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Micronutrients in Women’s Health and Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 4713

Special Issue Editor


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Guest Editor

Special Issue Information

Dear Colleagues,

Vitamins and minerals, collectively known as micronutrients, are essential components of our diet. However, this does not mean that the demand for micronutrients in women and men is the same. On the contrary, the differences are significant due to the specificity of hormonal activity. Moreover, these differences occur among women themselves, which depends on differentiation in the hormonal profile related to age. The proper supply of micronutrients must therefore take into account many important circumstances. Otherwise, it can lead both minor disorders in the functioning of the body and serious diseases. For this reason, research on the presence of micronutrients in the diet and dietary supplements is very valuable from both a cognitive and a practical point of view. All interested in this subject are encouraged to submit valuable scientific articles to this Special Issue. Original articles, reviews and case reports are welcome.

Prof. Dr. Dariusz Chlubek
Guest Editor

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Keywords

  • women
  • pregnant women
  • postmenopausal period
  • feminine adolescence
  • trace elements
  • vitamins
  • vitamin toxicity
  • mineral toxicity
  • vitamin deficiency
  • mineral deficiency

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Published Papers (2 papers)

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Research

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19 pages, 2837 KiB  
Article
Impact of Lactobacillus acidophilus and Its Combination with Isoflavone Products on Calcium Status, Calcium Transporters, and Bone Metabolism Biomarkers in a Post-Menopausal Osteoporotic Rat Model
by Iskandar Azmy Harahap, Marcin Schmidt, Ewa Pruszyńska-Oszmałek, Maciej Sassek and Joanna Suliburska
Nutrients 2024, 16(15), 2524; https://doi.org/10.3390/nu16152524 - 2 Aug 2024
Viewed by 1854
Abstract
Osteoporosis in menopausal women requires alternatives to current medications, considering their adverse effects. In this context, probiotics and isoflavone products are promising dietary interventions. The objective of our study was to examine the impacts of Lactobacillus acidophilus and its combination with daidzein and [...] Read more.
Osteoporosis in menopausal women requires alternatives to current medications, considering their adverse effects. In this context, probiotics and isoflavone products are promising dietary interventions. The objective of our study was to examine the impacts of Lactobacillus acidophilus and its combination with daidzein and tempeh on calcium status, calcium transporters, and bone metabolism biomarkers in a post-menopausal osteoporotic rat model. A total of 48 female Wistar rats were exposed to a two-stage experiment involving calcium deficit induction and subsequent dietary interventions across six groups. Calcium levels, the gene expression of TRPV5 and TRPV6 calcium transporters, bone histopathology, serum bone metabolism markers, and blood biochemistry were evaluated. The results revealed that, while decreasing serum calcium levels, the groups that received the probiotic L. acidophilus and isoflavone combination exhibited increased bone metabolism biomarkers and decreased calcium transporter expressions, akin to the effects of bisphosphonate. Additionally, significant improvements in bone histopathology were observed in these groups. However, the group receiving probiotic L. acidophilus alone did not exhibit significant changes in bone resorption biomarkers, calcium transporter expression, or various blood parameters. Meanwhile, the combination of probiotic L. acidophilus with tempeh positively influenced hematological parameters and reduced cholesterol and triglyceride levels, but it led to elevated blood glucose levels. Correlation analyses highlighted associations between serum calcium levels, calcium transporter expression, and bone metabolism biomarkers. In conclusion, our findings suggest that the daily consumption of probiotic L. acidophilus in combination with isoflavone products may improve bone health in ovariectomized rats, warranting further research to elucidate potential interactions with other nutrients. Full article
(This article belongs to the Special Issue Micronutrients in Women’s Health and Disease)
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Review

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17 pages, 876 KiB  
Review
Vitamins in Gynecologic Malignancies
by Natalia Wierzbowska, Tomasz Olszowski, Dariusz Chlubek, Mateusz Kozłowski and Aneta Cymbaluk-Płoska
Nutrients 2024, 16(9), 1392; https://doi.org/10.3390/nu16091392 - 5 May 2024
Cited by 1 | Viewed by 2339
Abstract
The combination of vitamin A and D derivatives with classical chemotherapeutic treatments results in more satisfactory outcomes. The use of drug combinations, such as 9cUAB130 with carboplatin and cisplatin with TAC-101, shows enhanced cytotoxic effects and reductions in ovarian tumor volume compared to [...] Read more.
The combination of vitamin A and D derivatives with classical chemotherapeutic treatments results in more satisfactory outcomes. The use of drug combinations, such as 9cUAB130 with carboplatin and cisplatin with TAC-101, shows enhanced cytotoxic effects and reductions in ovarian tumor volume compared to single-drug treatments. Combining cisplatin with calcitriol and progesterone increases VDR expression, potentially enhancing the effectiveness of anticancer therapy in ovarian cancer. The effectiveness of vitamin derivatives in anticancer treatment may vary depending on the characteristics of the tumor and the cell line from which it originated. An increase in thiamine intake of one unit is associated with an 18% decrease in HPV infection. Higher intake of vitamin C by 50 mg/day is linked to a lower risk of cervical neoplasia. Beta-carotene, vitamin C, and vitamin E are associated with risk reductions of 12%, 15%, and 9% in endometrial cancer, respectively. A balanced daily intake of vitamins is important, as both deficiency and excess can influence cancer development. It has been observed that there is a U-shaped relationship between group B vitamins and metabolic markers and clinical outcomes. Full article
(This article belongs to the Special Issue Micronutrients in Women’s Health and Disease)
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