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Pharmaceutics
Special Issues
Biodegradable, Biocompatible Carriers for Drug and Gene Delivery
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Biodegradable, Biocompatible Carriers for Drug and Gene Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 5299

Special Issue Editor

Prof. Dr. Sung Tae Kim

E-Mail Website
Guest Editor
Department of Pharmaceutical Engineering, Inje University, Gimhae 50834, Republic of Korea
Interests: biodegradable polymers; nanostructured drug and gene delivery system; interdisciplinary research of nano/bio; bioactive agents; therapeutics; active targeting
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biodegradable, biocompatible materials have been widely studied as potential carriers for delivering therapeutic drugs and genes owing to their physicochemical properties such as biocompatibility, biodegradability, reduced toxicity, and immunogenicity. These materials can be of natural/biological or synthetic origin, and their remarkable properties offer a variety of advantages, leading to various pharmaceutical applications for designing micro- and nanovehicles of therapeutic drugs and genes. Thus far, the development of these materials has been focused on natural biodegradable polymers, including protein-based polymers, polysaccharides, microbial polymers, and synthetic biodegradable polymers, such as polyesters, polyphosphazenes, polyorthoesters, polyanhydrides, polyalkylcyanoacrylates. Many of them are currently on the market and/or act as candidates for delivery carriers. Furthermore, several materials are still under study for preclinical and clinical applications in the future using new fabrication and manufacturing processes. 

This Special Issue of Pharmaceutics will focus on new approaches of biodegradable, biocompatible carriers/vehicles for drug and gene delivery. Potential topics include, but are not limited to, the design, fabrication, and application of biodegradable, biocompatible carriers for drug and gene delivery. Full-length original research papers, short communications, and reviews are welcomed.

Prof. Dr. Sung Tae Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

14 pages, 2015 KiB  
Article
Polyhydroxyalkanoate Decelerates the Release of Paclitaxel from Poly(lactic-co-glycolic acid) Nanoparticles
by Si Yeong Lee, So Yun Kim, Sook Hee Ku, Eun Ji Park, Dong-Jin Jang, Sung Tae Kim and Seong-Bo Kim
Pharmaceutics 2022, 14(8), 1618; https://doi.org/10.3390/pharmaceutics14081618 - 2 Aug 2022
Cited by 4 | Viewed by 1978
Abstract
Biodegradable nanoparticles (NPs) are preferred as drug carriers because of their effectiveness in encapsulating drugs, ability to control drug release, and low cytotoxicity. Although poly(lactide co-glycolide) (PLGA)-based NPs have been used for controlled release strategies, they have some disadvantages. This study describes an [...] Read more.
Biodegradable nanoparticles (NPs) are preferred as drug carriers because of their effectiveness in encapsulating drugs, ability to control drug release, and low cytotoxicity. Although poly(lactide co-glycolide) (PLGA)-based NPs have been used for controlled release strategies, they have some disadvantages. This study describes an approach using biodegradable polyhydroxyalkanoate (PHA) to overcome these challenges. By varying the amount of PHA, NPs were successfully fabricated by a solvent evaporation method. The size range of the NPS ranged from 137.60 to 186.93 nm, and showed zero-order release kinetics of paclitaxel (PTX) for 7 h, and more sustained release profiles compared with NPs composed of PLGA alone. Increasing the amount of PHA improved the PTX loading efficiency of NPs. Overall, these findings suggest that PHA can be used for designing polymeric nanocarriers, which offer a potential strategy for the development of improved drug delivery systems for sustained and controlled release. Full article
(This article belongs to the Special Issue Biodegradable, Biocompatible Carriers for Drug and Gene Delivery)
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20 pages, 32370 KiB  
Article
Enzyme-Responsive Amphiphilic Peptide Nanoparticles for Biocompatible and Efficient Drug Delivery
by Su Jeong Song and Joon Sig Choi
Pharmaceutics 2022, 14(1), 143; https://doi.org/10.3390/pharmaceutics14010143 - 7 Jan 2022
Cited by 13 | Viewed by 2773
Abstract
Self-assembled peptide nanostructures recently have gained much attention as drug delivery systems. As biomolecules, peptides have enhanced biocompatibility and biodegradability compared to polymer-based carriers. We introduce a peptide nanoparticle system containing arginine, histidine, and an enzyme-responsive core of repeating GLFG oligopeptides. GLFG oligopeptides [...] Read more.
Self-assembled peptide nanostructures recently have gained much attention as drug delivery systems. As biomolecules, peptides have enhanced biocompatibility and biodegradability compared to polymer-based carriers. We introduce a peptide nanoparticle system containing arginine, histidine, and an enzyme-responsive core of repeating GLFG oligopeptides. GLFG oligopeptides exhibit specific sensitivity towards the enzyme cathepsin B that helps effective controlled release of cargo molecules in the cytoplasm. Arginine can induce cell penetration, and histidine facilitates lysosomal escape by its buffering capacity. Herein, we propose an enzyme-responsive amphiphilic peptide delivery system (Arg-His-(Gly-Phe-Lue-Gly)3, RH-(GFLG)3). The self-assembled RH-(GFLG)3 globular nanoparticle structure exhibited a positive charge and formulation stability for 35 days. Nile Red-tagged RH-(GFLG)3 nanoparticles showed good cellular uptake compared to the non-enzyme-responsive control groups with d-form peptides (LD (LRH-D(GFLG)3), DL (DRH-L(GFLG)3), and DD (DRH-D(GFLG)3). The RH-(GFLG)3 nanoparticles showed negligible cytotoxicity in HeLa cells and human RBCs. To determine the drug delivery efficacy, we introduced the anticancer drug doxorubicin (Dox) in the RH-(GFLG)3 nanoparticle system. LL-Dox exhibited formulation stability, maintaining the physical properties of the nanostructure, as well as a robust anticancer effect in HeLa cells compared to DD-Dox. These results indicate that the enzyme-sensitive RH-(GFLG)3 peptide nanoparticles are promising candidates as drug delivery carriers for biomedical applications. Full article
(This article belongs to the Special Issue Biodegradable, Biocompatible Carriers for Drug and Gene Delivery)
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