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Keywords = micro-opto-electro-mechanical system

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15 pages, 10540 KB  
Article
Piezoelectric Thin-Film Actuator for Dynamic Tuning of Micro-Optical Cavities
by Dehua Tan, Pengfei Li, Xuyang Zhou, Qingxiong Xiao, Chaohui Wu, Qixuan Zhu, Miao Lei, Ting Li and Qianbo Lu
Micromachines 2026, 17(3), 345; https://doi.org/10.3390/mi17030345 - 12 Mar 2026
Viewed by 442
Abstract
In micro-opto-electro-mechanical systems (MOEMS), the micro-optical cavity plays a pivotal role. As performance requirements for MOEMS devices continue to rise, these cavities must achieve higher performance levels while simultaneously reducing their physical footprint. However, existing high-precision micro-optical cavities face challenges such as high [...] Read more.
In micro-opto-electro-mechanical systems (MOEMS), the micro-optical cavity plays a pivotal role. As performance requirements for MOEMS devices continue to rise, these cavities must achieve higher performance levels while simultaneously reducing their physical footprint. However, existing high-precision micro-optical cavities face challenges such as high process sensitivity and conflicting trade-offs between dynamic range and precision. To address these issues, piezoelectric thin-film actuators present a viable solution due to their high precision, stroke flexibility, electromagnetic interference resistance, and structural scalability. This study proposes a piezoelectric thin-film actuator based on the d33 mode. The device adopts an island-circular structure that integrates a lead zirconate titanate (PZT) piezoelectric film with metal electrodes. By employing particle swarm optimization (PSO) to enhance displacement output and anti-gravity capabilities, the actuator achieves displacement outputs below 100 nm within a compact form factor while maintaining nanometer-level resolution. Simulation and experimental results confirm a first-order natural frequency of approximately 5.8 kHz, along with a reasonable linear displacement response across a 4–6 V drive voltage range. Furthermore, the device demonstrates functionality within a Fabry–Pérot (F-P) microcavity system, enabling active optical path length modulation through precise cavity tuning. This research provides an effective approach to enhancing the dynamic performance and process compatibility of micro-optical cavity devices, advancing the development of next-generation MOEMS systems. Full article
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17 pages, 4085 KB  
Article
Thermal Sensitivity of a Microoptoelectromechanical Evanescent-Coupling-Based Accelerometer
by Evgenii Barbin, Ivan Kulinich, Tamara Nesterenko, Alexei Koleda, Ayan Myrzakhmetov, Denis Mokhovikov, Sergey Vtorushin and Alena Talovskaia
Sensors 2025, 25(20), 6388; https://doi.org/10.3390/s25206388 - 16 Oct 2025
Viewed by 2844
Abstract
This treatise studies the thermal sensitivity of the mechanical and optical transmission coefficients of a microoptoelectromechanical (MOEM) accelerometer based on evanescent coupling in a temperature range from minus 40 to plus 125 °C. Two types of optical measuring transducers are considered: based on [...] Read more.
This treatise studies the thermal sensitivity of the mechanical and optical transmission coefficients of a microoptoelectromechanical (MOEM) accelerometer based on evanescent coupling in a temperature range from minus 40 to plus 125 °C. Two types of optical measuring transducers are considered: based on a directional coupler and a resonator. This analysis covers the optical and mechanical components of the thermal sensitivity of the transmission coefficient. In terms of the mechanical part, the temperature effect induces changes to the linear dimensions of the structure and material characteristics and causes internal mechanical stresses as well. The temperature effect on the optical system of the accelerometer is conditioned by the thermo-optic effect of the materials the optical waveguides are made of. This study includes experiments on the refraction index dependence on the temperature of the optical films that compose the optical system of the MOEM accelerometer. The experiment shows that the refraction index of the films grows with temperature and amounts to 0.12642 ppm/°C for silicon nitride on the SiO2/Si substrate. For the optical measuring transducer based on a directional coupler, the thermal sensitivity of the accelerometer’s optical transmission coefficient is 580 ppm/°C. For the resonator-based transducer, the thermal sensitivity is 0.33 °C−1. The thermal sensitivity of the normalized mechanical transmission coefficient of the accelerometer is 120 ppm/°C. For optical measuring transducers based on a directional coupler, the contribution of the temperature dependent refraction index alteration to the overall error is 5 times larger than that of the MOEM accelerometer’s mechanical parameters, while for the resonator-based transducer the difference reaches 3000 times. This means its operability is only possible in a thermostatic environment. Full article
(This article belongs to the Special Issue Advanced Optical and Optomechanical Sensors)
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9 pages, 3584 KB  
Article
Parameter Study of 500 nm Thick Slot-Type Photonic Crystal Cavities for Cavity Optomechanical Sensing
by Zhe Li, Jun Liu, Yi Zhang, Chenguwei Xian, Yifan Wang, Kai Chen, Gen Qiu, Guangwei Deng, Yongjun Huang and Boyu Fan
Photonics 2025, 12(6), 584; https://doi.org/10.3390/photonics12060584 - 8 Jun 2025
Cited by 1 | Viewed by 3496
Abstract
In recent years, research on light-matter interactions in silicon-based micro/nano cavity optomechanical systems demonstrates high-resolution sensing capabilities (e.g., sub-fm-level displacement sensitivity). Conventional 2D photonic crystal (PhC) cavity optomechanical sensors face inherent limitations: thin silicon layers (200–300 nm) restrict both the mass block (critical [...] Read more.
In recent years, research on light-matter interactions in silicon-based micro/nano cavity optomechanical systems demonstrates high-resolution sensing capabilities (e.g., sub-fm-level displacement sensitivity). Conventional 2D photonic crystal (PhC) cavity optomechanical sensors face inherent limitations: thin silicon layers (200–300 nm) restrict both the mass block (critical for thermal noise suppression) and optical Q-factor. Enlarging the detection mass in such thin layers exacerbates in-plane height nonuniformity, severely limiting high-precision sensing. This study proposes a 500 nm thick silicon-based 2D slot-type PhC cavity design for advanced sensing applications, fabricated on a silicon-on-insulator (SOI) substrate with optimized air slot structures. Systematic parameter optimization via finite element simulations defines structural parameters for the 1550 nm band, followed by 6 × 6 × 6 combinatorial experiments on lattice constant, air hole radius, and line-defect waveguide width. Experimental results demonstrate a loaded Q-factor of 57,000 at 510 nm lattice constant, 175 nm air hole radius, and 883 nm line-defect waveguide width (measured sidewall angle: 88.4°). The thickened silicon layer delivers dual advantages: enhanced mass block for thermal noise reduction and high Q-factor for optomechanical coupling efficiency, alongside improved ridge waveguide compatibility. This work advances the practical development of CMOS-compatible micro-opto-electromechanical systems (MOEMS). Full article
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11 pages, 9716 KB  
Article
Scanning Micromirror Calibration Method Based on PSO-LSSVM Algorithm Prediction
by Yan Liu, Xiang Cheng, Tingting Zhang, Yu Xu, Weijia Cai and Fengtian Han
Micromachines 2024, 15(12), 1413; https://doi.org/10.3390/mi15121413 - 25 Nov 2024
Cited by 1 | Viewed by 3280
Abstract
Scanning micromirrors represent a crucial component in micro-opto-electro-mechanical systems (MOEMS), with a broad range of applications across diverse fields. However, in practical applications, several factors inherent to the fabrication process and the surrounding usage environment exert a considerable influence on the accuracy of [...] Read more.
Scanning micromirrors represent a crucial component in micro-opto-electro-mechanical systems (MOEMS), with a broad range of applications across diverse fields. However, in practical applications, several factors inherent to the fabrication process and the surrounding usage environment exert a considerable influence on the accuracy of measurements obtained with the micromirror. Therefore, it is essential to calibrate the scanning micromirror and its measurement system. This paper presents a novel scanning micromirror calibration method based on the prediction of a particle swarm optimization-least squares support vector machine (PSO-LSSVM). The objective is to establish a correspondence between the actual deflection angle of the micromirror and the output of the measurement system employing a regression algorithm, thereby enabling the prediction of the tilt angle of the micromirror. The decision factor (R2) for this model at the x-axis reaches a value of 0.9947. Full article
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24 pages, 6506 KB  
Review
Micro-Opto-Electro-Mechanical Systems for High-Precision Displacement Sensing: A Review
by Chenguang Xin, Yingkun Xu, Zhongyao Zhang and Mengwei Li
Micromachines 2024, 15(8), 1011; https://doi.org/10.3390/mi15081011 - 6 Aug 2024
Cited by 12 | Viewed by 4879
Abstract
High-precision displacement sensing has been widely used across both scientific research and industrial applications. The recent interests in developing micro-opto-electro-mechanical systems (MOEMS) have given rise to an excellent platform for miniaturized displacement sensors. Advancement in this field during past years is now yielding [...] Read more.
High-precision displacement sensing has been widely used across both scientific research and industrial applications. The recent interests in developing micro-opto-electro-mechanical systems (MOEMS) have given rise to an excellent platform for miniaturized displacement sensors. Advancement in this field during past years is now yielding integrated high-precision sensors which show great potential in applications ranging from photoacoustic spectroscopy to high-precision positioning and automation. In this review, we briefly summarize different techniques for high-precision displacement sensing based on MOEMS and discuss the challenges for future improvement. Full article
(This article belongs to the Special Issue Realizing Optical Control through Mechatronics Systems)
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18 pages, 1497 KB  
Review
A Review of the Characteristics of Light Pollution: Assessment Technique, Policy, and Legislation
by Ying Hao, Peiyao Wang, Zhongyao Zhang, Zhiming Xu and Dagong Jia
Energies 2024, 17(11), 2750; https://doi.org/10.3390/en17112750 - 4 Jun 2024
Cited by 13 | Viewed by 6715
Abstract
Light pollution from the use of artificial lighting poses significant impacts on human health, traffic safety, ecological environment, astronomy, and energy use. The advancement of characteristics of light pollution assessment technology has played a significant role in shaping prevention and control policies, thereby [...] Read more.
Light pollution from the use of artificial lighting poses significant impacts on human health, traffic safety, ecological environment, astronomy, and energy use. The advancement of characteristics of light pollution assessment technology has played a significant role in shaping prevention and control policies, thereby enabling measures, such as environmental standards and legislation and product procurement guidelines, but considerable variation in the definition, control strategies, and regulatory frameworks remains. Therefore, there is a need to review the characteristics of light pollution, including the assessment technique, policy, and legislation. Through the literature review, it can be found that technical standards are required to prevent light pollution. For example, light pollution is decreased by 6% in France through the legislation of artificial light. Key approaches are suggested to control global light pollution, including implementing ambient brightness zoning, regulating lighting product usage, and establishing dark sky reserves. Technology and policy should be integrated. The precise data coming from satellite imagery, drones, and balloons could provide guidance when making the policies. Full article
(This article belongs to the Topic Thermal Energy Transfer and Storage)
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21 pages, 21596 KB  
Article
The Design, Modeling and Experimental Investigation of a Micro-G Microoptoelectromechanical Accelerometer with an Optical Tunneling Measuring Transducer
by Evgenii Barbin, Tamara Nesterenko, Aleksej Koleda, Evgeniy Shesterikov, Ivan Kulinich, Andrey Kokolov and Anton Perin
Sensors 2024, 24(3), 765; https://doi.org/10.3390/s24030765 - 24 Jan 2024
Cited by 9 | Viewed by 2558
Abstract
This treatise studies a microoptoelectromechanical accelerometer (MOEMA) with an optical measuring transducer built according to the optical tunneling principle (evanescent coupling). The work discusses the design of the accelerometer’s microelectromechanical sensing element (MSE) and states the requirements for the design to achieve a [...] Read more.
This treatise studies a microoptoelectromechanical accelerometer (MOEMA) with an optical measuring transducer built according to the optical tunneling principle (evanescent coupling). The work discusses the design of the accelerometer’s microelectromechanical sensing element (MSE) and states the requirements for the design to achieve a sensitivity threshold of 1 µg m/s2 at a calculated eigenvalue of the MSE. The studies cover the selection of the dimensions, mass, eigenfrequency and corresponding stiffness of the spring suspension, gravity-induced cross-displacements. The authors propose and experimentally test an optical transducer positioning system represented by a capacitive actuator. This approach allows avoiding the restrictions in the fabrication of the transducer conditioned by the extremely high aspect ratio of deep silicon etching (more than 100). The designed MOEMA is tested on three manufactured prototypes. The experiments show that the sensitivity threshold of the accelerometers is 2 µg. For the dynamic range from minus 0.01 g to plus 0.01 g, the average nonlinearity of the accelerometers’ characteristics ranges from 0.7% to 1.62%. For the maximum dynamic range from minus 0.015 g to plus 0.05 g, the nonlinearity ranges from 2.34% to 2.9%, having the maximum deviation at the edges of the regions. The power gain of the three prototypes of accelerometers varies from 12.321 mW/g to 26.472 mW/g. The results provide broad prospects for the application of the proposed solutions in integrated inertial devices. Full article
(This article belongs to the Section Optical Sensors)
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17 pages, 7590 KB  
Article
An Investigation of Real-Time Active Noise Control for 10 kV Substation Noise Suppression
by Jinshan Yu, Zhongyuan Zheng, Yamin Li, Haohui Wang, Ying Hao, Xiaoxia Liang and Jianzheng Gao
Sustainability 2023, 15(18), 13430; https://doi.org/10.3390/su151813430 - 7 Sep 2023
Cited by 5 | Viewed by 3227
Abstract
Substation noise is a crucial factor that influences residents’ quality of life, especially in the densely residential areas. Despite small- and medium-sized transformer facilities having relatively low noise levels, due to their proximity to residential areas, they generate considerable annoyance, rendering them a [...] Read more.
Substation noise is a crucial factor that influences residents’ quality of life, especially in the densely residential areas. Despite small- and medium-sized transformer facilities having relatively low noise levels, due to their proximity to residential areas, they generate considerable annoyance, rendering them a focal point among environmental noise complaints. The predominant noise emitted by these facilities falls within the medium- and low-frequency spectrum range, and the conventional passive noise reduction techniques exhibit limited efficacy in attenuating such low-frequency noise. This study develops a real-time active noise control (ANC) system based on a digital signal processor, TMS320F28335, and various ANC methods, including Filtered-X Least Mean Squares (FxLMS), Normalized Filter-X Least Mean Squares (FxNLMS), and variable step-size FxLMS (VS-FxLMS), are evaluated for the low-frequency noise reduction. In addition, the substation noises at a residential community are measured, analyzed, and used as noise source together with a series of sinusoidal waves for evaluation of the ANC algorithms. Results show the ANC system are effective in attenuating most low-frequency noises (within 600 Hz) and the average noise reduction for the substation noises has achieved by more than 12 dB. Full article
(This article belongs to the Special Issue Application of Power System in Sustainable Energy Perspective)
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10 pages, 1016 KB  
Article
Photonic Crystals Fabricated by Two-Photon Polymerization with Mechanical Defects
by Victoria Paige Stinson, Nuren Shuchi, Dustin Louisos, Micheal McLamb, Glenn D. Boreman and Tino Hofmann
Optics 2023, 4(2), 300-309; https://doi.org/10.3390/opt4020021 - 4 Apr 2023
Cited by 6 | Viewed by 4024
Abstract
One-dimensional photonic crystals have been used in sensing applications for decades, due to their ability to induce highly reflective photonic bandgaps. In this study, one-dimensional photonic crystals with alternating low- and high-density layers were fabricated from a single photosensitive polymer (IP-Dip) by two-photon [...] Read more.
One-dimensional photonic crystals have been used in sensing applications for decades, due to their ability to induce highly reflective photonic bandgaps. In this study, one-dimensional photonic crystals with alternating low- and high-density layers were fabricated from a single photosensitive polymer (IP-Dip) by two-photon polymerization. The photonic crystals were modified to include a central defect layer with different elastic properties compared to the surrounding layers, for the first time. It was observed that the defect mode resonance can be controlled by compressive force. Very good agreement was found between the experimentally measured spectra and the model data. The mechanical properties of the flexure design used in the defect layer were calculated. The calculated spring constant is of similar magnitude to those reported for microsprings fabricated on this scale using two-photon polymerization. The results of this study demonstrate the successful control of a defect resonance in one-dimensional photonic crystals fabricated by two-photon polymerization by mechanical stimuli, for the first time. Such a structure could have applications in fields, such as micro-robotics, and in micro-opto–electro–mechanical systems (MOEMSs), where optical sensing of mechanical fluctuations is desired. Full article
(This article belongs to the Special Issue Opto-Thermo-Mechanical Interactions in Nano-Objects and Metasurfaces)
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22 pages, 12055 KB  
Article
An Optical Measuring Transducer for a Micro-Opto-Electro-Mechanical Micro-g Accelerometer Based on the Optical Tunneling Effect
by Evgenii Barbin, Tamara Nesterenko, Aleksei Koleda, Evgeniy Shesterikov, Ivan Kulinich and Andrey Kokolov
Micromachines 2023, 14(4), 802; https://doi.org/10.3390/mi14040802 - 31 Mar 2023
Cited by 5 | Viewed by 2462
Abstract
Micro-opto-electro-mechanical (MOEM) accelerometers that can measure small accelerations are attracting growing attention thanks to their considerable advantages—such as high sensitivity and immunity to electromagnetic noise—over their rivals. In this treatise, we analyze 12 schemes of MOEM-accelerometers, which include a spring mass and a [...] Read more.
Micro-opto-electro-mechanical (MOEM) accelerometers that can measure small accelerations are attracting growing attention thanks to their considerable advantages—such as high sensitivity and immunity to electromagnetic noise—over their rivals. In this treatise, we analyze 12 schemes of MOEM-accelerometers, which include a spring mass and a tunneling-effect-based optical sensing system containing an optical directional coupler consisting of a fixed and a movable waveguide separated by an air gap. The movable waveguide can perform linear and angular movement. In addition, the waveguides can lie in single or different planes. Under acceleration, the schemes feature the following changes to the optical system: gap, coupling length, overlapping area between the movable and fixed waveguides. The schemes with altering coupling lengths feature the lowest sensitivity, yet possess a virtually unlimited dynamic range, which makes them comparable to capacitive transducers. The sensitivity of the scheme depends on the coupling length and amounts to 11.25 × 103 m−1 for a coupling length of 44 μm and 30 × 103 m−1 for a coupling length of 15 μm. The schemes with changing overlapping areas possess moderate sensitivity (1.25 × 106 m−1). The highest sensitivity (above 6.25 × 106 m−1) belongs to the schemes with an altering gap between the waveguides. Full article
(This article belongs to the Special Issue Optical MEMS, Volume III)
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13 pages, 5166 KB  
Article
Sensitivity Improvement of an Optical Fiber Sensor Based on Surface Plasmon Resonance with Pure Higher-Order Modes
by Chuanhao Yang, Bing Yan, Qi Wang, Jing Zhao, Hongxia Zhang, Hui Yu, Haojun Fan and Dagong Jia
Appl. Sci. 2023, 13(6), 4020; https://doi.org/10.3390/app13064020 - 22 Mar 2023
Cited by 11 | Viewed by 3294
Abstract
In this paper, we propose an approach to improve the sensitivity of an optical fiber surface plasmon resonance (SPR) sensor with a pure higher-order mode excited by a designed mode selective coupler (MSC). We calculate the proportion of the power of the higher-order [...] Read more.
In this paper, we propose an approach to improve the sensitivity of an optical fiber surface plasmon resonance (SPR) sensor with a pure higher-order mode excited by a designed mode selective coupler (MSC). We calculate the proportion of the power of the higher-order mode in the cladding. Compared to the LP01 mode, the power proportion of the LP11 mode (LP21 mode) in the cladding theoretically improves by 100% (150%). To generate a relatively pure LP11 mode or LP21 mode, a mode selective coupler (MSC, 430–580 nm) is designed. The coupling efficiency of the LP01LP11 mode coupler is over 80%, and that of the LP01LP21 mode coupler is over 50%. The simulation results show that the sensitivity of the LP11  mode and the LP21 mode increases by approximately 330% and 360%, respectively, using the intensity modulation (n = 1.33–1.38, 430–580 nm); the resolution of the refractive indices of our sensor, using the LP11 mode (LP21 mode), is 2.6×104 RIU (2.4×104 RIU). The higher sensitivity and resolution of our presented fiber SPR sensor containing a visible MSC make it a promising candidate for the measurement of refractive indices. Full article
(This article belongs to the Topic Machine Learning and Biomedical Sensors)
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15 pages, 17854 KB  
Article
Design and Development of a MOEMS Accelerometer Using SOI Technology
by José Mireles, Ángel Sauceda, Abimael Jiménez, Manuel Ramos and Rafael Gonzalez-Landaeta
Micromachines 2023, 14(1), 231; https://doi.org/10.3390/mi14010231 - 16 Jan 2023
Cited by 12 | Viewed by 5607
Abstract
The micro-electromechanical system (MEMS) sensors are suitable devices for vibrational analysis in complex systems. The Fabry–Pérot interferometer (FPI) is used due to its high sensitivity and immunity to electromagnetic interference (EMI). Here, we present the design, fabrication, and characterization of a silicon-on-insulator (SOI) [...] Read more.
The micro-electromechanical system (MEMS) sensors are suitable devices for vibrational analysis in complex systems. The Fabry–Pérot interferometer (FPI) is used due to its high sensitivity and immunity to electromagnetic interference (EMI). Here, we present the design, fabrication, and characterization of a silicon-on-insulator (SOI) MEMS device, which is embedded in a metallic package and connected to an optical fiber. This integrated micro-opto-electro-mechanical system (MOEMS) sensor contains a mass structure and handle layers coupled with four designed springs built on the device layer. An optical reading system using an FPI is used for displacement interrogation with a demodulation technique implemented in LabVIEW®. The results indicate that our designed MOEMS sensor exhibits a main resonant frequency of 1274 Hz with damping ratio of 0.0173 under running conditions up to 7 g, in agreement with the analytical model. Our experimental findings show that our designed and fabricated MOEMS sensor has the potential for engineering application to monitor vibrations under high-electromagnetic environmental conditions. Full article
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13 pages, 2047 KB  
Article
Design and Simulation Study of an Optical Mode-Localized MEMS Accelerometer
by Yu Feng, Wuhao Yang and Xudong Zou
Micromachines 2023, 14(1), 39; https://doi.org/10.3390/mi14010039 - 23 Dec 2022
Cited by 3 | Viewed by 3125
Abstract
In this paper, we demonstrate a novel photonic integrated accelerometer based on the optical mode localization sensing mechanism, which is designed on an SOI wafer with a device layer thickness of 220 nm. High sensitivity and large measurement range can be achieved by [...] Read more.
In this paper, we demonstrate a novel photonic integrated accelerometer based on the optical mode localization sensing mechanism, which is designed on an SOI wafer with a device layer thickness of 220 nm. High sensitivity and large measurement range can be achieved by integrating coupled ring resonators with a suspended directional coupler on a proof mass. With the help of FEA simulation and numerical analysis, the proposed optical mode-localized sensor presents a sensitivity of 10/g (modal power ratio/acceleration) and an inertial displacement of from −8 to 10 microns corresponding to a range from −23.5 to 29.4 g. The free spectral range is 4.05 nm around 1.55 microns. The acceleration resolution limited by thermomechanical noise is 4.874 μg. The comprehensive performance of this design is competitive with existing MEMS mode localized accelerometers. It demonstrates the potential of the optical mode-localized inertial sensors as candidates for state-of-the-art sensors in the future. Full article
(This article belongs to the Special Issue MEMS Accelerometers: Design, Applications and Characterization)
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12 pages, 3433 KB  
Article
Prefab Hollow Glass Microsphere-Based Immunosensor with Liquid Crystal Sensitization for Acute Myocardial Infarction Biomarker Detection
by Panpan Niu, Junfeng Jiang, Kun Liu, Shuang Wang, Tianhua Xu, Ziyihui Wang, Tong Wang, Xuezhi Zhang, Zhenyang Ding, Yize Liu and Tiegen Liu
Biosensors 2022, 12(7), 439; https://doi.org/10.3390/bios12070439 - 22 Jun 2022
Cited by 5 | Viewed by 3178
Abstract
Quantitative detection of cardiac troponin biomarkers in blood is an important method for clinical diagnosis of acute myocardial infarction (AMI). In this work, a whispering gallery mode (WGM) microcavity immunosensor based on a prefab hollow glass microsphere (HGMS) with liquid crystal (LC) sensitization [...] Read more.
Quantitative detection of cardiac troponin biomarkers in blood is an important method for clinical diagnosis of acute myocardial infarction (AMI). In this work, a whispering gallery mode (WGM) microcavity immunosensor based on a prefab hollow glass microsphere (HGMS) with liquid crystal (LC) sensitization was proposed and experimentally demonstrated for label-free cardiac troponin I-C (cTnI-C) complex detection. The proposed fiber-optic immunosensor has a simple structure; the tiny modified HGMS serves as the key sensing element and the microsample reservoir simultaneously. A sensitive LC layer with cTnI-C recognition ability was deposited on the inner wall of the HGMS microcavity. The arrangement of LC molecules is affected by the cTnI-C antigen—antibody binding in the HGMS, and the small change of the surface refractive index caused by the binding can be amplified owing to the birefringence property of LC. Using the annular waveguide of the HGMS, the WGMs were easily excited by the coupling scanning laser with a microfiber, and an all-fiber cTnI-C immunosensor can be achieved by measuring the resonant wavelength shift of the WGM spectrum. Moreover, the dynamic processes of the cTnI-C antigen—antibody binding and unbinding was revealed by monitoring the wavelength shift continuously. The proposed immunosensor with a spherical microcavity can be a cost-effective tool for AMI diagnosis. Full article
(This article belongs to the Special Issue Electrochemistry and Spectroscopy-Based Biosensors)
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53 pages, 4210 KB  
Review
Miniaturized NIR Spectroscopy in Food Analysis and Quality Control: Promises, Challenges, and Perspectives
by Krzysztof B. Beć, Justyna Grabska and Christian W. Huck
Foods 2022, 11(10), 1465; https://doi.org/10.3390/foods11101465 - 18 May 2022
Cited by 224 | Viewed by 23478
Abstract
The ongoing miniaturization of spectrometers creates a perfect synergy with the common advantages of near-infrared (NIR) spectroscopy, which together provide particularly significant benefits in the field of food analysis. The combination of portability and direct onsite application with high throughput and a noninvasive [...] Read more.
The ongoing miniaturization of spectrometers creates a perfect synergy with the common advantages of near-infrared (NIR) spectroscopy, which together provide particularly significant benefits in the field of food analysis. The combination of portability and direct onsite application with high throughput and a noninvasive way of analysis is a decisive advantage in the food industry, which features a diverse production and supply chain. A miniaturized NIR analytical framework is readily applicable to combat various food safety risks, where compromised quality may result from an accidental or intentional (i.e., food fraud) origin. In this review, the characteristics of miniaturized NIR sensors are discussed in comparison to benchtop laboratory spectrometers regarding their performance, applicability, and optimization of methodology. Miniaturized NIR spectrometers remarkably increase the flexibility of analysis; however, various factors affect the performance of these devices in different analytical scenarios. Currently, it is a focused research direction to perform systematic evaluation studies of the accuracy and reliability of various miniaturized spectrometers that are based on different technologies; e.g., Fourier transform (FT)-NIR, micro-optoelectro-mechanical system (MOEMS)-based Hadamard mask, or linear variable filter (LVF) coupled with an array detector, among others. Progressing technology has been accompanied by innovative data-analysis methods integrated into the package of a micro-NIR analytical framework to improve its accuracy, reliability, and applicability. Advanced calibration methods (e.g., artificial neural networks (ANN) and nonlinear regression) directly improve the performance of miniaturized instruments in challenging analyses, and balance the accuracy of these instruments toward laboratory spectrometers. The quantum-mechanical simulation of NIR spectra reveals the wavenumber regions where the best-correlated spectral information resides and unveils the interactions of the target analyte with the surrounding matrix, ultimately enhancing the information gathered from the NIR spectra. A data-fusion framework offers a combination of spectral information from sensors that operate in different wavelength regions and enables parallelization of spectral pretreatments. This set of methods enables the intelligent design of future NIR analyses using miniaturized instruments, which is critically important for samples with a complex matrix typical of food raw material and shelf products. Full article
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