Search Results (56)

This review article provides an introductory overview of organic bioelectronics, focusing on the creation of electrical devices that use specialized carbon-based semiconducting materials to interact successfully with biological processes. These organic materials demonstrate flexibility, biocompatibility, and the capacity to carry both electrical and ionic impulses, making them an ideal choice for connecting human tissue with electronic technology. The review study examines diverse materials, such as the conductive polymers Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) and Polyaniline (PANI), along with critical devices like organic electrochemical transistors (OECTs), which are exceptionally efficient for sensitive biosensing applications. Significant applications include implanted neural interfaces for the brain and nerves, wearable health monitoring, tissue engineering scaffolds that facilitate tissue repair, and sophisticated drug delivery systems. The review acknowledges current challenges, including long-term stability and safety, while envisioning a future where these technologies revolutionize healthcare, human–machine interaction, and environmental monitoring via continuous multidisciplinary innovation. Full article

The growing burden of degenerative, cardiovascular, neurodegenerative, and cancerous diseases necessitates innovative approaches to improve our pathophysiological understanding and ability to modulate biological processes. Organic bioelectronics has emerged as a powerful tool in this pursuit, offering a unique ability to interact with biology due to the mixed ionic–electronic conduction and tissue-mimetic mechanical properties of conducting polymers (CPs). These materials enable seamless integration with biological systems across different levels of complexity, from monolayers to complex 3D models, microfluidic chips, and even clinical applications. CPs can be processed into diverse formats, including thin films, hydrogels, 3D scaffolds, and electrospun fibers, allowing the fabrication of advanced bioelectronic devices such as multi-electrode arrays, transistors (EGOFETs, OECTs), ion pumps, and photoactuators. This review examines the integration of CP-based bioelectronics in vivo and in in vitro microphysiological systems, focusing on their ability to monitor key biological events, including electrical activity, metabolic changes, and biomarker concentrations, as well as their potential for electrical, mechanical, and chemical stimulation. We highlight the versatility and biocompatibility of CPs and their role in advancing personalized medicine and regenerative therapies and discuss future directions for organic bioelectronics to bridge the gap between biological systems and electronic technologies. Full article

Gel electrolyte-gated organic electrochemical transistors (OECTs) are promising bioelectronic devices known for their high transconductance, low operating voltage, and integration with biological systems. Despite extensive research on the performance of OECTs, a precise model defining the dependence of OECT performance on gel electrolytes is still lacking. In this work, we refine the device model to comprehensively account for the electrical double layer (EDL)’s capacitance of the gel electrolyte. Both experimental data and theoretical calculations indicate that the maximum transconductance of the OECT is contingent upon ion concentration, drain voltage, and scan rate, highlighting a strong correlation between the transconductance and the hydrogel electrolyte. Overall, this model serves as a theoretical tool for improving the performance of OECTs, enabling the further development of bioelectronic devices. Full article

Flexible sensors are revolutionizing wearable and implantable devices, with conductive hydrogels emerging as key materials due to their biomimetic structure, biocompatibility, tunable transparency, and stimuli-responsive electrical properties. However, their fragility and limited durability pose significant challenges for broader applications. Drawing inspiration from the self-healing capabilities of natural organisms like mussels, researchers are embedding self-repair mechanisms into hydrogels to improve their reliability and lifespan. This review highlights recent advances in self-healing (SH) conductive hydrogels, focusing on synthesis methods, healing mechanisms, and strategies to enhance multifunctionality. It also explores their wide-ranging applications, including in vivo signal monitoring, wearable biochemical sensors, supercapacitors, flexible displays, triboelectric nanogenerators, and implantable bioelectronics. While progress has been made, challenges remain in balancing self-healing efficiency, mechanical strength, and sensing performance. This review offers insights into overcoming these obstacles and discusses future research directions for advancing SH hydrogel-based bioelectronics, aiming to pave the way for durable, high-performance devices in next-generation wearable and implantable technologies. Full article

Interfaces between implantable bioelectrodes and tissues provide critical insights into the biological and pathological conditions of targeted organs, aiding diagnosis and treatment. While conventional bioelectronics, made from rigid materials like metals and silicon, have been essential for recording signals and delivering electric stimulation, they face limitations due to the mechanical mismatch between rigid devices and soft tissues. Recently, focus has shifted toward soft conductive materials, such as conductive hydrogels and hydrogel nanocomposites, known for their tissue-like softness, biocompatibility, and potential for functionalization. This review introduces these materials and provides an overview of recent advances in soft hydrogel nanocomposites for implantable electronics. It covers material strategies for conductive hydrogels, including both intrinsically conductive hydrogels and hydrogel nanocomposites, and explores key functionalization techniques like biodegradation, bioadhesiveness, injectability, and self-healing. Practical applications of these materials in implantable electronics are also highlighted, showcasing their effectiveness in real-world scenarios. Finally, we discuss emerging technologies and future needs for chronically implantable bioelectronics, offering insights into the evolving landscape of this field. Full article

Advancements in electronic device technology have led to an exponential growth in demand for more efficient and versatile transistors. In this context, organic field-effect transistors (OFETs) have emerged as a promising alternative due to their unique properties and potential for flexible and low-cost applications. However, to overcome some of the inherent limitations of OFETs, the integration of organic materials with other materials and technologies has been proposed, giving rise to a new generation of hybrid devices. In this article, we explore the development and advances of organic field-effect transistors and highlight the growing importance of hybrid devices in this area. In particular, we focus on three types of emerging hybrid devices: organic electrochemical transistors (OECTs), organic light-emitting field-effect transistors (OLEFETs) and organic field-effect waveguides (OFEWs). These devices combine the advantages of organic materials with the unique capabilities of other technologies, opening up new possibilities in fields such as flexible electronics, bioelectronics, or optoelectronics. This article provides an overview of recent advances in the development and applications of hybrid transistors, highlighting their crucial role in the next generation of electronic devices. Full article

Organic electrochemical transistors (OECTs) have attracted considerable interest in the context of wearable and implantable biosensors due to their remarkable signal amplification combined with seamless integration into biological systems. These properties underlie OECTs’ potential utility across a range of bioelectronic applications. One of the main challenges to their practical applications is the mechanical limitation of PEDOT:PSS, the most typical conductive polymer used as a channel layer, when the OECTs are applied to implantable and stretchable bioelectronics. In this work, we address this critical issue by employing natural rubber latex (NRL) as an additive in PEDOT:PSS to improve flexibility and stretchability of the OECT channels. Although the inclusion of NRL leads to a decrease in transconductance, mainly due to a reduced carrier mobility from 0.3 to 0.1 cm²/V·s, the OECTs maintain satisfactory transconductance, exceeding 5 mS. Furthermore, it is demonstrated that the OECTs exhibit excellent mechanical stability while maintaining their performance even after 100 repetitive bending cycles. This work, therefore, suggests that the NRL/PEDOT:PSS composite film can be deployed for wearable/implantable applications, where high mechanical stability is needed. This finding opens up new avenues for practical use of OECTs in more robust and versatile wearable and implantable biosensors. Full article

We present the construction of an organic electrochemical transistor (OECT) based on poly(3,4-ethylendioxythiophene, PEDOT) and polyallylamine (PAH) and its evaluation as a bioelectronic platform for urease integration and urea sensing. The OECT channel was fabricated in a one-step procedure using chemical polymerization. Then, urease was immobilized on the surface by electrostatic interaction of the negatively charged enzyme at neutral pH with the positively charged surface of PEDOH-PAH channels. The real-time monitoring of the urease adsorption process was achieved by registering the changes on the drain–source current of the OECT upon continuous scan of the gate potential during enzyme deposition with high sensitivity. On the other hand, integrating urease enabled urea sensing through the transistor response changes resulting from local pH variation as a consequence of enzymatic catalysis. The response of direct enzyme adsorption is compared with layer-by-layer integration using polyethylenimine. Integrating a polyelectrolyte over the adsorbed enzyme resulted in a more stable response, allowing for the sensing of urine even from diluted urine samples. These results demonstrate the potential of integrating enzymes into the active channels of OECTs for the development of biosensors based on local pH changes. Full article

The global challenges posed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have underscored the critical importance of innovative and efficient control systems for addressing future pandemics. The most effective way to control the pandemic is to rapidly suppress the spread of the virus through early detection using a rapid, accurate, and easy-to-use diagnostic platform. In biosensors that use bioprobes, the binding affinity of molecular recognition elements (MREs) is the primary factor determining the dynamic range of the sensing platform. Furthermore, the sensitivity relies mainly on bioprobe quality with sufficient functionality. This comprehensive review investigates aptamers and nanobodies recently developed as advanced MREs for SARS-CoV-2 diagnostic and therapeutic applications. These bioprobes might be integrated into organic bioelectronic materials and devices, with promising enhanced sensitivity and specificity. This review offers valuable insights into advancing biosensing technologies for infectious disease diagnosis and treatment using aptamers and nanobodies as new bioprobes. Full article

In recent decades, considerable attention has been focused on the design and development of surfaces with defined or tunable properties for a wide range of applications and fields. To this end, self-assembled monolayers (SAMs) of organic compounds offer a unique and straightforward route of modifying and engineering the surface properties of any substrate. Thus, alkane-based self-assembled monolayers constitute one of the most extensively studied organic thin-film nanomaterials, which have found wide applications in antifouling surfaces, the control of wettability or cell adhesion, sensors, optical devices, corrosion protection, and organic electronics, among many other applications, some of which have led to their technological transfer to industry. Nevertheless, recently, aromatic-based SAMs have gained importance as functional components, particularly in molecular electronics, bioelectronics, sensors, etc., due to their intrinsic electrical conductivity and optical properties, opening up new perspectives in these fields. However, some key issues affecting device performance still need to be resolved to ensure their full use and access to novel functionalities such as memory, sensors, or active layers in optoelectronic devices. In this context, we will present herein recent advances in π-conjugated systems-based self-assembled monolayers (e.g., push–pull chromophores) as active layers and their applications. Full article

Piezoelectric polymers are a class of material that belong to carbon–hydrogen-based organic materials with a long polymer chain. They fill the void where single crystals and ceramics fail to perform. This characteristic of piezoelectric polymers made them unique. Their piezoelectric stress constant is higher than ceramics and the piezoelectric strain is lower compared to ceramics. This study’s goal is to present the most recent information on poly(vinylidene fluoride) with trifluoroethylene P(VDF-TrFE), a major copolymer of poly(vinylidene fluoride) PVDF with piezoelectric, pyroelectric, and ferroelectric characteristics. The fabrication of P(VDF-TrFE) composites and their usage in a variety of applications, including in actuators, transducers, generators, and energy harvesting, are the primary topics of this work. The report provides an analysis of how the addition of fillers improves some of the features of P(VDF-TrFE). Commonly utilized polymer composite preparation techniques, including spinning, Langmuir–Blodgett (LB), solution casting, melt extrusion, and electrospinning are described, along with their effects on the pertinent characteristics of the polymer composite. A brief discussion on the literature related to different applications (such as bio-electronic devices, sensors and high energy-density piezoelectric generators, low mechanical damping, and easy voltage rectifiers of the polymer composite is also presented. Full article

In recent decades, the rapid development of the global economy has led to a substantial increase in energy consumption, subsequently resulting in the emission of a significant quantity of toxic gases into the environment. So far, gas sensors based on polymer field-effect transistors (PFETs), a highly practical and cost-efficient strategy, have garnered considerable attention, primarily attributed to their inherent advantages of offering a plethora of material choices, robust flexibility, and cost-effectiveness. Notably, the development of functional organic semiconductors (OSCs), such as poly(3-hexylthiophene-2,5-diyl) (P3HT), has been the subject of extensive scholarly investigation in recent years due to its widespread availability and remarkable sensing characteristics. This paper provides an exhaustive overview encompassing the production, functionalization strategies, and practical applications of gas sensors incorporating P3HT as the OSC layer. The exceptional sensing attributes and wide-ranging utility of P3HT position it as a promising candidate for improving PFET-based gas sensors. Full article

Skin has a dynamic surface and offers essential information through biological signals originating from internal organs, blood vessels, and muscles. Soft and stretchable bioelectronics can be used in wearable machines for long-term stability and to continuously obtain distinct bio-signals in conjunction with repeated expansion and contraction with physical activities. While monitoring bio-signals, the electrode and skin must be firmly attached for high signal quality. Furthermore, the signal-to-noise ratio (SNR) should be high enough, and accordingly, the ionic conductivity of an adhesive hydrogel needs to be improved. Here, we used a chitosan-alginate-chitosan (CAC) triple hydrogel layer as an interface between the electrodes and the skin to enhance ionic conductivity and skin adhesiveness and to minimize the mechanical mismatch. For development, thermoplastic elastomer Styrene-Ethylene-Butylene-Styrene (SEBS) dissolved in toluene was used as a substrate, and gold nanomembranes were thermally evaporated on SEBS. Subsequently, CAC triple layers were drop-casted onto the gold surface one by one and dried successively. Lastly, to demonstrate the performance of our electrodes, a human electrocardiogram signal was monitored. The electrodes coupled with our CAC triple hydrogel layer showed high SNR with clear PQRST peaks. Full article

Elaboration of biosensors on the base of organic transistors with embedded biomolecules which can operate in an aqueous environment is of paramount importance. Electrolyte-gated organic field-effect transistors demonstrate high sensitivity in detection of various analytes. In this paper, we demonstrated the possibility of quantitative fast specific determination of virus particles by an aptasensor based on EGOFET. The sensitivity and selectivity of the devices were examined with the influenza A virus as well as with control bioliquids like influenza B, Newcastle disease viruses or allantoic fluid with different dilutions. The influence of the semiconducting layer thickness on EGOFETs sensory properties is discussed. The fabrication of a multi-flow cell that simultaneously registers the responses from several devices on the same substrate and the creation of a multi-sensor flow device are reported. The responses of the elaborated bioelectronic platform to the influenza A virus obtained with application of the portable multi-flow mode are well correlated with the responses obtained in the laboratory stationary mode. Full article

Dynamic glucose monitoring is important to reduce the risk of metabolic diseases such as diabetes. Wearable biosensors based on organic electrochemical transistors (OECTs) have been developed due to their excellent signal amplification capabilities and biocompatibility. However, traditional wearable biosensors are fabricated on flat substrates with limited gas permeability, resulting in the inefficient evaporation of sweat, reduced wear comfort, and increased risk of inflammation. Here, we proposed breathable OECT-based glucose sensors by designing a porous structure to realize optimal breathable and stretchable properties. The gas permeability of the device and the relationship between electrical properties under different tensile strains were carefully investigated. The OECTs exhibit exceptional electrical properties (g_m ~1.51 mS and I_on ~0.37 mA) and can retain up to about 44% of their initial performance even at 30% stretching. Furthermore, obvious responses to glucose have been demonstrated in a wide range of concentrations (10⁻⁷–10⁻⁴ M) even under 30% strain, where the normalized response to 10⁻⁴ M is 26% and 21% for the pristine sensor and under 30% strain, respectively. This work offers a new strategy for developing advanced breathable and wearable bioelectronics. Full article