Mechanisms of Drug Interactions: Pharmacodynamics and Pharmacokinetics
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 29
Special Issue Editors
Interests: bioanalysis; HPLC-MS/MS technique; method validation; pharmacokinetics; pharmacogenetics
Special Issues, Collections and Topics in MDPI journals
Interests: pharmacokinetics; drug-drug interaction; tyrosine kinase inhibitor; blood-brain barrier; zebrafish
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug interactions occur when a change in drug activity is observed, and can be pharmacokinetic (PK) or pharmacodynamic (PD). In addition, we observe drug–drug, drug–dietary supplement, drug–disease, drug–microbiome, and drug–food interactions. Pharmacokinetic interactions occur when one drug alters another drug's absorption, distribution, metabolism, or excretion. This type of reaction can vary between patients and requires individual management. Pharmacodynamic interactions occur between drugs with similar or opposite pharmacological effects. The underlying mechanisms involve competition at molecular or cellular sites of action, and the effects are generally common to related drugs. The occurrence of interactions between the drugs a patient takes can have an adverse effect on the action of the drugs and the patient's health. Treatment is not effective if the effect of the drugs is weakened and/or their action modified. On the other hand, an increase in the plasma concentration of a therapeutic substance and its prolonged residence in the human body can lead to adverse effects specific to the drug, but with greater intensity and a greater probability. Such effects can be dangerous to the patient's health or even life-threatening.
This Special Issue welcomes studies on the mechanisms underlying drug interactions, their clinical and economic significance, and practical, evidence-based options for the safe and effective management of the consequences of drug interactions.
Prof. Dr. Marta Karaźniewicz-Łada
Dr. Agnieszka Karbownik
Dr. Danuta Szkutnik-Fiedler
Guest Editors
Manuscript Submission Information
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Keywords
- drug interactions
- pharmacokinetics
- pharmacodynamics
- ADME
