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Nutrients
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The Nutritional Management of Food Allergy in Children
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The Nutritional Management of Food Allergy in Children

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Immunology".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 1844

Special Issue Editor

Dr. Minyoung Jung

E-Mail Website
Guest Editor
Department of Pediatrics, Kosin University Gospel Hospital, Kosin University School of Medicine, Busan 49267, Republic of Korea
Interests: food allergy; nutrition; paediatrics; atopic dermatitis; environment; immunotherapy

Special Issue Information

Dear Colleagues,

Food allergies (FAs) in children not only necessitate the strict avoidance of known allergens but also place a significant burden on caregivers to manage children’s diets effectively. This dietary management can lead to considerable nutritional gaps, as studies reveal that such restrictions often lead to the reduced intake of crucial nutrients. Nutritional deficiencies are particularly alarming during the pivotal growth and developmental stages of a child's life and may impact immune function and the gut microbiome, which may be related to acquiring immune tolerance. In addition, the dietary management of FAs for children may be burdensome and psychologically distressing for caregivers.

While the debate continues on how FAs may affect physical growth, the consensus is clear on one idea: the management of optimal nutrition and a high-quality diet for children with FA requires substantially more effort from parents than is necessary for children without allergies.

Consequently, it is crucial to research various methodologies that allow children with FA to not only avoid allergens but also enjoy high-quality meals. Furthermore, it is essential to investigate whether there are specific nutritional or dietary patterns that could aid in developing immune tolerance. This Special Issue on "The Nutritional Management of Food Allergy in Children" aims to shed light on these issues, offering insights and guidance to support families navigating this complex challenge.

Dr. Minyoung Jung
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food allergy
  • nutrition
  • dietary management
  • gut microbiome
  • parental burden
  • quality of life
  • immunonutrition
  • tolerance

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Published Papers (1 paper)

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Research

15 pages, 1490 KiB  
Article
Growth, Safety and Tolerance in Infants Fed Rice Protein Hydrolysate Formula: The GRITO Randomised Controlled Trial
by Anaïs Lemoine, Antonio Nieto-García, María Nieto-Cid, Beatriz Espín-Jaime, Ángel Mazón, Hocine Salhi, Dimitrios Salamouras, Nicolas Kalach, Roser de Castellar-Sansó, Jesús Delgado Ojeda and Víctor Manuel Navas-López
Nutrients 2025, 17(1), 162; https://doi.org/10.3390/nu17010162 - 31 Dec 2024
Cited by 1 | Viewed by 1431
Abstract
Background: Hydrolysed rice formula (HRF) is tolerated by >90% of children with cow’s milk protein allergy (CMPA). However, concerns have been raised about potential suboptimal growth in infants fed HRF compared to those fed an extensively hydrolysed milk protein formula (eHF). Aims [...] Read more.
Background: Hydrolysed rice formula (HRF) is tolerated by >90% of children with cow’s milk protein allergy (CMPA). However, concerns have been raised about potential suboptimal growth in infants fed HRF compared to those fed an extensively hydrolysed milk protein formula (eHF). Aims: To compare growth, safety and tolerance acquisition in infants with CMPA when fed HRF versus eHF. Methods: A multicentre prospective, randomised, double-blind, placebo-controlled food challenge trial was conducted with infants with CMPA. The infants received either HRF or eHF over a 12-month follow-up period. The primary outcome measure was the change from baseline over the study period in weight-for-length expressed as a Z-score. The secondary outcomes were other anthropometric measurements, tolerability and adverse events (AEs). Results: In total, 105 children were enrolled. The weight-for-length measurements were −0.01 (HRF) and −0.29 (eHF) at baseline and 0.29 and 0.05, respectively, at the last visit, with no significant between-group difference (p = 0.28; mixed-effects model). The Z-scores for other anthropometric variables indicated normal growth, with no significant between-group differences. In total, 29 potentially product-related AEs were reported (12 in the HRF group and 17 in the eHF group). A trend was observed toward a faster acquisition of tolerance in the HRF group (median age: 20.4 months) compared to the eHF group (16.3 months), but this was not statistically significant (p = 0.18). Conclusions: HRF demonstrated appropriate growth, acquisition of tolerance and a good safety profile in infants with CMPA, with no significant differences versus eHF. HRF could be considered as an appropriate option in the management of CMPA. Full article
(This article belongs to the Special Issue The Nutritional Management of Food Allergy in Children)
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