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Effects of Vitamin D Deficiency on Human Health, Nutritional Status, and Disease Prevention with Micronutrients

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: 25 January 2025 | Viewed by 1209

Special Issue Editor

Prof. Dr. Sunil J. Wimalawansa

E-Mail Website
Guest Editor
Endocrinology & Nutrition, Department of Medicine, Cardiometabolic & Endocrine Institute, North Brunswick, NJ 08873, USA
Interests: micronutrients; vitamin D; COVID-19; bone; endocrinology; minerals; molecualr mechansisums, preventive medicine; environmental science

Special Issue Information

Dear Colleagues,

This Special Issue (SI) focuses on vitamin D and micronutrients' clinical and research aspects in human health and disease prevention. Understanding and applying knowledge of the biology and physiology of vitamin D are crucial for disease prevention and as adjunct therapy in treatment. This SI also accepts articles related to the molecular mechanisms of action, synergy, and interactions of nutrients concerning body systems such as the cardiovascular, gastrointestinal, and immune systems. Editors expect manuscripts to encompass a broader outlook combining biology, biochemistry, pharmacology, and especially the clinical aspects of the disease status of interest to benefit the readership. This SI will also consider articles related to science-based policy decision making concerning vitamins, especially vitamin D, critiquing recently published large vitamin D clinical trials and the 2024 Endocrine Society Clinical Practice Guidelines (https://doi.org/10.1210/clinem/dgae290), as well as articles related to the impact of vitamin D on human health.

Prof. Dr. Sunil J. Wimalawansa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biology and physiology
  • nutrition
  • micronutrients—vitamins and minerals
  • infections—immune system
  • mechanisms
  • clinical studies/RCTs—data analyses

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Published Papers (1 paper)

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Research

13 pages, 1193 KiB  
Article
Vitamin D Deficiency: Insights and Perspectives from a Five-Year Retrospective Analysis of Children from Northeastern Romania
by Gabriela Ghiga, Elena Țarcă, Viorel Țarcă, Elena Lia Spoială, Gabriela Păduraru, Nicoleta Gimiga, Laura Otilia Boca, Otilia Iftinchi, Mădălina Andreea Donos, Lorena Mihaela Manole and Laura Mihaela Trandafir
Nutrients 2024, 16(22), 3808; https://doi.org/10.3390/nu16223808 - 7 Nov 2024
Viewed by 877
Abstract
Background: Vitamin D plays an important role in maintaining bone health with numerous benefits for extraskeletal health as well. Objectives: We aimed to assess the prevalence of vitamin D deficiency in children (0–18 years old) in a tertiary hospital in Romania between August [...] Read more.
Background: Vitamin D plays an important role in maintaining bone health with numerous benefits for extraskeletal health as well. Objectives: We aimed to assess the prevalence of vitamin D deficiency in children (0–18 years old) in a tertiary hospital in Romania between August 2019 and January 2024 and to investigate the role of adequate supplementation in this vulnerable population. Methods: The serum 25(OH)D levels were measured using a chemiluminescence binding assay. Results: A total of 744 participants were included in this study: 396 female (53.23%) and 348 male (46.77%). The serum levels of 25(OH)D ranged between 2.2 and 125.4 ng/mL, with a mean value of 27.4 ng/mL and a median value of 23.5 ng/mL. According to the cutoff values for the definition of vitamin D status (severe deficiency: <10 ng/mL, deficiency: <20 ng/mL, insufficiency: 20–29 ng/mL, and sufficiency: ≥30 ng/mL), the sample consisted of 77 (10.34%) cases of severe deficiency, 221 (29.7%) cases of deficiency, 194 (26.07%) cases of insufficiency, and 245 (32.93%) cases of sufficiency. There were seven cases of hypervitaminosis D with values above 100 ng/mL. The mean values (and corresponding 95% confidence intervals, CIs) were as follows: 27.85 ng/mL [25.95–29.76] in the males, 22.45 ng/mL [25.12–28.82] in the females, 24.82 ng/mL [21.86–27.77] in the spring, 28.62 ng/mL [26.42–30.81] in the summer, 32.30 ng/mL [29.16–35.44] in the autumn, and 24.01 ng/mL [21.57–26.44] in the winter. We observed a notable decline in the serum 25(OH)D levels with age, with 82.08% of the children in the age group above 6 years old having serum 25(OH)D levels below 30 ng/mL. In obese subjects, a higher prevalence of hypovitaminosis D was observed compared to non-obese subjects, with a mean value of 19.54 [17.50–21.57] ng/mL in obese children versus 28.89 [27.39–30.40] ng/mL in normal weight children. Conclusions: In our sample, the mean serum concentration of 25(OH)D was 27.4 ng/mL. Notably, 66.11% of the cases demonstrated varying degrees of hypovitaminosis D, with a significantly higher prevalence of 86.16% observed in the obese group. Healthcare providers should prioritize routine screening for vitamin D levels in pediatric patients with obesity to facilitate timely intervention and personalized supplementation strategies tailored to individual needs Full article
(This article belongs to the Special Issue Effects of Vitamin D Deficiency on Human Health, Nutritional Status, and Disease Prevention with Micronutrients)
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