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Nutrition and Lifestyle Behaviours for the Prevention and Management of Multiple Sclerosis

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 15 February 2025 | Viewed by 716

Special Issue Editors


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Guest Editor
School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2522, Australia
Interests: multiple sclerosis; diet; nutrition; dietary methodology; health behaviours; clinical trial; consumer engagement; food composition; dietary patterns; food choice; lifestyle; lived experience; supplementation; alcohol; quality of life
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Internal Medicine, University of Iowa, Iowa City, IA 52340, USA
Interests: multiple sclerosis; neurodegeneration; diet; nutrition; dietetics; randomized controlled trials; nutritional epidemiology; comorbidity burden; dietary assessment; nutrition screening; dietary patterns; quality of life; fatigue

Special Issue Information

Dear Colleagues,

Multiple sclerosis (MS) is a chronic, immune-mediated, neurodegenerative disease that affects over 2.9 million people worldwide. In recent years, lifestyle behaviours have gained much interest in the MS community for their role in improving wellness and managing symptoms. However, given the current inconsistency in this emerging field, many questions remain, including the role of lifestyle behaviours in the prevention of MS, the impact of lifestyle behaviours on disease progression, the mechanisms by which lifestyle behaviours improve outcomes, and the role of lifestyle behaviours in the clinical management of MS, among others.

This Special Issue seeks to advance our knowledge regarding lifestyle behaviours and MS. Particularly, studies are sought related to the identification or implementation of health behaviour management approaches, including but not limited to diet, supplementation, physical activity, stress management, sleep, and smoking avoidance. Original research (including trials, observational studies, qualitative studies, animal models, etc.) and reviews (systematic, scoping, narrative, etc.) are eligible for submissions.

Dr. Yasmine Probst
Dr. Tyler J. Titcomb
Guest Editors

Manuscript Submission Information

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Keywords

  • multiple sclerosis
  • nutrition
  • diet
  • exercise
  • physical activity
  • sleep
  • stress management
  • comorbidities
  • malnutrition
  • microbiome
  • health behaviour

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Published Papers (1 paper)

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Research

13 pages, 1519 KiB  
Article
Nuclear-Magnetic-Resonance-Spectroscopy-Derived Serum Biomarkers of Metabolic Vulnerability Are Associated with Disability and Neurodegeneration in Multiple Sclerosis
by Taylor R. Wicks, Irina Shalaurova, Richard W. Browne, Anna Wolska, Bianca Weinstock-Guttman, Robert Zivadinov, Alan T. Remaley, James D. Otvos and Murali Ramanathan
Nutrients 2024, 16(17), 2866; https://doi.org/10.3390/nu16172866 - 27 Aug 2024
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Abstract
Purpose: Metabolic vulnerabilities can exacerbate inflammatory injury and inhibit repair in multiple sclerosis (MS). The purpose was to evaluate whether blood biomarkers of inflammatory and metabolic vulnerability are associated with MS disability and neurodegeneration. Methods: Proton nuclear magnetic resonance spectra were obtained from [...] Read more.
Purpose: Metabolic vulnerabilities can exacerbate inflammatory injury and inhibit repair in multiple sclerosis (MS). The purpose was to evaluate whether blood biomarkers of inflammatory and metabolic vulnerability are associated with MS disability and neurodegeneration. Methods: Proton nuclear magnetic resonance spectra were obtained from serum samples from 153 healthy controls, 187 relapsing–remitting, and 91 progressive MS patients. The spectra were analyzed to obtain concentrations of lipoprotein sub-classes, glycated acute-phase proteins, and small-molecule metabolites, including leucine, valine, isoleucine, alanine, and citrate. Composite indices for inflammatory vulnerability, metabolic malnutrition, and metabolic vulnerability were computed. MS disability was measured on the Expanded Disability Status Scale. MRI measures of lesions and whole-brain and tissue-specific volumes were acquired. Results: Valine, leucine, isoleucine, alanine, the Inflammatory Vulnerability Index, the Metabolic Malnutrition Index, and the Metabolic Vulnerability Index differed between healthy control and MS groups in regression analyses adjusted for age, sex, and body mass index. The Expanded Disability Status Scale was associated with small HDL particle levels, inflammatory vulnerability, and metabolic vulnerability. Timed ambulation was associated with inflammatory vulnerability and metabolic vulnerability. Greater metabolic vulnerability and inflammatory vulnerability were associated with lower gray matter, deep gray matter volumes, and greater lateral ventricle volume. Conclusions: Serum-biomarker-derived indices of inflammatory and metabolic vulnerability are associated with disability and neurodegeneration in MS. Full article
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