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The Role of Nutrition in Osteoarthritis Development
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The Role of Nutrition in Osteoarthritis Development

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 25 November 2024 | Viewed by 9604

Special Issue Editor

Dr. Antonia Sophocleous

E-Mail Website
Guest Editor
Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia 2404, Cyprus
Interests: osteoarthritis; cartilage damage; skeletal remodelling; bone metabolism; microbiome; probiotics; prebiotics

Special Issue Information

Dear Colleagues,

Managing osteoarthritis (OA) has become a worldwide challenge. OA is thought to have a multifactorial aetiology, and therefore the underlying cause is incompletely understood. Factors such as mechanical loading, inflammation, metabolic alterations and joint injury play a major role in the pathogenesis of OA. Current medical management is primarily based on trying to control pain, whereas non-pharmacological practices focus on weight loss and physical activity.

Recently, there has been an increasing interest in the potential benefits of diet and nutrition on the prevention and management of OA. Evidence thus far supports the hypothesis that dietary components with anti-inflammatory and antioxidant properties, such as polyunsaturated fatty acids and vitamins C and E, may benefit OA. However, clinically meaningful long-term effects of different nutrients on OA remain to be determined. Any new research on these topics should cast new light on nutrition and its relationship with OA pathogenesis, and have the potential to pave the way for new forms of therapy based on dietary manipulation.

This Special Issue of Nutrients entitled “The Role of Nutrition in Osteoarthritis Development” welcomes original clinical and pre-clinical research studies as well as review articles examining the impact of nutrition on OA. Systematic review and meta-analysis contributions summarizing the current evidence on nutrition and OA interaction are also welcome in this effort.

Dr. Antonia Sophocleous
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoarthritis
  • obesity-associated osteoarthritis
  • inflammation
  • nutrition
  • micronutrients
  • antioxidants
  • polyunsaturated fatty acids
  • vitamins
  • gut microbiome

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Published Papers (5 papers)

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Editorial

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4 pages, 230 KiB  
Editorial
The Role of Nutrition in Osteoarthritis Development
by Antonia Sophocleous
Nutrients 2023, 15(20), 4336; https://doi.org/10.3390/nu15204336 - 12 Oct 2023
Cited by 2 | Viewed by 2827
Abstract
Osteoarthritis (OA) prevalence has increased 113% since 1990, and currently more than half a billion people worldwide are living with this slowly progressing, degenerative joint disease [...] Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)

Research

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20 pages, 2902 KiB  
Article
Exploring the Efficacy of Alpha-Lipoic Acid in Comorbid Osteoarthritis and Type 2 Diabetes Mellitus
by Iryna Halabitska, Valentyn Oksenych and Oleksandr Kamyshnyi
Nutrients 2024, 16(19), 3349; https://doi.org/10.3390/nu16193349 - 2 Oct 2024
Viewed by 652
Abstract
Background/Objectives. The comorbidity of osteoarthritis and type 2 diabetes mellitus poses a complex clinical challenge, complicating patient management due to overlapping pathophysiological mechanisms. This research aims to analyze the exacerbation of clinical symptoms and biochemical markers in patients with OA and T2DM compared [...] Read more.
Background/Objectives. The comorbidity of osteoarthritis and type 2 diabetes mellitus poses a complex clinical challenge, complicating patient management due to overlapping pathophysiological mechanisms. This research aims to analyze the exacerbation of clinical symptoms and biochemical markers in patients with OA and T2DM compared to those with OA alone. Methods. We employed various assessment methods to evaluate inflammation, oxidative stress, and glycemic control in both cohorts. This study includes the administration of alpha-lipoic acid (ALA) to patients with comorbid OA and T2DM, monitoring its effects on joint function, inflammatory markers, oxidative stress levels, and glycemic control. Results. The findings indicate that T2DM significantly worsens clinical symptoms and biochemical markers in OA patients. Those with both conditions exhibited elevated indicators of inflammation and oxidative stress compared to OA-only patients. Additionally, correlations among metabolic, psychological, and inflammatory factors were identified. Body mass index emerged as a potential predictor for the deterioration of evaluated parameters. The analysis revealed that ALA administration led to statistically significant improvements in WOMAC pain scores, the Lequesne Algofunctional Index, and the AIMS-P compared to the control group. Conclusions. Further research into ALA’s effects on OA progression in patients with comorbidities is essential for developing personalized treatment approaches. Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)
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14 pages, 2051 KiB  
Article
S-Equol Ameliorates Menopausal Osteoarthritis in Rats through Reducing Oxidative Stress and Cartilage Degradation
by Yu-Chen Hu, Tzu-Ching Huang, Li-Wen Huang, Hsiao-Ling Cheng, Bau-Shan Hsieh and Kee-Lung Chang
Nutrients 2024, 16(14), 2364; https://doi.org/10.3390/nu16142364 - 21 Jul 2024
Viewed by 1185
Abstract
Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteoporosis in estrogen-deficient mice, but its role in OA remains unknown. [...] Read more.
Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteoporosis in estrogen-deficient mice, but its role in OA remains unknown. This study aimed to explore the effect of S-equol on different degrees of menopausal OA in female Sprague–Dawley (SD) rats induced by estrogen deficiency caused by bilateral ovariectomy (OVX) combined with intra-articular injection of mono-iodoacetate (MIA). Knee joint histopathological change; serum biomarkers of bone turnover, including N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (CTX-I) and N-terminal telopeptide of type I collagen (NTX-I); the cartilage degradation biomarkers hyaluronic acid (HA) and N-terminal propeptide of type II procollagen (PIINP); and the matrix-degrading enzymes matrix metalloproteinases (MMP)-1, MMP-3 and MMP-13, as well as the oxidative stress-inducing molecules nitric oxide (NO) and hydrogen peroxide (H2O2), were assessed for evaluation of OA progression after S-equol supplementation for 8 weeks. The results showed that OVX without or with MIA injection induced various severity levels of menopausal OA by increasing pathological damage, oxidative stress, and cartilage matrix degradation to various degrees. Moreover, S-equol supplementation could significantly reduce these increased biomarkers in different severity levels of OA. This indicates that S-equol can lessen menopausal OA progression by reducing oxidative stress and the matrix-degrading enzymes involved in cartilage degradation. Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)
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Other

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14 pages, 1893 KiB  
Systematic Review
Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis
by Ana María García-Muñoz, María Salud Abellán-Ruiz, Ana Isabel García-Guillén and Desirée Victoria-Montesinos
Nutrients 2024, 16(16), 2640; https://doi.org/10.3390/nu16162640 - 10 Aug 2024
Viewed by 1825
Abstract
Osteoarthritis (OA) is a prevalent, degenerative joint disease, with knee OA being particularly common and impactful. This systematic review and meta-analysis aimed to assess the efficacy of eggshell membrane (ESM) supplementation in improving joint functionality and reducing pain in individuals with knee OA. [...] Read more.
Osteoarthritis (OA) is a prevalent, degenerative joint disease, with knee OA being particularly common and impactful. This systematic review and meta-analysis aimed to assess the efficacy of eggshell membrane (ESM) supplementation in improving joint functionality and reducing pain in individuals with knee OA. A comprehensive search was conducted across PubMed, Scopus, Web of Science, and Cochrane Database up to July 2024, following PRISMA guidelines. Seven randomized controlled trials (RCTs) met the inclusion criteria, with five included in the meta-analysis. The studies compared ESM to a placebo, evaluating outcomes based on assessment tools such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analogue Scale (VAS), and Knee Injury and Osteoarthritis Outcome Score (KOOS). Results indicated that ESM significantly reduced pain and improved functionality, with notable improvements in total WOMAC score (effect size −0.34; 95% CI: −0.56 to −0.13; p < 0.001) and pain subscale (SMD −0.23; 95% CI: −0.42 to −0.04; p < 0.02). The findings support ESM as a promising adjunctive treatment for knee OA, offering a safe, natural supplement to enhance quality of life. Further high-quality RCTs are needed to confirm these results and explore the long-term effects and mechanisms of ESM. Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)
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13 pages, 1379 KiB  
Systematic Review
The Effect of Probiotics on the Management of Pain and Inflammation in Osteoarthritis: A Systematic Review and Meta-Analysis of Clinical Studies
by Maria Moyseos, Jenny Michael, Nuno Ferreira and Antonia Sophocleous
Nutrients 2024, 16(14), 2243; https://doi.org/10.3390/nu16142243 - 12 Jul 2024
Viewed by 2014
Abstract
Osteoarthritis (OA) is one of the most common musculoskeletal disorders. Recently, research has focused on the role of intestinal microbiome dysbiosis in OA. The aim of this study was to systematically review randomized intervention clinical studies investigating the effect of probiotics on the [...] Read more.
Osteoarthritis (OA) is one of the most common musculoskeletal disorders. Recently, research has focused on the role of intestinal microbiome dysbiosis in OA. The aim of this study was to systematically review randomized intervention clinical studies investigating the effect of probiotics on the management of OA-related pain and inflammation. Pre-clinical studies and non-randomized trials were excluded. A literature search was conducted using MEDLINE, EMBASE, and Web of Science. Study quality was assessed with the Cochrane risk of bias (RoB2) tool and the Risk of Bias in N-of-1 Trials (RoBiNT) scale. RevMan was used for the meta-analysis. Outcome measures assessed self-reported pain, stiffness and impediment, and serum hs-CRP. Three studies, with 501 participants, were considered eligible for qualitative synthesis and meta-analysis. A significant reduction in symptoms across all outcomes measured, except stiffness, was evident with Lactobacillus casei Shirota. However, all other probiotics reviewed did not seem to have any effect on the measured outcomes. Pre-clinical evidence, along with the RCTs reviewed, suggests that probiotics of the Lactobacillus strains might be of use for managing pain and inflammation in OA. Considering the small number of studies included in the present review and the possible risk of bias, we conclude that further studies on the role of probiotics in humans with OA are warranted. Full article
(This article belongs to the Special Issue The Role of Nutrition in Osteoarthritis Development)
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