Search Results (251)

Background/Objectives: Radiodermitis is an inflammatory or dystrophic skin process caused by the direct action of ionizing radiation. The primary objective was to study two clinical cases. The secondary objective was to propose the foundations of an intelligent system for decision support in complex cases of radiodermitis diagnosis that can operate even in the case of a low amount of available clinical data that can be used for training. Methods: The first case is a female patient, aged 74 years, with squamous cell carcinoma on a chronic radiodermitis site, which appeared after 20 years of local radiotherapy treatment for mammary adenocarcinoma. Dermatologic examination revealed five round-oval nodules between 2 and 8 cm in diameter. They were pink colored with lilac edges, hard and infiltrated on palpation, adherent to the subcutaneous tissue, painless, and located above and lateral on the right chest and the upper region of the right hypochondrium. The second case concerns a 60-year-old patient with verrucous squamous cell carcinoma appearing on a chronic radiodermatitis 40 years after local radio-therapeutic treatment with Chaoul rays for a deep right temporal region mycosis. There are presented artificial intelligence (AI) challenges regarding the application of advanced hybrid models in decision support for diagnosis of difficult radiodermitis cases, in that intelligent computing must be made in the context of very little available data, and collaboration between physicians is necessary. Results: Both cases were confirmed by histology as squamos cell carcinomas. In the AI research, the adaptation of the IntMediSys intelligent system was proposed for solving complex cases of radiodermitis. The proposal integrates different AI technologies, which include agents, intelligent computing, and blackboard systems. Conclusions: The presented first cases confirm the presence of a squamous cell carcinoma that appeared on chronic radiodermitis after a long latency. The foundations of a highly complex collaboration and decision support system that can assist physicians in the radiodermitis diagnostics establishment that opens the path for further development are presented. Full article

Pulse wave velocity (PWV) has been recognised as the gold standard for assessing arterial stiffness and a relevant indicator in diagnosing cardiovascular disease. Conventional approaches can be affected by factors such as the size of the probe, its positioning on the skin with the appropriate angle and magnitude of the incident force, or influenced by optical properties. Aiming at improving the assessment of PWV parameter, an important cardiovascular risk marker, the present study introduces a new arterial pulse wave measurement technique based on measurements of the impedance phase characteristics of giant magneto-impedance (GMI) sensors submitted to slight magnetic field variations caused by the displacement of a small magnetic marker placed on the patient’s skin, whose movement is coordinated by the local pressure wave. The proposed method eliminates the necessity of using probes with mechanical amplification, enhancing spatial resolution and usability in hard-to-reach anatomical regions through a contactless device unaffected by optical parameters. The obtained experimental results indicate the potential of the developed measurement system in measuring arterial pulse waveform and PWV. Full article

Scarring is a prevalent and often undesirable outcome of the wound healing process, impacting millions worldwide. The complex and dynamic nature of wound healing, including hemostasis, inflammation, proliferation, and remodeling, necessitates precise, making it hard for stage-specific interventions to prevent pathological scarring. This study introduces a double-layer hydrogel system designed for sequential drug release, aligning with the stage-specific need for wound healing. The lower layer, containing curcumin-loaded chitosan nanoparticles, shows early anti-inflammatory and antioxidant effects, while the upper layer, with pirfenidone-encapsulated gelatin microspheres, presents late-stage anti-fibrotic activity. The hydrogel’s unique design, with varying degradation rates and mechanical properties in each layer, facilitates cascade drug release in synchrony with wound healing stages. Rapid release of curcumin from the lower layer promotes proliferation by mitigating inflammation and oxidative stress, while the sustained release of pirfenidone from the upper layer inhibits excessive fibrillation during late proliferation and remodeling. In a rat model of full-thickness skin defect, treatment with a double-layer hydrogel drug delivery system accelerated the wound closure, improved scar quality, and promoted the formation of hair follicles. Therefore, this innovative approach lays a promising foundation for future clinical applications in anti-scar therapies, offering a significant advancement in wound care and regenerative medicine. Full article

In recent years, robotics has made notable progress, becoming an essential component of daily life by facilitating complex tasks and enhancing human experiences. While most robots have traditionally featured hard surfaces, the growing demand for more comfortable and safer human–robot interactions has driven the development of soft robots. One type of soft robot, which incorporates innovative skin materials, transforms rigid structures into more pliable and adaptive forms, making them better suited for interacting with humans. Especially in healthcare and rehabilitation, robotic skin technology has gained substantial attention, offering transformative solutions for improving the functionality of prosthetics, exoskeletons, and companion robots. Although replicating the complex sensory functions of human skin remains a challenge, ongoing research in soft robotics focuses on developing sensors that mimic the softness and tactile sensitivity necessary for effective interaction. This review provides a narrative analysis of current trends in robotic skin development, specifically tailored for healthcare and rehabilitation applications, including skin types of sensor technologies, materials, challenges, and future research directions in this rapidly developing field. Full article

In this paper, edible composite coatings, which used chitosan (CTS) as the matrix material, glycerol as the plasticizer, and natamycin as the antibacterial material, were prepared and composite films were prepared by a casting method. Taking cherry tomatoes as the research models, the optimal preservation effect of the composite coating was achieved using 10 g/L CTS, 2.5 g/L glycerol, and 125 mg/L natamycin under conditions of 25 °C and 50% RH. The thickness, transparency, water vapor transmittance (WVT), tensile strength (TS), and elongation at break (EB) of composite film were measured and the results showed the film prepared using 10 g/L CTS, 2.5 g/L glycerol and 125 mg/L natamycin was the best. The direct application of the optimal coating to cherry tomatoes kept the cherry tomatoes valuable for 20 days. The weight loss rate and hardness loss rate were reduced by 22.13% and 12.55%, respectively. The total soluble solid (TSS) content and vitamin c (Vc) content were increased by 2.54% and 20.35%, respectively. The malondialdehyde (MDA) content and peroxidase (POD) activity were decreased by 19.38% and 28.03%, respectively. Based on the significant preservation effect of the composite coating, it is expected to be widely used in the preservation of fruits and vegetables with skin morphologies similar to cherry tomatoes. Full article

Background: The reconstruction of extensive full-thickness lower eyelid defects constitutes a challenge for plastic surgeons. Various techniques have been described to cater to patients’ specific defect needs, with the aim of achieving the best results. Materials and Methods: We performed a retrospective observational study assessing our experience with a combination of a single-stage procedure consisting of a hard palate graft and a Fricke flap for patients with complex lower lid resections undergoing immediate total reconstruction at our institution. Clinical data, histological type and results, size of tumor, recurrences, and post-operative complications were collected to evaluate outcomes. A Visual Analogue 10-point scale was administered to all patients to assess esthetic and functional outcomes. Results: Seven lower lid reconstructions were performed, with all patients receiving immediate reconstruction. The age of the patients ranged from 55 to 82. Five skin cancers were located on the right side and three on the left side. In all cases, histological diagnosis was non-melanoma skin cancers. The mean size of the tumor was 1.7 × 1.7. In all patients, negative surgical margins were obtained. All patients underwent 24-month follow up. No immediate complication from surgery was recorded within the first 30 days. During follow-up, lower lid ectropion was observed in one patient due to the development of a retracting scar. No local cancer recurrence or nodal metastasis were detected until 2 years follow-up. In only one case, adjuvant therapy was required. The aesthetic results were deemed satisfactory by all patients. Conclusions: According to our experience, the combination of a Fricke flap and hard palate graft is an excellent option for total lower eyelid reconstruction, with low morbidity and favorable outcomes, even in elderly and frail patients where satisfactory results were achieved in a single-stage procedure and short operative times. Full article

Background: Facial aging involves soft and hard tissues with changes that can affect an individual’s self-esteem and aesthetic appearance. Techniques used to counteract these changes include the use of solutions to be injected into the dermis, such as dermal matrix, vitamins, and antioxidants. B vitamins and choline are vital nutrition for humans and many other animals (vitamin B4), required to produce acetylcholine (ACh). It is considered a neurotransmitter universal methyl donator and of the major membrane constituent phosphatidylcholine (PC) and is crucial for the functioning of cell membranes, including those in skeletal muscle cells. The aim of this study is to evaluate the efficacy and safety of a fragment of HA amino acid and choline in a solution of phosphate buffer system used via mesotherapy. Specifically, state that the primary endpoint was the efficacy assessment using the Scientific Assessment Scale of Skin Quality (SASSQ), while secondary endpoints included safety assessments and patient-reported outcomes. Methods: Forty (40) subjects completed the study. In total, 40 subjects were screened and included in the study. The total duration of the study was 14 months. The first subject was included on 12 January 2019, and the last subject’s last visit was on 14 March 2020. All patients received the SKIN Colin^® products by mesotherapy technique for 8 weeks, providing the treatment with the use of 0.5 cc syringes and 13 mm long, 30 G diameter needles. The solution was inoculated into the deep layer of the dermis of the face with a suitable amount of at least 0.2/0.3 mL in the cutaneous points four times every 15 days. Each subject had to be followed for 168 days after the last mesotherapy session. Only enrolled subjects received the HA and choline via mesotherapy. The primary efficacy endpoint was the absolute change in the Scientific Assessment Scale of Skin Quality from Baseline (Day 0) to Day 168. A reduction of at least one point in the SASSQ was considered to reach the endpoint goal. Results: The results of the present investigation show Scientific Assessment Scale of Skin Quality (SASSQ) mean at baseline was 2463 with a standard deviation of 0.36, while at day 168, the mean was 1303 with a standard deviation of 0.36. The difference was statistically significant (p < 0.0001). Also, the GAIS was improved after treatment with Skin Colin^®. The assessment of “satisfaction with treatment” was very high by the majority of subjects. Conclusions: In conclusion, our results suggest that a course of treatment with choline via mesotherapy results in an improvement of the Scientific Assessment Scale of Skin Quality. This data is very important for possible fields of application in the treatment of skin and muscle aging. However, the present study has limitations due to the small sample size and the lack of a control group. Full article

Alkyd resins are still one of the most important classes of binders for paint systems. They are outstanding in terms of their versatility of formulations and applications, cost-effectiveness, and durability. Traditionally, they are synthesized using phthalic anhydride, polyalcohols with three or four functional groups (pentaerythritol, glycerol, and trimethylolpropane), and fatty acids or oils. In this study, new bio-alkyd resins were synthesized with the objective of increasing the bio-based content by substituting phthalic anhydride, thereby also enhancing the biodegradability of coatings. The newly synthesized alkyd resins, formulated with azelaic acid, were used to develop coatings incorporating additives while avoiding cobalt-based driers. Additional agents such as leveling, wetting, and anti-skinning agents, were also included. Paints were applied to wood substrates and dried at room temperature. The resulting films were characterized by pendulum hardness, transparency, and color by colorimetry, cross-cut test, contact angle, and gloss. Thermal properties were analyzed by Differential Scanning Calorimetry (DSC), and Total Organic Carbon (TOC) content and aerobic biodegradation were also evaluated. The resulting coating films exhibited good mechanical performance, with hardness values ranging from 132 to 148 Persoz oscillations and strong adhesion to wood substrates (smooth cross-cut edges, Class 0). Significant biodegradability (70% in less than 90 days) was demonstrated under composting conditions, which was considerably higher than that of a commercial reference alkyd coating (34.7%) under the same conditions. These findings suggest that the developed bio-alkyd coatings formulated with azelaic acid and DCO-FA without cobalt-based driers represent a promising alternative to conventional phthalic acid-based alkyds. These novel coatings move closer to fully bio-based formulations and offer enhanced biodegradability, making them a more sustainable option for coating applications. Full article

Precision and non-damaging harvesting is a key direction for the development of mechanized fruit harvesting technologies. Blueberries, with their soft texture and delicate skin, present significant challenges for achieving precise and non-damaging mechanical harvesting. This paper proposes an intelligent recognition and prediction method based on machine vision. The method uses image recognition technology to extract the physical characteristics of blueberries, such as diameter and thickness, and estimates fruit hardness in real-time through a predictive model. The gripping force of the mechanical claw is dynamically adjusted to ensure non-destructive harvesting. Firstly, a chimpanzee optimization algorithm (ChOA) was used to optimize a prediction model that established a mapping relationship between fruit diameter, thickness, weight, and fruit hardness. The radial basis network optimized by the chimpanzee optimization algorithm (ChOA-RBF) model was compared with a non-optimized model, and the results showed that the ChOA-RBF prediction model has significant advantages in predicting fruit hardness. Next, an orthogonal experiment further verified the model, showing that the prediction error between the model’s values and actual values was less than 5%. Additionally, considering practical applications, a simple and efficient two-parameter method was proposed, removing the weight parameter and predicting fruit hardness using only diameter and thickness. Although the two-parameter method increases the prediction error by 0.36% compared to the three-parameter method, it reduces the number of convergence steps by 71 and shortens the computation time by one-third, significantly improving iteration speed. Finally, further crushing experiments showed that using the two-parameter method for hardness prediction through parameter extraction via visual recognition resulted in a relative error of less than 8%, with an average relative error of 3.91%. The error falls within the acceptable range for the safety factor design. This method provides a novel solution for the non-damaging mechanized harvesting of soft fruits. Full article

This study investigates the correlation between the crystallinity and mechanical properties of calendered isotactic polypropylene (iPP) foils, focusing on the influence of haul-off speed and additive type. Two groups of iPP foils produced on an industrial scale were compared: (i) foils containing 10 wt.% recycled PP at haul-off speeds of 2 and 10 m/min; and (ii) foils with different additives (neat PP, 10 wt.% recycled PP, and PP random copolymer) at a constant haul-off speed of 10 m/min. All foils exhibited a pronounced skin–core structure, with the inner surface showing higher crystallinity (up to 10%) due to slower cooling rates, as determined by Flash Differential Scanning Calorimetry (Flash DSC). Nanoindentation tests correlated these differences in crystallinity with variations in the hardness and elastic modulus across the cross-section of the foil. Higher haul-off speeds (10 m/min) resulted in increased crystallinity, a higher elastic modulus and higher hardness. Polarized optical microscopy (POM) confirmed the morphological differences and highlighted the presence of highly oriented skin layers and stratified crystalline structures. These findings emphasize the significant influence of processing conditions, such as hauling speed and the addition of recycled polypropylene or a random copolymer, on the mechanical and optical properties of iPP foils. This comprehensive approach to characterizing complex structure–property relationships is valuable for optimizing the production and performance of polypropylene-based packaging foils on an industrial scale. Full article

Background/Objectives: Research on pleasant tactile perception has primarily focused on C-tactile fibers found in hairy skin, with the forearm and face as common study sites. Recent findings of these fibers in hairless skin, such as the palms, have sparked interest in tactile stimulation on the hands. While studies have examined comfort and brain activity in passive touch, active touch remains underexplored. This study aimed to investigate differences in pleasant sensation and brain activity during active touch with stress balls of varying hardness. Methods: Forty healthy women participated. Using functional magnetic resonance imaging (fMRI), brain activity was measured as participants alternated between gripping stress balls of soft, medium, and hard hardness and resting without a ball. Participants rated hardness and comfort on a 9-point scale. Results: Soft stress balls were perceived as soft and comfortable, activating the thalamus and left insular cortex while reducing activity in the right insular cortex. Medium stress balls elicited similar perceptions and thalamic activation but with reduced right insular cortex activity. Hard stress balls caused discomfort, activating the insular cortex, thalamus, and amygdala while reducing anterior cingulate cortex activity. Conclusions: Soft stress balls may reduce aversive stimuli through perceived comfort, while hard stress balls may induce discomfort and are unlikely to alleviate stress. Full article

This study has aimed to determine the effect of pre-treatment with enzymes, ultrasound, and fruit skin perforation on the kinetics of the freeze-drying process and selected properties of the dried blueberries. The dry matter, water activity, maximal compression force, and content of flavonoids, polyphenols, and anthocyanins after the pre-treatment and drying process were measured. The enzymatic, ultrasonic, and puncture treatments reduced the hardness of the blueberries by 2.5-fold, while the content of most bioactive compounds remained similar. The structure analysis has shown that freeze-dried blueberries without pre-treatment, but subjected to sonication, were almost hollow inside due to tissue rupture. It resulted in a decrease in the hardness of dried blueberries from 324.2 N (punctured) to 107.5 N (fresh) and 184.5 N (sonicated). The content of polyphenols ranged from 173.2 to 251.0 mg GAE/g d.m. in the fruits subjected to the enzymatic treatment and perforation, respectively. The application of pre-treatment with enzymes and puncturing may be recommended for the freeze-drying of blueberries as it reduces drying time by half. Moreover, the obtained products had a similar content of most bioactive compounds to those observed for freeze-dried blueberries without pre-treatment. Full article

The wound microbiome refers to the specific community of microbes, including bacteria, fungi, and other microorganisms, that are present in and around a wound. This microbiome plays a crucial role in wound healing, as it includes both healing-promoting and pathogenic microbes. The balance between these microbes significantly influences the healing process; a balanced microbial colonization can support wound healing and prevent infections, while an overgrowth of pathogenic microbes can lead to delayed healing processes and complications. The composition of the wound microbiome can vary depending on the type of wound, cause, genetic predisposition, and (social) environment. In this scope review, the complex interactions in the wound microbiome will be highlighted and the importance of non-pathogenic microbes for wound healing will be discussed. In addition, possible therapeutic approaches to restore a healthy microbiome and prevent infections will be addressed. A deeper understanding of these dynamics could open up new perspectives for the treatment of wounds and the development of strategies to combat wound infections. Full article

High-frequency induction welding technology represents the development direction of the high-temperature corrosion protection technology for the heating surfaces of the boiler “four tubes”. However, when the high-frequency induction coil heats and remelts the coating on the tube’s outer wall, the tube’s inner wall is also heated, causing an iron oxide scale to form on the tube’s inner wall. When the remelting temperature rises and the temperature of the tube’s inner wall exceeds 580 °C, three layers of oxide films, FeO, Fe₃O₄, and Fe₂O₃ are arranged in sequence from the substrate surface of the tube’s inner wall to the outside, with a thickness ratio of approximately 1:10:100. From the XRD spectra of tube iron oxide scale, it can be seen that the oxidation of the tube. The skin is mainly composed of Fe₃O₄, with a certain amount of Fe₂O₃ and trace amounts of FeO. The iron in the diffraction peak originates from the metal matrix. However, when the remelting temperature continues to rise and the temperature of the tube’s inner wall exceeds 580 °C, the oxide film begins to thicken significantly, that is, the oxide film begins to transform into an oxide scale. Under the continuous action of high-temperature induction remelting, the reaction between iron and oxygen is accelerated, but because the oxygen ions of water slowly diffuse through two outer layers of oxide films, with a low oxygen concentration. Although the FeO film is thin, it has a loose structure and numerous lattice defects, is unstable and easy to decompose, and easily peels off from the tube’s inner wall. For a pipe wall thickness of 5 mm, if the thinning rate of the inner wall caused by detachment reaches 0.8 mm/year, it is highly likely to cause pipe burst accidents within 4–5 years. The influence of the iron oxide scale on the performance of the tube’s inner wall was evaluated by testing indexes, such as surface hardness and decarburization layer depth. Although the oxide scale reduces the surface hardness of the tube’s inner wall, the surface decarburization layer is very thin, so the effect on the mechanical properties of the tube’s substrate is limited. The technology of inhibiting the formation of the iron oxide scale in induction remelting is briefly introduced. During the high-frequency remelting process of water-cooled walls, as the tube bank moves forward relative to the high-frequency heating coil, nitrogen protection is used to suppress the formation of oxide scale, effectively eliminating the troubles caused by high-frequency induction remelting and achieving the goal of improving the service life of the tube bank. This technology of the nitrogen protection method is used to inhibit the formation of iron oxide scale, not only inhibiting the formation of the iron oxide scale on the tube inner wall and the back of the tube bundle, with remarkable experimental results and broad application prospects. Full article

Agomelatine (AGM) is an effective antidepressant with low oral bioavailability due to intensive hepatic metabolism. Transdermal administration of agomelatine may increase its bioavailability and reduce the doses necessary for therapeutic effects. However, transdermal delivery requires crossing the stratum corneum barrier. For this purpose, the use of microneedles may increase the efficiency of administration. The aim of this study was to prepare an agomelatine-loaded hydrogel suitable for coating microneedles for the transdermal drug delivery of AGM. The optimized formulations were subjected to spectroscopic and rheological characterization and mechanical tests, as well as tested for release through an artificial membrane and permeation through human skin ex vivo. Both hydrogels were found to have suitable parameters for coating microneedles using the dip-coating method, including the stability of the substance at the process temperature, shear-thinning behavior, and appropriate textural parameters such as adhesion or hardness. Additionally, two formulations were tested for potential application to the skin alone because the gels showed suitable mechanical properties for the skin application. In this case, the ethanol gel was characterized by higher skin permeability and better spreadability. The information obtained in this study will allow the preparation of coated microneedles for the transdermal administration of agomelatine. Full article