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Pharmaceutics
Special Issues
Excipients for Direct Compaction
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Excipients for Direct Compaction

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 3725

Special Issue Editors

Dr. Ann-Sofie Persson

E-Mail Website
Guest Editor
Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden
Interests: powder compression; powder compaction; tabletting; mechanical analysis; particle analysis; granulation
Dr. Josefina Nordström

E-Mail Website
Guest Editor
Department of Pharmaceutical Biosciences, Uppsala University, Box 591, SE-751 24 Uppsala, Sweden
Interests: powder compression; powder compaction; granulation; particle structure; powder properties; tabletting

Special Issue Information

Dear Colleagues,

Tablets have long been, and still remain, the first-hand choice for administrating medicines. Regarding tablet manufacturing, direct compaction of powder formulations is preferred compared to granulation prior to compaction. However, direct compaction of powders sets high demands on the technical properties of the powder blend in order to ensure that the manufactured tablets meet the product requirements. As the predominant fraction of a tablet typically consists of excipients, the suitability of a powder formulation for direct compaction is mainly governed by the properties of the excipients. This Special Issue aims to highlight new approaches to direct compaction of powders using either traditional or novel excipients in addition to the excipient properties critical for the manufacturing performance of the powder.

We are pleased to invite you to contribute your research in this interesting field to the Special Issue on “Excipients for Direct Compaction”, and we welcome original research articles, communications, and reviews.

We look forward to receiving your contributions.

Dr. Ann-Sofie Persson
Dr. Josefina Nordström
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • powders
  • excipients
  • compaction
  • compression
  • tablets
  • flowability
  • mechanical properties
  • tablet tensile strength
  • compactibility
  • tabletability

Published Papers (1 paper)

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Research

17 pages, 4257 KiB  
Article
The Effect of Particle Shape on the Compaction of Realistic Non-Spherical Particles—A Multi-Contact DEM Study
by Kostas Giannis, Arno Kwade, Jan Henrik Finke and Carsten Schilde
Pharmaceutics 2023, 15(3), 909; https://doi.org/10.3390/pharmaceutics15030909 - 10 Mar 2023
Cited by 4 | Viewed by 3185
Abstract
The purpose of this study was to investigate the deformation behavior of non-spherical particles during high-load compaction using the multi-contact discrete element method (MC-DEM). To account for non-spherical particles, the bonded multi-sphere method (BMS), which incorporates intragranular bonds between particles, and the conventional [...] Read more.
The purpose of this study was to investigate the deformation behavior of non-spherical particles during high-load compaction using the multi-contact discrete element method (MC-DEM). To account for non-spherical particles, the bonded multi-sphere method (BMS), which incorporates intragranular bonds between particles, and the conventional multi-sphere (CMS), where overlaps between particles are allowed to form a rigid body, were used. Several test cases were performed to justify the conclusions of this study. The bonded multi-sphere method was first employed to study the compression of a single rubber sphere. This method’s ability to naturally handle large elastic deformations is demonstrated by its agreement with experimental data. This result was validated further through detailed finite element simulations (multiple particle finite element method (MPFEM)). Furthermore, the conventional multi-sphere (CMS) approach, in which overlaps between particles are allowed to form a rigid body, was used for the same objective, and revealed the limitations of this method in successfully capturing the compression behavior of a single rubber sphere. Finally, the uniaxial compaction of a microcrystalline cellulose-grade material, Avicel® PH 200 (FMC BioPolymer, Philadelphia, PA, USA), subjected to high confining conditions was studied using the BMS method. A series of simulation results was obtained with realistic non-spherical particles and compared with the experimental data. For a system composed of non-spherical particles, the multi-contact DEM showed very good agreement with experimental data. Full article
(This article belongs to the Special Issue Excipients for Direct Compaction)
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