Matrix Effectors and Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 100197
Special Issue Editors
Interests: matrix biology; molecular mechanisms in breast cancer progression; proteoglycans; glycosaminoglycans; metalloproteinases
Interests: extracellular matrix; cell signaling; estrogen receptors; proteoglycans; breast cancer biomarkers; molecular targeting
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extracellular matrices (ECMs) are highly dynamic three-dimensional structural meshworks composed of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs), collagens, laminins, elastin, glycoproteins and proteinases. Matrix macromolecules are characterized by high structural complexity and heterogeneity. They form complex networks through which they dynamically communicate with cells, thus serving as critical regulators of several homeostatic and pathological processes, such as cancer. ECM molecular composition varies among the tissue of origin and it undergoes significant remodeling during cancer progression. The elucidation of the mechanistic aspects governing matrix assembly and cell–matrix interactions is of critical importance to discover matrix-mediated cancer pathobiology and novel therapeutic approaches. The aim of this Collection of Cancers is to highlight the emerging roles of effective matrix macromolecules, including matrix metalloproteinases, proteoglycans, specific types of collagens and matrix (glyco)proteins that play key roles in cancer development and aggressiveness.
Prof. Dr. Nikos KaramanosDr. Zoi Piperigkou
Collection Editors
Manuscript Submission Information
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Keywords
- extracellular matrix
- cancer pathobiology
- metalloproteinases
- matrix remodeling
- proteoglycans
- collagen
- matrix (glyco)proteins
- molecular targeting