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Global Perspectives on Vitamin D
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Global Perspectives on Vitamin D

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (9 August 2023) | Viewed by 33572

Special Issue Editor

Dr. Peter Frost

E-Mail Website1 Website2
Guest Editor
Anthropology, Université Laval, Quebec City, QC G1V 0A6, Canada
Interests: evolution of human hair, eye, and skin color; gene–culture coevolution; recent cognitive evolution; vitamin D metabolism in Inuit and other Arctic peoples

Special Issue Information

Dear Colleagues,

This special issue, “Global Perspectives on Vitamin D”, will focus on the consequences of having too little or too much vitamin D, not only for the metabolism of calcium and phosphorus (i.e., rickets, osteomalacia, osteoporosis) but also for the regulation of normal development (i.e., cancer, immune malfunctioning, premature aging).

Authors will be encouraged to adopt a global, species-wide perspective. How has vitamin D metabolism adapted to different levels of UVB, different levels of skin pigmentation, different levels of vitamin D in the diet, and different levels of vitamin D in the blood? What forms have these adaptations taken in different human populations? To date, most research has involved fair-skinned participants from Europe or North America, with the result that vitamin D standards may not be appropriate for the majority of people in the world, particularly those who have darker skin or who live at higher latitudes. In particular, such people may develop hypervitaminosis because of the growing popularity of vitamin D supplements.

This Special Issue will provide a new perspective by placing vitamin D within a broader context that may vary not only from one individual to another but also from one population to another.

Dr. Peter Frost
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • diet
  • hypervitaminosis
  • osteomalacia
  • osteoporosis
  • rickets
  • skin pigmentation
  • UVB
  • vitamin D

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Published Papers (4 papers)

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Research

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14 pages, 1935 KiB  
Article
Long-Term Prognosis in Relation to Vitamin D Status in Pediatric Solid Tumor Patients
by Nóra Kárász, Orsolya Juhász, Marcell Imrei and Miklós Garami
Nutrients 2023, 15(21), 4571; https://doi.org/10.3390/nu15214571 - 27 Oct 2023
Viewed by 1917
Abstract
Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a [...] Read more.
Background: Hypovitaminosis D is associated with oncogenesis, and the initial level of Vitamin D may play a role in determining long-term prognosis, relapse-free survival (RFS) and overall survival (OS). The purpose of our study was to follow up pediatric cancer patients for a long time in terms of their baseline Vitamin D level and disease outcomes. Methods: We collected data on the initial 25(OH)D concentration in 117 children and examined their RFS and OS using Kaplan–Meier curves. Results: The initial 25(OH)D mean value in the relapsed group was 20.35 ng/mL (SE: 2.05) and in children without relapse it was 26.14 ng/mL (SE: 1.13). Both the relapse-free and overall Kaplan–Meier curves showed a tendency for children with lower serum Vitamin D concentrations to experience cancer recurrence or fatal outcomes sooner than patients with normal serum levels. Conclusions: Our results indicated a possible correlation between higher pretreatment serum Vitamin D concentrations and improved overall and relapse-free survival. Full article
(This article belongs to the Special Issue Global Perspectives on Vitamin D)
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16 pages, 1786 KiB  
Article
Beneficial Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease (NAFLD) Progression in the Zebrafish Model
by Lihi Grinberg, Fadwa Dabbah Assadi, Gideon Baum, Romy Zemel, Ran Tur-Kaspa, Chen Shochat, David Karasik and Marcela V. Karpuj
Nutrients 2023, 15(6), 1362; https://doi.org/10.3390/nu15061362 - 10 Mar 2023
Cited by 3 | Viewed by 2911
Abstract
A major cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) results from excessive liver fat accumulation. Vitamin D (VitD) plays multiple important roles in diverse physiologic processes. Here, we describe the role of VitD in the complex [...] Read more.
A major cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma, non-alcoholic fatty liver disease (NAFLD) results from excessive liver fat accumulation. Vitamin D (VitD) plays multiple important roles in diverse physiologic processes. Here, we describe the role of VitD in the complex pathogenesis of NAFLD and explore the possible therapeutic role of VitD supplementation in NAFLD therapy. To compare the effect of VitD to other interventions such as low-calorie diet, we induced NAFLD in young adult zebrafish (Danio rerio, AB strain) and monitored the effects of VitD supplementation on the disease course. The zebrafish administered with high-dose VitD (1.25 μg) had significantly reduced liver fat compared to those that received low-dose VitD (0.049 μg) or caloric restriction. Gene expression analysis revealed that VitD downregulated several pathways that may play a role in NAFLD etiology, which affected fatty acid metabolism, vitamins and their cofactors, ethanol oxidation, and glycolysis. The pathway analysis revealed that the cholesterol biosynthesis pathway and the isoprenoid biosynthetic process pathway were significantly upregulated whereas the small molecule catabolic process pathway significantly downregulated following the exposure of NAFLD zebrafish model to high VitD dose. Therefore, our findings suggest the association of novel biochemical pathways with NAFLD and highlight the potential of VitD supplementation to reverse the severity of NAFLD, especially in younger people. Full article
(This article belongs to the Special Issue Global Perspectives on Vitamin D)
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Review

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16 pages, 1173 KiB  
Review
Vitamin D and Its Role on the Fatigue Mitigation: A Narrative Review
by Ippolita Valentina Di Molfetta, Laura Bordoni, Rosita Gabbianelli, Gianni Sagratini and Laura Alessandroni
Nutrients 2024, 16(2), 221; https://doi.org/10.3390/nu16020221 - 10 Jan 2024
Cited by 3 | Viewed by 23417
Abstract
Vitamin D has historically been associated with bone metabolism. However, over the years, a growing body of evidence has emerged indicating its involvement in various physiological processes that may influence the onset of numerous pathologies (cardiovascular and neurodegenerative diseases, rheumatological diseases, fertility, cancer, [...] Read more.
Vitamin D has historically been associated with bone metabolism. However, over the years, a growing body of evidence has emerged indicating its involvement in various physiological processes that may influence the onset of numerous pathologies (cardiovascular and neurodegenerative diseases, rheumatological diseases, fertility, cancer, diabetes, or a condition of fatigue). This narrative review investigates the current knowledge of the pathophysiological mechanisms underlying fatigue and the ways in which vitamin D is implicated in these processes. Scientific studies in the databases of PubMed, Scopus, and Web of Science were reviewed with a focus on factors that play a role in the genesis of fatigue, where the influence of vitamin D has been clearly demonstrated. The pathogenic factors of fatigue influenced by vitamin D are related to biochemical factors connected to oxidative stress and inflammatory cytokines. A role in the control of the neurotransmitters dopamine and serotonin has also been demonstrated: an imbalance in the relationship between these two neurotransmitters is linked to the genesis of fatigue. Furthermore, vitamin D is implicated in the control of voltage-gated calcium and chloride channels. Although it has been demonstrated that hypovitaminosis D is associated with numerous pathological conditions, current data on the outcomes of correcting hypovitaminosis D are conflicting. This suggests that, despite the significant involvement of vitamin D in regulating mechanisms governing fatigue, other factors could also play a role. Full article
(This article belongs to the Special Issue Global Perspectives on Vitamin D)
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16 pages, 1489 KiB  
Review
Therapeutic Effects of Vitamin D on Vaginal, Sexual, and Urological Functions in Postmenopausal Women
by Mohammed M. Hassanein, Hasniza Zaman Huri, Abduelmula R. Abduelkarem and Kauser Baig
Nutrients 2023, 15(17), 3804; https://doi.org/10.3390/nu15173804 - 30 Aug 2023
Cited by 2 | Viewed by 4582
Abstract
Recent years have witnessed the emergence of growing evidence concerning vitamin D’s potential role in women’s health, specifically in postmenopausal women. This evidence also includes its connection to various genitourinary disorders and symptoms. Numerous clinical studies have observed improvements in vulvovaginal symptoms linked [...] Read more.
Recent years have witnessed the emergence of growing evidence concerning vitamin D’s potential role in women’s health, specifically in postmenopausal women. This evidence also includes its connection to various genitourinary disorders and symptoms. Numerous clinical studies have observed improvements in vulvovaginal symptoms linked to the genitourinary syndrome of menopause (GSM) with vitamin D supplementation. These studies have reported positive effects on various aspects, such as vaginal pH, dryness, sexual functioning, reduced libido, and decreased urinary tract infections. Many mechanisms underlying these pharmacological effects have since been proposed. Vitamin D receptors (VDRs) have been identified as a major contributor to its effects. It is now well known that VDRs are expressed in the superficial layers of the urogenital organs. Additionally, vitamin D plays a crucial role in supporting immune function and modulating the body’s defense mechanisms. However, the characterization of these effects requires more investigation. Reviewing existing evidence regarding vitamin D’s impact on postmenopausal women’s vaginal, sexual, and urological health is the purpose of this article. As research in this area continues, there is a potential for vitamin D to support women’s urogenital and sexual health during the menopausal transition and postmenopausal periods. Full article
(This article belongs to the Special Issue Global Perspectives on Vitamin D)
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