Parasitology Research: Surveillance Pathogens and Its Mechanism

A special issue of Veterinary Sciences (ISSN 2306-7381).

Deadline for manuscript submissions: closed (1 July 2023) | Viewed by 5911

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Guest Editor
Department of Parasitology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan
Interests: parasitology; basic medicine; molecular pharmacology; drug development
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Special Issue Information

Dear Colleagues,

In recent years, new technologies and concepts in molecular biology, immunology, and genetics have been applied to the study of veterinary parasitology. This leads to a novel and interesting approach to the vaccine and diagnostic tool development, rational drug design, detection and more accurate classification of some parasites, and a more detailed understanding of host-parasite relationships.

This Special Issue provides a platform to exchange research results, expertise, and opinions including but are not limited to:

  • veterinary public health
  • wildlife diseases
  • emerging and exotic infectious diseases
  • surveillance strategies
  • fisheries culture
  • molecular epidemic diseases
  • dietary and biological treatment of infestations
  • animal wellbeing
  • organic farming systems
  • new vaccination strategies
  • drug target characterization and rational drug design

Dr. Rong Jyh Lin
Guest Editor

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Keywords

  • veterinary parasitology
  • molecular biology
  • immunology
  • drug development
  • host–pathogen interactions
  • vaccine development

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Published Papers (2 papers)

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Research

12 pages, 876 KiB  
Article
Immune and Genomic Analysis of Boxer Dog Breed and Its Relationship with Leishmania infantum Infection
by Luis Álvarez, Pablo-Jesús Marín-García, Pilar Rentero-Garrido and Lola Llobat
Vet. Sci. 2022, 9(11), 608; https://doi.org/10.3390/vetsci9110608 - 2 Nov 2022
Cited by 1 | Viewed by 2790
Abstract
Leishmaniosis, one of the most important zoonoses in Europe, is caused by Leishmania infantum, an intracellular protozoan parasite. This disease is endemic in the Mediterranean area, where the main reservoir is the dog. Several studies indicate a possible susceptibility to L. infantum [...] Read more.
Leishmaniosis, one of the most important zoonoses in Europe, is caused by Leishmania infantum, an intracellular protozoan parasite. This disease is endemic in the Mediterranean area, where the main reservoir is the dog. Several studies indicate a possible susceptibility to L. infantum infection with clinical signs in some canine breeds. One of them is the boxer breed, which shows a high prevalence of disease. In this study, immunological and genomic characterization of serum samples from boxer dogs living in the Mediterranean area were evaluated to analyze the immune response and the possible genetic explanation for this susceptibility. Serum levels of cytokines IFN-γ, IL-2, IL-6, IL-8, and IL-18 were determined by ELISA commercial tests, while the genotyping study was performed using the CanineHD DNA Analysis BeadChip. The results show relevant differences in the serum levels of cytokines compared to published data on other canine breeds, as well as sequence changes that could explain the high susceptibility of the boxer breed to the disease. Concretely, polymorphic variants in the CIITA, HSF2BP, LTBP1, MITF, NOXA1, PKIB, RAB38, RASEF, TLE1, and TLR4 genes were found, which could explain the susceptibility of this breed to L. infantum infection. Full article
(This article belongs to the Special Issue Parasitology Research: Surveillance Pathogens and Its Mechanism)
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10 pages, 1389 KiB  
Article
Evaluation of the Acaricidal Effectiveness of Fipronil and Phoxim in Field Populations of Dermanyssus gallinae (De Geer, 1778) from Ornamental Poultry Farms in Italy
by Alessandro Guerrini, Benedetto Morandi, Paola Roncada, Gianfranco Brambilla, Filippo Maria Dini and Roberta Galuppi
Vet. Sci. 2022, 9(9), 486; https://doi.org/10.3390/vetsci9090486 - 8 Sep 2022
Cited by 4 | Viewed by 2453
Abstract
The poultry red mite Dermanyssus gallinae is the most important blood-sucking ectoparasite in egg-laying hen facilities. The aim of this study was to evaluate the in vitro acaricidal activity of different concentration of authorized (phoxim, ByeMite®, 500 mg/mL) and unauthorized (fipronil, [...] Read more.
The poultry red mite Dermanyssus gallinae is the most important blood-sucking ectoparasite in egg-laying hen facilities. The aim of this study was to evaluate the in vitro acaricidal activity of different concentration of authorized (phoxim, ByeMite®, 500 mg/mL) and unauthorized (fipronil, Frontline® 250 mg/100 mL spray) molecules on 14 field isolates of D. gallinae collected from different ornamental poultry farms from different Italian regions. The sensitivity test was performed by contact exposure to four concentrations of each insecticide diluted at 1:5 (10,000-2000-400-80 ppm for phoxim, 500-100-20-4 ppm for fipronil) on a filter paper. The effectiveness of the treatment was significantly (p < 0.0001) associated with the dose of the pesticide used. Considering the mean lethality, phoxim has greater efficacy compared to fipronil (p < 0.001). A great variability of lethality rate was observed with the increase in fipronil dilution; conversely, for phoxim, some outliers were observed, particularly in one farm, suggesting the hypothesis that a certain degree of resistance in the mite population could occur possibly as a consequence of the continual contact with the molecule. This underlines the importance of the use of licensed products administered at correct dosages and the need for alternative molecules to avoid the onset of drug resistance phenomena. Full article
(This article belongs to the Special Issue Parasitology Research: Surveillance Pathogens and Its Mechanism)
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