Results: Post-digestion, the GO and MGO values increased significantly across all food groups compared with pre-digestion values (p < 0.05), and the bioaccessibility exceeded 100%. Specifically, gluten-free bread exhibited higher post-digestion GO and MGO values than the control group (p < 0.05). Conversely, gluten-containing biscuits and cookies had higher post-digestion GO and MGO values compared to gluten-free products (p < 0.05). Conclusions: The detection of precursors to advanced glycation end products (AGEs) in gluten-free products has drawn attention to the potential health risks associated with their consumption. Therefore, reevaluation of the formulations and technologies used in these products and the introduction of new strategies are crucial in mitigating AGE content. Full article
(This article belongs to the Special Issue Importance and Consequences of Nutrition and Diet Plans for the Management of Gastrointestinal Disorders)
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16 pages, 1417 KiB  
Article
Assessment of the Phytochemical Profile, Antioxidant Capacity, and Hepatoprotective Effect of Andrographis paniculata against CCl4-Induced Liver Dysfunction in Wistar Albino Rats
by Syed Kashif Ali, Hafiz A. Makeen, Gulrana Khuwaja, Hassan A. Alhazmi, Mukul Sharma, Afraim Koty, Islam Mazahirul, Humaira Parveen, Asaduddin Mohammed, Sayeed Mukhtar and Mohammad Firoz Alam
Medicina 2023, 59(7), 1260; https://doi.org/10.3390/medicina59071260 - 6 Jul 2023
Cited by 8 | Viewed by 4268
Abstract
Recent studies have highlighted the necessity to thoroughly evaluate medicinal plants due to their therapeutic potential. The current study delves into the phytochemical profile, antioxidant capacity, and hepatoprotective effect of Andrographis paniculata. The investigation specifically targets its effectiveness in mitigating liver dysfunction induced by [...] Read more.
Recent studies have highlighted the necessity to thoroughly evaluate medicinal plants due to their therapeutic potential. The current study delves into the phytochemical profile, antioxidant capacity, and hepatoprotective effect of Andrographis paniculata. The investigation specifically targets its effectiveness in mitigating liver dysfunction induced by carbon tetrachloride (CCl4) in Wistar albino rats, aiming to uncover its promising role as a natural remedy for liver-related ailments. A. paniculata leaf extract was screened for phytoconstituents and antioxidant and hepatoprotective effects in Wistar albino rats against CCl4-induced liver dysfunction. Phytochemical analysis revealed the presence of flavonoids, alkaloids, and phenolic compounds in all extracts. The phenolic concentration ranged from 10.23 to 19.52 mg gallic acid per gram of the sample, while the highest flavonoid concentration was found in the ethanol fraction (8.27 mg rutin equivalents per gram). The antioxidant activity varied from 10.23 to 62.23. GC-MS analysis identified several phytochemicals including octadecanoic acid, stigmasterol, phenanthrenecarboxylic acid, and others. Effects of the ethanol extract of A. paniculata were evaluated in four groups of animals. Biochemical estimations of serum glutamine oxaloacetate transaminase, serum glutamine pyruvate transaminase, and serum bilirubin were significantly higher (p < 0.05) in the CCl4-treated group. Treatment with 300 mg/kg b.w. of the ethanol extract of A. paniculata significantly (p < 0.05) decreased these serum enzymes. Lipid peroxidation levels in carbon tetrachloride-treated animals showed a substantial (p < 0.05) rise when compared to untreated animals, while the lipid peroxidation levels were considerably (p < 0.05) reduced after treatment with ethanol extract at 300 mg/kg b.w. Liver biochemical catalase activities were significantly reduced in the carbon tetrachloride-treated animals. The results of this study conclusively demonstrate that A. paniculata extracts are a rich source of phytochemicals and possess significant antioxidant, free radical scavenging, and hepatoprotective properties. Full article
(This article belongs to the Special Issue Importance and Consequences of Nutrition and Diet Plans for the Management of Gastrointestinal Disorders)
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