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Effects of a Gluten-Free Diet and a Low-FODMAP Diet on Irritable Bowel Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 25 December 2024 | Viewed by 376

Special Issue Editors


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Guest Editor
European Laboratory for the Investigation of Food Induced Disease (ELFID), University Federico II, Via Pansini 5, 80131 Naples, Italy
Interests: celiac disease; autoimmunity; food-induced diseases; mucosal immunology; pediatric obesity

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Guest Editor
Department of Chemistry Biological Farmaceutical and Environmental Sciences, University of Messina, Viale Annunziata, 98168 Messina, Italy
Interests: pediatric gastroenterology; disorders of gut–brain interations; nutrition; pediatrics
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Special Issue Information

Dear Colleagues,

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID), of which the prevalence has widely increased within the pediatric population over the past two decades. The pathophysiological mechanism underlying IBS is still uncertain, making the diagnosis and management of this disease challenging.

Most IBS patients report gastro-intestinal (GI) symptoms in relation with food consumption, although a cause–effect relationship between the ingestion of a specific food and the onset of symptoms is often difficult to prove, particularly in children. In the absence of reliable diagnostic tests, empirical dietary regimes that employ restrictions of certain foods are often indicated in the absence of a proven alternative diagnosis, including celiac disease, malabsorption or food allergies. This is relevant, as changes in diet can interfere with the individual metabolism, intestinal motility, gut microbiota and nutritional status. Moreover, unnecessary dietary restrictions are of particular concern in growing children. Therefore, it is of great importance to have a deep understanding of the evidence behind each dietary recommendation given to children in order to design personalized treatment plans.

The aim of this Special Issue is to provide an update on the state of the art of the role of diet in the context of IBS, with a particular focus on evidence that supports or discourages a gluten-free diet and/or a low-FODMAP diet in children and adults with IBS.

Dr. Valentina Discepolo
Dr. Marina Russo
Guest Editors

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Keywords

  • IBS
  • FGID
  • diet
  • low-FODMAPs diet
  • gluten-free diet
  • diet therapy
  • children
  • celiac disease

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Published Papers (1 paper)

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Research

16 pages, 2784 KiB  
Article
Dietary Bovine Lactoferrin Reduces the Deleterious Effects of Lipopolysaccharide Injection on Mice Intestine
by Anne Blais, Natsuko Takakura, Marta Grauso, Caroline Puel-Artero, François Blachier and Annaïg Lan
Nutrients 2024, 16(23), 4040; https://doi.org/10.3390/nu16234040 - 26 Nov 2024
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Abstract
Background/Objectives: Injection of lipopolysaccharides (LPS) in experimental models induces a systemic inflammatory response that is associated with deleterious effects on intestinal morphology and physiology. In this study, we have studied in female mice the effects of dietary supplementation with bovine lactoferrin (bLF) given [...] Read more.
Background/Objectives: Injection of lipopolysaccharides (LPS) in experimental models induces a systemic inflammatory response that is associated with deleterious effects on intestinal morphology and physiology. In this study, we have studied in female mice the effects of dietary supplementation with bovine lactoferrin (bLF) given before intraperitoneal injection of LPS on jejunum and colon. Methods: The first study evaluated the efficiency of different bLF and LPS concentrations to determine the optimal experimental conditions. For the second study mice were fed with 1% bLF before the LPS challenge (3 mg/kg body weight). Plasmatic markers of inflammation, intestinal morphology, permeability, and expression of genes related to epithelial differentiation, epithelial barrier function and intestinal inflammation in both small intestine and colon were evaluated. Results: bLF ingestion before the LPS challenge reduced the TNF-α circulating concentration, compared to control animals. This decrease in plasma TNF-α was correlated with improved intestinal permeability. The morphology of jejunal epithelium, which was affected by LPS challenge, was partly maintained by bLF. Measurement of the expression of genes encoding proteins involved in epithelial differentiation, intestinal inflammation, and epithelial barrier function suggests an overall protective effect of bLF against the adverse effects of LPS in the jejunum. In the colon, the effects of bLF ingestion on the subsequent LPS challenge, although protective, remain different when compared with those observed on jejunum. Conclusions: Taken together, our data indicate that bLF dietary supplementation does have a protective effect on the deleterious intestinal alterations induced by LPS systemic inflammation. Full article
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