Relevance of Plant Phytochemicals in the Promotion of Human Health: Second Edition

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1098

Special Issue Editors


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Guest Editor
Escuela Superior de Medicina, Instituto Politécnico Nacional, “Unidad Casco de Santo Tomas”, Ciudad de México 11340, Mexico
Interests: pharmacology; toxicology; chemoprevention
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Guest Editor
Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Institute of Health Sciences, Autonomous University of the State of Hidalgo Ex-Hacienda de la Concepción, Tilcuautla, Pachuca de Soto 42080, Mexico
Interests: natural products; oxidative stress; infertility

Special Issue Information

Dear Colleagues,

A range of evidence has demonstrated that plants perform an important role in the care and improvement of human health. The World Health Organization estimates that more than 80% of the Earth’s inhabitants depend on, or have used, traditional medicine/complementary and alternative medicine (TCAM) for their primary health care needs, conceptualizing TCAM as any practice, piece of knowledge, and belief on health that incorporates medicine based on plants, animals, and/or minerals, as well as spiritual therapies, manual techniques, and exercises applied individually or in combination to maintain wellbeing. Different positive factors generate continuous acceptance, highlighting its diversity, flexibility, easy access, relatively low cost, and most importantly the presence of relatively low adverse toxic effects (which are frequently attributed to synthetic drugs) in comparison with allopathic medicine). An essential part of this beneficial impact is attributed to the presence of phytochemicals or bioactive compounds, classified as terpenoids (carotenoids and sterols), fibers, polysaccharides, saponins, organosulfur compounds (isothiocyanates and indoles), alkaloids, and phenolics compounds (flavonoids, stilbenes, coumarins, tannins, and phenolic acids) that jointly or individually have demonstrated the ability to prevent and/or treat different pathologies, including cardiovascular diseases, obesity, diabetes, neurodegenerative diseases, hypertension, atherosclerosis, chronic respiratory diseases, osteoporosis, and cancer. In recent decades, its popularization and scientific interest has grown, in order to identify new phytochemicals, study their protective and/or therapeutic effects, and establish the mechanisms of action involved (especially those related to their antioxidant capacity). This Special Issue of Plants aims to provide a platform for researchers and academicians to demonstrate their interest in the mentioned fields. Therefore, please accept a cordial invitation to submit original research articles or comprehensive review articles for inclusion in this Special Issue.

Dr. Eduardo Osiris Madrigal-Santillán
Dr. Manuel Sánchez-Gutiérrez
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • plants
  • pharmacology
  • toxicology
  • pharmacognosy
  • natural products
  • phytochemicals
  • chemopreventive mechanisms
  • antioxidant agents
  • oxidative stress
  • toxicological genetics

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Published Papers (1 paper)

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Research

14 pages, 959 KiB  
Article
Evaluation of the Antigenotoxic Potential of Two Types of Chayote (Sechium edule) Juices
by Eduardo Madrigal-Santillán, Jacqueline Portillo-Reyes, José A. Morales-González, Luis F. Garcia-Melo, Estrella Serra-Pérez, Kristijan Vidović, Manuel Sánchez-Gutiérrez, Isela Álvarez-González and Eduardo Madrigal-Bujaidar
Plants 2024, 13(15), 2132; https://doi.org/10.3390/plants13152132 - 1 Aug 2024
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Abstract
Sechium edule (Jacq.) Swartz is a perennial herbaceous climbing plant with tendrils and tuberous roots belonging to the Cucurbitaceae family. Its fruits (“chayote”), stems, roots, and leaves are edible and are commonly ingested by humans. It has shown medicinal properties attributed to its [...] Read more.
Sechium edule (Jacq.) Swartz is a perennial herbaceous climbing plant with tendrils and tuberous roots belonging to the Cucurbitaceae family. Its fruits (“chayote”), stems, roots, and leaves are edible and are commonly ingested by humans. It has shown medicinal properties attributed to its bioactive compounds (vitamins, phenolic acids, flavonoids, carotenoids, triterpenoids, polyphenolic compounds, phytosterols, and cucurbitacins), which together have been associated with the control and prevention of chronic and infectious diseases, highlighting its antibacterial, anti-cardiovascular/antihypertensive, antiepileptic, anti-inflammatory, hepatoprotective, antiproliferative, and antioxidant activities. The objective of the study was to determine the antigenotoxic potential of two types of fresh chayote juice (filtered (FChJ) and unfiltered (UFChJ)) against DNA damage produced by benzo[a]pyrene (B[a]P) using an in vivo mouse peripheral blood micronucleus assay (MN). The juices were consumed freely for 2 weeks. A negative control, a control group of each juice, a positive batch [B[a]P], and two combined batches (B[a]P plus FChJ or UFChJ) were included. Blood smears were stained and observed under a microscope to quantify the number of micronucleated normochromic erythrocytes (MNNEs). The results indicate: (a) B[a]P increased the frequency of MNNEs and reduced the rate of PEs; and (b) no juice produced toxic effects or induced MN. On the contrary, both juices were genoprotective. However, the most significant effect was presented by UFChJ at the end of the experiment (70%). It is suggested that UFChJ has a greater amount of fiber and/or phytochemicals that favor the therapeutic effect. Possibly, the genoprotection is also related to its antioxidant capacity. Full article
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