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Dietary Lipid and Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 1543

Special Issue Editor


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Guest Editor
Human Aging Research Institute, School of Life Sciences, Nanchang University, Nanchang 330031, China
Interests: sphingolipids; sphingolipid metabolism; dietary lipids; fatty acids; aging; human health
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Special Issue Information

Dear Colleagues,

Lipids are essential components of living organisms and support multiple biological and physiological functions in the human body, and they are recognized as important biomarkers of disease and are involved in several pathological conditions. Lipids possess a wide range of biological activities in plants, animals and humans. Numerous animal and human studies suggest that dietary lipids serve as important components of our daily diet and provide both energy and essential fatty acids, and they also act as carriers of fat-soluble vitamins and help in their absorption. The influence of dietary lipids on the nature and constituents of adipose tissue is well recognized.

In summary, this Special Issue aims to provide a contemporary understanding of food lipids in nutrition and health, especially the underlying cellular and molecular mechanisms of the actions of these bioactive dietary lipids. We invite the submission of original articles and reviews that highlight the history and deepen our current understanding of dietary fatty acids and dietary lipids in human health.

Prof. Dr. Jingjing Duan
Guest Editor

Manuscript Submission Information

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Keywords

  • dietary lipids
  • dietary fatty acids
  • metabolic diseases
  • cancer
  • cardiovascular health

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Published Papers (1 paper)

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Research

13 pages, 1981 KiB  
Article
N-Acetylcysteine Alleviates Impaired Muscular Function Resulting from Sphingosine Phosphate Lyase Functional Deficiency-Induced Sphingoid Base and Ceramide Accumulation in Caenorhabditis elegans
by Min Liu, Yunfei You, Huaiyi Zhu, Yu Chen, Zhenying Hu and Jingjing Duan
Nutrients 2024, 16(11), 1623; https://doi.org/10.3390/nu16111623 - 26 May 2024
Viewed by 1062
Abstract
Sphingosine-1-phosphate lyase (SPL) resides at the endpoint of the sphingolipid metabolic pathway, catalyzing the irreversible breakdown of sphingosine-1-phosphate. Depletion of SPL precipitates compromised muscle morphology and function; nevertheless, the precise mechanistic underpinnings remain elusive. Here, we elucidate a model of SPL functional deficiency [...] Read more.
Sphingosine-1-phosphate lyase (SPL) resides at the endpoint of the sphingolipid metabolic pathway, catalyzing the irreversible breakdown of sphingosine-1-phosphate. Depletion of SPL precipitates compromised muscle morphology and function; nevertheless, the precise mechanistic underpinnings remain elusive. Here, we elucidate a model of SPL functional deficiency in Caenorhabditis elegans using spl-1 RNA interference. Within these SPL-deficient nematodes, we observed diminished motility and perturbed muscle fiber organization, correlated with the accumulation of sphingoid bases, their phosphorylated forms, and ceramides (collectively referred to as the “sphingolipid rheostat”). The disturbance in mitochondrial morphology was also notable, as SPL functional loss resulted in heightened levels of reactive oxygen species. Remarkably, the administration of the antioxidant N-acetylcysteine (NAC) ameliorates locomotor impairment and rectifies muscle fiber disarray, underscoring its therapeutic promise for ceramide-accumulation-related muscle disorders. Our findings emphasize the pivotal role of SPL in preserving muscle integrity and advocate for exploring antioxidant interventions, such as NAC supplementation, as prospective therapeutic strategies for addressing muscle function decline associated with sphingolipid/ceramide metabolism disruption. Full article
(This article belongs to the Special Issue Dietary Lipid and Human Health)
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