New Advances and Applications of Cryogels in Drug Delivery and Regenerative Medicine

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 269

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Department of Drug Chemistry and Technologies, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: drug delivery; hydrogels; polysaccharides; composite systems; rheomechanical properties; micro- and nanoparticulatex delivery systems
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Dipartimento di Ingegneria Chimica, Materiali e Ambiente, Sapienza Università di Roma, Via Eudossiana 18, 00184 Roma, Italy
Interests: transport in porous media; drug release; dispersion theory; chromatography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cryogels have emerged as pivotal tools in drug delivery and regenerative medicine. Their unique interconnected macroporous structure allows for efficient nutrient and oxygen diffusion, making them ideal for tissue engineering applications. In drug delivery, cryogels offer controlled and sustained release of therapeutic agents, improving efficacy and reducing side effects. Recent advances have enhanced their mechanical strength and biocompatibility, expanding their use in various medical fields. Innovations in cryogel technology include the development of smart cryogels that respond to environmental stimuli, such as pH or temperature changes, enabling targeted and on-demand drug release. Furthermore, cryogels are being utilized in the creation of scaffolds for regenerative medicine, promoting cell growth and tissue repair. These advances highlight the significant potential of cryogels in revolutionizing treatment strategies and improving patient outcomes in both drug delivery and regenerative medicine. Modeling and computational research are also welcome. 

Prof. Dr. Patrizia Paolicelli
Prof. Dr. Alessandra Adrover
Guest Editors

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Keywords

  • cryogels
  • drug delivery
  • regenerative medicine
  • tissue engineering
  • controlled release
  • modeling and computation

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Published Papers (1 paper)

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Research

16 pages, 9944 KiB  
Article
Experimental and Modelling Study of Controlled Release from Dextran-Based Cryogels
by Carolina Lauriola, Laura Di Muzio, Patrizia Paolicelli, Maria Antonietta Casadei, Claudia Sergi, Jacopo Tirillò, Vito Cosimo Carriero and Alessandra Adrover
Pharmaceutics 2024, 16(10), 1256; https://doi.org/10.3390/pharmaceutics16101256 - 27 Sep 2024
Abstract
In this work, five different dextran-based cryogels for controlled drug release are investigated. Vitamin B12 was used as a model drug for in vitro release tests. Two different drug-loading procedures were adopted, leading to very different drug release curves. Indeed, a fast Fickian [...] Read more.
In this work, five different dextran-based cryogels for controlled drug release are investigated. Vitamin B12 was used as a model drug for in vitro release tests. Two different drug-loading procedures were adopted, leading to very different drug release curves. Indeed, a fast Fickian release was observed when freeze-dried samples of DEX40PEG360MA and DEX40PEG500MA were infused with the drug after cryogel formation. On the contrary, a slowed highly non-Fickian behavior arises when the drug is loaded before the low-temperature crosslinking step, leading to the cryogel formation. The non-Fickian drug release, observed for all the five different dextran-based cryogels investigated, is actually due to the cryoconcentration phenomenon, modeled with a two-step release process. The proposed transport model accurately predicts experimental release curves characterized by a long lag time, confirming that dextran-based cryogels are suitable for controlled release. Full article
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