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Pharmaceutics
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3D-Printed Solid Pharmaceutical Formulations: Physicochemical Properties and Modified Release (Volume...
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3D-Printed Solid Pharmaceutical Formulations: Physicochemical Properties and Modified Release (Volume II)

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 6344

Special Issue Editors

Dr. Marilena Vlachou

E-Mail Website1 Website2
Guest Editor
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece
Interests: drug carriers; drug delivery; biopolymers; nanotechnology; nanomaterials
Special Issues, Collections and Topics in MDPI journals
Dr. Angeliki Siamidi

E-Mail Website
Guest Editor
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece
Interests: drug delivery; controlled release; modified release; statistical analysis; melatonin; tablet; formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, 3D printing (3DP), especially towards the production of personalized solid oral formulations, has attracted the vivid interest of academia, the chemical industry and pharma. However, commercially available 3D printers are limited with regard to the materials that can be processed—only a few types of thermoplastic polymers are suitable, and these may often not be pharmaceutically approved biomaterials and/or ideal for optimizing the dosage form performance of poorly water-soluble active substances. In this special section of Pharmaceutics, articles that bring a new insight into the design principles of controlled release formulations using 3DP technology are hosted. The manuscripts presented herein report the interplay of the miscibility between excipients in the blends, the solubility of the bioactive substances in the aqueous dissolution media and the nature/stereoelectronic features of the biopolymers used to manipulate the drug release rate of the dispersions.

Dr. Marilena Vlachou
Dr. Angeliki Siamidi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • three-dimensional printing solid dispersions
  • poorly water-soluble drugs
  • polymer blends
  • modified release

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Related Special Issue

Published Papers (3 papers)

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Research

13 pages, 3110 KiB  
Article
In Vitro Profile of Hydrocortisone Release from Three-Dimensionally Printed Paediatric Mini-Tablets
by Chrystalla Protopapa, Angeliki Siamidi, Siva Satyanarayana Kolipaka, Laura Andrade Junqueira, Dennis Douroumis and Marilena Vlachou
Pharmaceutics 2024, 16(3), 385; https://doi.org/10.3390/pharmaceutics16030385 - 11 Mar 2024
Cited by 2 | Viewed by 1500
Abstract
Three-dimensional (3D) printing is quickly being adopted in pharmaceutics due to the many advantages it offers, including treatment, adaptability, the reduction in waste and the accelerated development of new formulations. In this study, micro-extrusion printing was implemented for the production of modified-release hydrocortisone [...] Read more.
Three-dimensional (3D) printing is quickly being adopted in pharmaceutics due to the many advantages it offers, including treatment, adaptability, the reduction in waste and the accelerated development of new formulations. In this study, micro-extrusion printing was implemented for the production of modified-release hydrocortisone (HCT) mini-tablets for paediatric patients. For the developed formulations, Gelucire® 44/14 and Precirol® ATO 5 were used as the main inks at three different ratios: 70%/30%, 60%/40% and 50%/50%, respectively. The printing parameters (temperature and pressure) were altered accordingly for each ratio to achieve printability. The printed mini-tablets exhibited excellent printing quality, featuring consistent layer thicknesses and smooth surfaces. Dissolution tests were performed, and the results indicated a successful modified release of HCT from the mini-tablets. In summary, micro-extrusion exhibited favourable processing abilities for powder blends, facilitating quick printing and the fabrication of potential personalized dosages. Full article
(This article belongs to the Special Issue 3D-Printed Solid Pharmaceutical Formulations: Physicochemical Properties and Modified Release (Volume II))
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13 pages, 3296 KiB  
Article
Production of Bi-Compartmental Tablets by FDM 3D Printing for the Withdrawal of Diazepam
by Joana Macedo, Rita Marques, Chris Vervaet and João F. Pinto
Pharmaceutics 2023, 15(2), 538; https://doi.org/10.3390/pharmaceutics15020538 - 6 Feb 2023
Cited by 9 | Viewed by 2210
Abstract
Diazepam (DZP) is a long-acting benzodiazepine to treat anxiety or acute alcohol withdrawal. Although this class of drugs should be taken for a short period of time, many patients take them for longer than recommended, which has been linked to an increased risk [...] Read more.
Diazepam (DZP) is a long-acting benzodiazepine to treat anxiety or acute alcohol withdrawal. Although this class of drugs should be taken for a short period of time, many patients take them for longer than recommended, which has been linked to an increased risk of dementia and dependence. The present work aimed at using the dual-nozzle system of fused deposition modeling (FDM) 3D printers to prepare tablets with gradual doses of DZP with constant mass and size. Placebo and DZP-loaded filaments were prepared by hot-melt extrusion and used to print the bi-compartmental tablets. Thermal processing allowed the conversion of crystalline DZP to its amorphous counterpart. Tablets with different DZP contents were effectively printed with a mass, thickness and diameter average of 111.6 mg, 3.1 mm, and 6.4 mm, respectively. Microscopic data showed good adhesion between the different layers in the printed tablets. The desired drug contents were successfully achieved and were within the acceptance criteria (European Pharmacopeia). The combination of a placebo and drug-loaded extrudates proved to be beneficial in the production of tablets by FDM for patients in need of drug withdrawal. Full article
(This article belongs to the Special Issue 3D-Printed Solid Pharmaceutical Formulations: Physicochemical Properties and Modified Release (Volume II))
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13 pages, 2756 KiB  
Article
3D-Printed Fast-Dissolving Oral Dosage Forms via Fused Deposition Modeling Based on Sugar Alcohol and Poly(Vinyl Alcohol)—Preparation, Drug Release Studies and In Vivo Oral Absorption
by Sorato Ikeda, Masanori Kobayashi, Soken Aoki, Takayuki Terukina, Takanori Kanazawa, Hiroyuki Kojima and Hiromu Kondo
Pharmaceutics 2023, 15(2), 395; https://doi.org/10.3390/pharmaceutics15020395 - 24 Jan 2023
Cited by 9 | Viewed by 2175
Abstract
Three-dimensional printing technology holds marked promise for the pharmaceutical industry and is now under intense investigation. Most research is aimed at a greater efficiency in printing oral dosage forms using powder bed printing or fused deposition modeling (FDM). Oral dosage forms printed by [...] Read more.
Three-dimensional printing technology holds marked promise for the pharmaceutical industry and is now under intense investigation. Most research is aimed at a greater efficiency in printing oral dosage forms using powder bed printing or fused deposition modeling (FDM). Oral dosage forms printed by FDM tend to be hard objects, which reduce the risk of cracking and chipping. However, one challenge in printing oral dosage forms via FDM is achieving rapid drug release, because the materials for FDM are basically thermoplastic polymers with slow drug release properties. In this study, we investigated printing a fast-dissolving oral dosage form by adding sugar alcohol to a poly(vinyl alcohol)-based formulation for FDM. Filaments which contain sugar alcohol were successfully prepared, and objects were printed with them as oral dosage forms by FDM. On drug release testing, a printed oral dosage form in a ring shape which contained 55% maltitol showed a more than 85% drug release in 15 min. In vivo oral absorption of this printed oral dosage form in dogs was comparable to that of a conventional fast-dissolving tablet. Of particular interest, the drug release profile and drug amount of the oral dosage forms can be easily controlled by a change in shape using 3D Computer Aided Design. These characteristics will encourage the prevalence of FDM by the pharmaceutical industry, and contribute to the promotion of personalized medicine. Full article
(This article belongs to the Special Issue 3D-Printed Solid Pharmaceutical Formulations: Physicochemical Properties and Modified Release (Volume II))
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