Formulation Design of Lipid Nanoparticles for Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1767

Special Issue Editors


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Guest Editor
School of Pharmacy, University of Otago, Dunedin 9054, New Zealand
Interests: nanomedicine; drug formulation; pharmacy and pharmaceutical science
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Chemical and Biomolecular Engineering, Faculty of Engineering, University of Sydney, Camperdown 2006, Australia
Interests: nanoparticles; nanocomposite; nanomedicine; drug delivery

Special Issue Information

Dear Colleagues,

Designing therapeutic payloads to deliver drug molecules to the targeted site is challenging, and lipid nanoparticles have gained substantial interest in preclinical and clinical studies, leveraging their potential outcomes in drug delivery over the last decades. Despite the few commercial successes of lipid nanoparticle technology in vaccines and drug therapeutics, their design, development and quality control studies in large-scale manufacturing have remained both complex and quandary due to a lack of robust and scalable synthesis techniques. It is crucial to understand the role of lipids in drug-loaded nanoparticle stability, bioavailability, safety and efficacy. This Special Issue aims to focus on the different types of lipids as delivery vectors and rationalize the current strategy of nanoparticle design and breakthroughs in their research. In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Prof. Dr. Shyamal Das
Dr. Mahbub Hassan
Guest Editors

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Keywords

  • lipid nanoparticles
  • drug delivery
  • formulation
  • stability
  • controlled release
  • regulatory challenges
  • quality control

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Published Papers (1 paper)

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Review

32 pages, 1685 KiB  
Review
Enhancing Acute Migraine Treatment: Exploring Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for the Nose-to-Brain Route
by Joana Torres, Renata Silva, Gonçalo Farias, José Manuel Sousa Lobo, Domingos Carvalho Ferreira and Ana Catarina Silva
Pharmaceutics 2024, 16(10), 1297; https://doi.org/10.3390/pharmaceutics16101297 - 4 Oct 2024
Viewed by 1295
Abstract
Migraine has a high prevalence worldwide and is one of the main disabling neurological diseases in individuals under the age of 50. In general, treatment includes the use of oral analgesics or non-steroidal anti-inflammatory drugs (NSAIDs) for mild attacks, and, for moderate or [...] Read more.
Migraine has a high prevalence worldwide and is one of the main disabling neurological diseases in individuals under the age of 50. In general, treatment includes the use of oral analgesics or non-steroidal anti-inflammatory drugs (NSAIDs) for mild attacks, and, for moderate or severe attacks, triptans or 5-HT1B/1D receptor agonists. However, the administration of antimigraine drugs in conventional oral pharmaceutical dosage forms is a challenge, since many molecules have difficulty crossing the blood-brain barrier (BBB) to reach the brain, which leads to bioavailability problems. Efforts have been made to find alternative delivery systems and/or routes for antimigraine drugs. In vivo studies have shown that it is possible to administer drugs directly into the brain via the intranasal (IN) or the nose-to-brain route, thus avoiding the need for the molecules to cross the BBB. In this field, the use of lipid nanoparticles, in particular solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), has shown promising results, since they have several advantages for drugs administered via the IN route, including increased absorption and reduced enzymatic degradation, improving bioavailability. Furthermore, SLN and NLC are capable of co-encapsulating drugs, promoting their simultaneous delivery to the site of therapeutic action, which can be a promising approach for the acute migraine treatment. This review highlights the potential of using SLN and NLC to improve the treatment of acute migraine via the nose-to-brain route. First sections describe the pathophysiology and the currently available pharmacological treatment for acute migraine, followed by an outline of the mechanisms underlying the nose-to-brain route. Afterwards, the main features of SLN and NLC and the most recent in vivo studies investigating the use of these nanoparticles for the treatment of acute migraine are presented. Full article
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