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Nutrition Status and Atherosclerosis

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: closed (31 December 2019) | Viewed by 7374

Special Issue Editor


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Guest Editor
Department of Health Sciences, Magna Graecia University, Campus Germaneto, 88100 Catanzaro, Italy
Interests: nutraceuticals; heart failure; endothelial dysfunction; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There is a large body of evidence from epidemiological studies describing the potential role of diet in CVD prevention. Indeed, several studies have indicated that about 80% of coronary artery disease cases could be prevented by modifying lifestyle, specifically healthy eating habits, maintaining a healthy weight, and undertaking regular physical activity throughout the life span. Furthermore, there is accumulating experimental, epidemiological, and clinical data suggesting a clear relationship between the regular consumption of several micronutrients and a reduced risk of CVD, specifically those with antioxidant properties. Dietary antioxidants are recognized to have a protective effect against lipid peroxidation, which is associated with atherogenesis and CVD. Specifically, prospective studies suggest that supplementation of the current diet with plant extracts providing antioxidant activity is associated with lower rates of CVD mortality. Moreover, it has been reported that low circulatory levels of micronutrients and antioxidants may lead to adverse cardiovascular consequences, such as extensive and complex effects on atherosclerosis and atherogenesis. The present Special Issue will update the current status of research in the area of the correlation between nutritional states and atherosclerosis development.

Prof. Dr. Vincenzo Mollace
Guest Editor

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Keywords

  • diet supplementation
  • micronutrients
  • antioxidants
  • plant extracts
  • inflammation
  • atherosclerosis

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Published Papers (1 paper)

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Research

13 pages, 2052 KiB  
Article
Atherogenic Index Reduction and Weight Loss in Metabolic Syndrome Patients Treated with A Novel Pectin-Enriched Formulation of Bergamot Polyphenols
by Antonio Soccorso Capomolla, Elzbieta Janda, Sara Paone, Maddalena Parafati, Tomasz Sawicki, Rocco Mollace, Salvatore Ragusa and Vincenzo Mollace
Nutrients 2019, 11(6), 1271; https://doi.org/10.3390/nu11061271 - 4 Jun 2019
Cited by 35 | Viewed by 6881
Abstract
Bergamot flavonoids counteract dyslipidemia and hyperglycemia but fail to induce a significant weight loss. Here, we evaluated the efficacy of bergamot polyphenol extract complex (BPE-C), a novel bergamot juice-derived formulation enriched with flavonoids and pectins, on several metabolic syndrome parameters. Obese patients with [...] Read more.
Bergamot flavonoids counteract dyslipidemia and hyperglycemia but fail to induce a significant weight loss. Here, we evaluated the efficacy of bergamot polyphenol extract complex (BPE-C), a novel bergamot juice-derived formulation enriched with flavonoids and pectins, on several metabolic syndrome parameters. Obese patients with atherogenic index of plasma (AIP) over 0.34 and mild hyperglycemia were recruited to a double-blind randomized trial comparing two doses of BPE-C (650 and 1300 mg daily) with placebo. Fifty-two subjects met the inclusion criteria and were assigned to three experimental groups. Fifteen subjects per group completed 90 days-trial. BPE-C reduced significantly fasting glucose by 18.1%, triglycerides by 32% and cholesterol parameters by up to 41.4%, leading to a powerful reduction of AIP (below 0.2) in the high dose group. The homeostasis model assessment of insulin resistance (HOMA-IR) and insulin levels were also reduced. Moreover, BPE-C decreased body weight by 14.8% and body mass index by 15.9% in BPE-C high group. This correlated with a significant reduction of circulating hormones balancing caloric intake, including leptin, ghrelin and upregulation of adiponectin. All effects showed a dose-dependent tendency. This study suggests that food supplements, containing full spectrum of bergamot juice components, such as BPE-C efficiently induce a combination of weight loss and insulin sensitivity effects together with a robust reduction of atherosclerosis risk. Full article
(This article belongs to the Special Issue Nutrition Status and Atherosclerosis)
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