Inhalable Drugs for the Treatment of Chronic Respiratory Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1198

Special Issue Editors


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Guest Editor
School of Pharmacy, University of Otago, Dunedin 9054, New Zealand
Interests: nanomedicine; drug formulation; pharmacy and pharmaceutical science
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Pharmacy, University of Otago, Dunedin 9054, New Zealand
Interests: inhalable combination powder

Special Issue Information

Dear Colleagues,

Chronic Respiratory Diseases (CRDs) impose a severe burden on patients and society, and have an increasing rate of mortality and morbidity. Common types of these diseases include asthma, chronic obstructive pulmonary disorder (COPD), cystic fibrosis, lung cancer, and sleep apnea. At present, inhalation therapy is receiving a lot of attention from scientists and researchers. Pulmonary drug delivery is an important method for the administration of treatment and the prevention of diseases of the respiratory tract (nasal and pulmonary regions). It also enables the non-invasive delivery of drugs to the central nervous system (CNS). Pulmonary drug delivery has recently gained significance in the therapeutic field due to its many advantages, such as pain-free administration, targeted drug delivery with minimum systemic exposure, the rapid onset of action, and relatively high local concentrations in the lungs.

Attention is also warranted to various pharmaceutical processes such as milling, mixing, spray drying, amorphisation, micronisation, crystallisation, relaxation, dissolution, coating, and storage. These innovating approaches can be used to develop various conventional and controlled release solid dosage forms, such as powders for respiratory delivery and tablets and capsules for oral delivery.

Prof. Dr. Shyamal Das
Dr. Prakash Khadka
Guest Editors

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Keywords

  • inhalable formulations
  • high-dose formulations
  • aerosolization
  • pulmonary delivery
  • inhalable nanovaccines
  • chronic respiratory diseases

Published Papers (2 papers)

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Research

18 pages, 4196 KiB  
Article
Dry Powder Inhaler Formulation of Lactobacillus rhamnosus GG Targeting Pseudomonas aeruginosa Infection in Bronchiectasis Maintenance Therapy
by The-Thien Tran, Wean Sin Cheow, Siyu Pu, Jin-Won Park and Kunn Hadinoto
Pharmaceutics 2024, 16(8), 980; https://doi.org/10.3390/pharmaceutics16080980 - 25 Jul 2024
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Abstract
The inhaled delivery of lactic acid bacteria (LAB) probiotics has been demonstrated to exert therapeutic benefits to the lungs due to LAB’s immunomodulatory activities. The development of inhaled probiotics formulation, however, is in its nascent stage limited to nebulized LAB. We developed a [...] Read more.
The inhaled delivery of lactic acid bacteria (LAB) probiotics has been demonstrated to exert therapeutic benefits to the lungs due to LAB’s immunomodulatory activities. The development of inhaled probiotics formulation, however, is in its nascent stage limited to nebulized LAB. We developed a dry powder inhaler (DPI) formulation of lactobacillus rhamnosus GG (LGG) intended for bronchiectasis maintenance therapy by spray freeze drying (SFD). The optimal DPI formulation (i.e., LGG: mannitol: lactose: leucine = 35: 45: 15: 5 wt.%) was determined based on the aerosolization efficiency (86% emitted dose and 26% respirable fraction) and LGG cell viability post-SFD (7 log CFU/mL per mg powder). The optimal DPI formulation was evaluated and compared to lyophilized naked LGG by its (1) adhesion capacity and cytotoxicity to human lung epithelium cells (i.e., A549 and 16HBE14o- cells) as well as its (2) effectiveness in inhibiting the growth and adhesion of Pseudomonas aeruginosa to lung cells. The optimal DPI of LGG exhibited similar non-cytotoxicity and adhesion capacity to lung cells to naked LGG. The DPI of LGG also inhibited the growth and adhesion of P. aeruginosa to the lung cells as effectively as the naked LGG. The present work established the feasibility of delivering the LAB probiotic by the DPI platform without adversely affecting LGG’s anti-pseudomonal activities. Full article
(This article belongs to the Special Issue Inhalable Drugs for the Treatment of Chronic Respiratory Diseases)
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18 pages, 5902 KiB  
Article
A Novel Inhalable Dry Powder to Trigger Delivery of Voriconazole for Effective Management of Pulmonary Aspergillosis
by Alanood S. Almurshedi, Sarah N. Almarshad, Sarah I. Bukhari, Basmah N. Aldosari, Samiah A. Alhabardi, Fai A. Alkathiri, Imran Saleem, Noura S. Aldosar and Randa Mohammed Zaki
Pharmaceutics 2024, 16(7), 897; https://doi.org/10.3390/pharmaceutics16070897 - 4 Jul 2024
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Abstract
Invasive pulmonary aspergillosis (IPA) is a fatal fungal infection with a high mortality rate. Voriconazole (VCZ) is considered a first-line therapy for IPA and shows efficacy in patients for whom other antifungal treatments have been unsuccessful. The objective of this study was to [...] Read more.
Invasive pulmonary aspergillosis (IPA) is a fatal fungal infection with a high mortality rate. Voriconazole (VCZ) is considered a first-line therapy for IPA and shows efficacy in patients for whom other antifungal treatments have been unsuccessful. The objective of this study was to develop a high-potency VCZ-loaded liposomal system in the form of a dry-powder inhaler (DPI) using the spray-drying technique to convert liposomes into a nanocomposite microparticle (NCMP) DPI, formulated using a thin-film hydration technique. The physicochemical properties, including size, morphology, entrapment efficiency, and loading efficiency, of the formulated liposomes were evaluated. The NCMPs were then examined to determine their drug content, production yield, and aerodynamic size. The L3NCMP was formulated using a 1:1 lipid/L-leucine ratio and was selected for in vitro studies of cell viability, antifungal activity, and stability. These formulated inhalable particles offer a promising approach to the effective management of IPA. Full article
(This article belongs to the Special Issue Inhalable Drugs for the Treatment of Chronic Respiratory Diseases)
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