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The Role of Bioactive Compounds in Human Health and Diseases (2nd Edition)

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 726

Special Issue Editor


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Guest Editor
Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Interests: obesity; inflammation; immunity; bioactive compounds; nutrition; apolipoproteins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bioactive compounds are being studied to better understand their effects on health and disease. These compounds are found in several foods, such as beverages (wine, cedar, juices), vegetable oils, spices (curcuma, pepper, etc.), teas and infusions. Through the results of in vitro or in vivo studies, some of these compounds have already showed several potentially beneficial effects on human health and in the prevention of disease. Plant bioactive compounds are of great interest in this area due to the range of compound varieties and actions, such as thermogenesis, inflammation, metabolism and endocrine factors.

More research is needed to explore their use in improving physical performance; the aging process; or preventing or helping treat diseases such as obesity, CVD, diabetes mellitus tumors and inflammatory processes in general.

In this context, we invite you to submit your research work or experience to the Special Issue “The Role of Bioactive Compounds in Human Health and Diseases (2nd Edition)”. Clinical, experimental and in vitro studies, as well as reviews on the effects of bioactive compounds in obesity and its comorbidities, are welcome.

Prof. Dr. Jacqueline Isaura Alvarez-Leite
Guest Editor

Manuscript Submission Information

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Keywords

  • bioactive compounds
  • obesity
  • diabetes
  • tumors
  • inflammatory
  • cardiovascular disease
  • plants
  • immunity
  • diet
  • nutrition

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Published Papers (1 paper)

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Research

12 pages, 2186 KiB  
Article
Antihypertensive Effects of Lindera erythrocarpa Makino via NO/cGMP Pathway and Ca2+ and K+ Channels
by Sujin Shin, Junkyu Park, Ho-Young Choi, Youngmin Bu and Kyungjin Lee
Nutrients 2024, 16(17), 3003; https://doi.org/10.3390/nu16173003 - 5 Sep 2024
Viewed by 502
Abstract
Studies have demonstrated the therapeutic effects of Lindera plants. This study was undertaken to reveal the antihypertensive properties of Lindera erythrocarpa leaf ethanolic extract (LEL). Aorta segments of Sprague–Dawley rats were used to study the vasodilatory effect of LEL, and the mechanisms involved [...] Read more.
Studies have demonstrated the therapeutic effects of Lindera plants. This study was undertaken to reveal the antihypertensive properties of Lindera erythrocarpa leaf ethanolic extract (LEL). Aorta segments of Sprague–Dawley rats were used to study the vasodilatory effect of LEL, and the mechanisms involved were evaluated by treating specific inhibitors or activators that affect the contractility of blood vessels. Our results revealed that LEL promotes a vasorelaxant effect through the nitric oxide/cyclic guanosine 3′,5′-monophosphate pathway, blocking the Ca2+ channels, opening the K+ channels, and inhibiting the vasoconstrictive action of angiotensin II. In addition, the effects of LEL on blood pressure were investigated in spontaneously hypertensive rats by the tail-cuff method. LEL (300 or 1000 mg/kg) was orally administered to the rats, and 1000 mg/kg of LEL significantly lowered the blood pressure. Systolic blood pressure decreased by −20.06 ± 4.87%, and diastolic blood pressure also lowered by −30.58 ± 5.92% at 4 h in the 1000 mg/kg LEL group. Overall, our results suggest that LEL may be useful to treat hypertensive diseases, considering its vasorelaxing and hypotensive effects. Full article
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